Synthetic Strategy toward the C44–C65 Fragment of Mirabalin

A convergent and flexible stereoselective synthesis of one isomer of the C44–C65 fragment of mirabalin is described. The key steps include organocatalytic aldolization, ruthenium-catalyzed asymmetric hydrogenation, amide formation, Marshall stereoselective allenylation, and the Nozaki–Hiyama–Kishi reaction