Predicting in situ degradability of feed proteins in the rumen by two laboratory methods (solubility and enzymatic degradation)

International audienc

Aliments concentrés pour ruminants : prévision de la valeur azotée PDI à partir d’une méthode enzymatique standardisée

National audienc

Aliments concentrés pour ruminants : prévision de la valeur azotée PDI à partir d’une méthode enzymatique standardisée

National audienc

Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis

BACKGROUND—Liver iron deposits are frequent in viral C cirrhotic patients but their role is not well defined.
AIMS—To investigate the effect of liver iron excess on the prevalence of hepatocellular carcinoma (HCC) in patients with viral C cirrhosis.
METHODS—Hepatic iron was evaluated retrospectively using a semiquantitative method in liver biopsies of 104 viral C cirrhotic patients, 48 with HCC and 56 controls (HCC free). Corrected total iron score (0-60) was defined by the sum of three scores: hepatocytic iron score (0-36), sinusoidal iron score (0-12), and portal iron score (0-12), multiplied by 3/3, 2/3, or 1/3 according to the heterogeneous iron localisation in the nodules.
RESULTS—After adjustment for known risk factors for HCC, regression analysis showed that iron deposits (corrected total iron score >0) were more frequent in HCC patients than in controls (odds ratio 4.94; 95% confidence interval 1.59-15.32; p=0.0056). The median of corrected total iron score was significantly higher in HCC patients than in controls (odds ratio 1.092; 95% confidence interval 1.01-1.13; p=0.021). This liver iron overload was sinusoidal (odds ratio 5.2; 95% confidence interval 1.82-15.11; p=0.0022).
CONCLUSIONS—Liver iron deposition was more frequent and more important in viral C cirrhotic patients with HCC than in HCC free controls. Liver iron overload seems to contribute to the development of HCC in patients with viral C cirrhosis.


Keywords: liver; iron; viral C cirrhosis; hepatocellular carcinom

Grinding classification of pea seeds

International audienc

Influence of pea particle sizes on the gas production kinetic with rumen juice (HFT method)

International audienc

Etude de la variabilité inter-laboratoire de la dégradation de l'azote mesurée in sacco

Etude de la variabilité inter-laboratoire de la dégradation de l'azote mesurée in sacco. 22. Rencontres autour des Recherches sur les Ruminant

Etude de la variabilité inter-laboratoire de la dégradation de l'azote mesurée in sacco

Etude de la variabilité inter-laboratoire de la dégradation de l'azote mesurée in sacco. 22. Rencontres autour des Recherches sur les Ruminant

Telehealth‐delivered CBT‐I programme enhanced by acceptance and commitment therapy for insomnia and hypnotic dependence: A pilot randomized controlled trial

Cognitive behavioural therapy for insomnia is the recommended treatment for chronic insomnia. However, up to a quarter of patients dropout from cognitive behavioural therapy for insomnia programmes. Acceptance, mindfulness and values-based actions may constitute complementary therapeutic tools to cognitive behavioural therapy for insomnia. The current study sought to evaluate the efficacy of a remotely delivered programme combining the main components of cognitive behavioural therapy for insomnia (sleep restriction and stimulus control) with the third-wave cognitive behavioural therapy acceptance and commitment therapy in adults with chronic insomnia and hypnotic dependence on insomnia symptoms and quality of life. Thirty-two participants were enrolled in a pilot randomized controlled trial: half of them were assigned to a 3-month waiting list before receiving the four "acceptance and commitment therapy-enhanced cognitive behavioural therapy for insomnia" treatment sessions using videoconference. The primary outcome was sleep quality as measured by the Insomnia Severity Index and the Pittsburgh Sleep Quality Index. All participants also filled out questionnaires about quality of life, use of hypnotics, depression and anxiety, acceptance, mindfulness, thought suppression, as well as a sleep diary at baseline, post-treatment and 6-month follow-up. A large effect size was found for Insomnia Severity Index and Pittsburgh Sleep Quality Index, but also daytime improvements, with increased quality of life and acceptance at post-treatment endpoint in acceptance and commitment therapy-enhanced cognitive behavioural therapy for insomnia participants. Improvement in Insomnia Severity Index and Pittsburgh Sleep Quality Index was maintained at the 6-month follow-up. Wait-list participants increased their use of hypnotics, whereas acceptance and commitment therapy-enhanced cognitive behavioural therapy for insomnia participants evidenced reduced use of them. This pilot study suggests that web-based cognitive behavioural therapy for insomnia incorporating acceptance and commitment therapy processes may be an efficient option to treat chronic insomnia and hypnotic dependence