35 research outputs found
A shelf-life study of silica- and carbon-based mesoporous materials
Mesoporous silica- and carbon-based materials, including bioactive glasses, have proven potential as components of medical devices and as drug carriers. From an application perspective, knowledge about the shelf-life stability of these materials under various conditions is vital. Here, mesoporous bioactive glasses (MBGs) synthesized by aerosol-assisted spray-drying and by a batch sol–gel method, mesoporous silicas of SBA-15 type, and mesoporous carbons CMK-1 and CMK-3 have been stored under varying conditions, e.g. at different temperature and relative humidity (RH), and in different storage vessels. The results show that the silica-based materials stored in Eppendorfs are sensitive to humidity. Spray dried MBGs decompose within 1 month at a RH >5%, whilst sol–gel MBGs are more stable up to a RH >60%. Changing the storage vessel to sealed glass flasks increases the MBGs lifetime significantly, with no degradation during 2 months of storage at a RH = 75%. SBA-15 stored in Eppendorfs are more stable compared to MBGs, and addition of F- ions added during the synthesis affects the material degradation rate. Mesoporous carbons are stable under all conditions for all time points. This systematic study clearly demonstrates the importance of storage conditions for mesoporous materials which is crucial knowledge for commercialization of these materials
A novel approach to modelling water transport and drug diffusion through the stratum corneum
<p>Abstract</p> <p>Background</p> <p>The potential of using skin as an alternative path for systemically administering active drugs has attracted considerable interest, since the creation of novel drugs capable of diffusing through the skin would provide a great step towards easily applicable -and more humane- therapeutic solutions. However, for drugs to be able to diffuse, they necessarily have to cross a permeability barrier: the <it>stratum corneum </it>(SC), the uppermost set of skin layers. The precise mechanism by which drugs penetrate the skin is generally thought to be diffusion of molecules through this set of layers following a "tortuous pathway" around corneocytes, i.e. impermeable dead cells.</p> <p>Results</p> <p>In this work, we simulate water transport and drug diffusion using a three-dimensional porous media model. Our numerical simulations show that diffusion takes place through the SC regardless of the direction and magnitude of the fluid pressure gradient, while the magnitude of the concentrations calculated are consistent with experimental studies.</p> <p>Conclusions</p> <p>Our results support the possibility for designing arbitrary drugs capable of diffusing through the skin, the time-delivery of which is solely restricted by their diffusion and solubility properties.</p
Electrosprayed mesoporous particles for improved aqueous solubility of a poorly water soluble anticancer agent: in vitro and ex vivo evaluation
open access articleEncapsulation of poorly water-soluble drugs into mesoporous materials (e.g. silica) has evolved as a favorable
strategy to improve drug solubility and bioavailability. Several techniques (e.g. spray drying, solvent evaporation,
microwave irradiation) have been utilized for the encapsulation of active pharmaceutical ingredients (APIs) into
inorganic porous matrices. In the present work, a novel chalcone (KAZ3) with anticancer properties was successfully
synthesized by Claisen-Schmidt condensation. KAZ3 was loaded into mesoporous (SBA-15 and MCM-41)
and non-porous (fumed silica, FS) materials via two techniques; electrohydrodynamic atomization (EHDA) and
solvent impregnation. The effect of both loading methods on the physicochemical properties of the particles (e.g.
size, charge, entrapment efficiency, crystallinity, dissolution and permeability) was investigated. Results indicated
that EHDA technique can load the active in a complete amorphous form within the pores of the silica particles.
In contrast, reduced crystallinity (~79%) was obtained for the solvent impregnated formulations. EHDA
engineered formulations significantly improved drug dissolution up to 30-fold, compared to the crystalline drug.
Ex vivo studies showed EHDA formulations to exhibit higher permeability across rat intestine than their solvent
impregnated counterparts. Cytocompatibility studies on Caco-2 cells demonstrated moderate toxicity at high concentrations
of the anticancer agent. The findings of the present study clearly show the immense potential of
EHDA as a loading technique for mesoporous materials to produce poorly water-soluble API carriers of high payload
at ambient conditions. Furthermore, the scale up potential in EHDA technologies indicate a viable route to
enhance drug encapsulation and dissolution rate of loaded porous inorganic materials
Determination of the spatial distribution of multiple fluid phases in porous media by ultra small angle neutron scattering
H<sub>2</sub>/D<sub>2</sub> adsorption and desorption studies on carbon molecular sieves with different pore structures
Comparing hydrogen sorption in different Pd-doped pristine and surface-modified nanoporous carbons
Three types of nanoporous carbons (a molecular sieve, an ordered mesoporous carbon and a carbon aerogel) with distinctively different porous properties were subjected to surface modification through wet oxidation and subsequent metal doping with Pd nanoparticles. The H2 sorption performance of the carbons and their doped analogues was examined at 298 K up to 20 bar. The introduction of different oxygen containing groups in the three carbons enhances the amount of sorbed hydrogen, while the rather complex mechanism of sorption seems to be positively influenced by the small size of the pores and the surface chemistry. It was shown that in all cases a synergistic effect between the metal and the oxidized carbon takes place, leading to enhanced hydrogen sorption through reversible processes, which however is not sufficient to meet the demanding targets for practical applications