6 research outputs found
Carbon assessment of wind power
- Author
- Publication venue
- Energy, Geoscience, Infrastructure and Society
- Publication date
- 01/10/2015
- Field of study
The Earth is facing huge implications from Anthropogenic Global Warming and peaks
in the production of finite fossil fuels. Decision-makers have to choose strategies for
combating these dual problems whilst ensuring minimal costs to society and the
environment. Unfortunately, renewable technologies in particular have doubt associated
with their ability to reduce total life cycle greenhouse gas (GHG) emissions of
electricity due to uncertainty in estimates. This thesis analyses historic associated GHG
estimates of wind farms, the largest renewables contributor to electricity generation in
the UK, to reduce the uncertainty inherent in estimates and better understand critical
factors that influence estimation. Through harmonisation of published life cycle GHG
emissions estimates, they are reduced by 56% to between 2.9 and 37.3gCO2e/kWh.
Average values for onshore and offshore wind power are calculated as 16 and
18.2gCO2e/kWh respectively and exhibit similar characteristics in their life cycle GHG
emissions. Ormonde Offshore Wind Farm is analysed using a novel hybrid approach
and gives total baseline GHG emissions of 17.5gCO2e/kWh and is the largest wind
power installation to be analysed to date. Finally, an estimate of the effect of load
variability of wind on thermal plant in the UK system is calculated. It is shown that this
effect may reduce the net emissions saving from wind power relative to the whole UK
system’s savings when wind power is included
Mechanisms underlying a thalamocortical transformation during active tactile sensation
- Author
- A. Agmon
- A. Lerchner
- A.D. Reyes
- A.K. Kinnischtzke
- A.L. Yarbus
- B.M. Hooks
- C. Eliasmith
- C. Hull
- C. Pehlevan
- C. van Vreeswijk
- C. van Vreeswijk
- C. Yu
- C. Yu
- C.E. Chapman
- D. Feldmeyer
- D. Ferster
- D. Golomb
- D. Golomb
- D. Hansel
- D. Hansel
- D. Huber
- D. Kleinfeld
- D. Papakostopoulos
- D.B. Rubin
- D.H. Hubel
- D.H. O'Connor
- D.H. O'Connor
- D.H. O'Connor
- D.J. Pinto
- D.J. Pinto
- D.J. Simons
- D.R. Giblin
- David Golomb
- Diego Adrian Gutnisky
- E. Marder
- E. Persi
- E.E. Fanselow
- E.E. Kwegyir-Afful
- F. Zhang
- G.B. Stanley
- H. Alfonsa
- H. Markram
- H. Ozeki
- I. Bureau
- I. Hayut
- J. Kremkow
- J. Yu
- J.A. Birdwell
- J.C. Curtis
- J.D. Moore
- J.F. Poulet
- J.J. Gibson
- J.T. Porter
- J.V. Raimondo
- Jianing Yu
- K. Reinhold
- Karel Svoboda
- L. Cossell
- L. Gabernet
- L. Pammer
- L. Petreanu
- L. Petreanu
- L.R. Varshney
- M. Beierlein
- M. Brecht
- M. Brecht
- M. Fujita
- M. Hulliger
- M. Wehr
- M.E. Diamond
- M.R. DeWeese
- M.S. Fee
- M.V. Tsodyks
- Michael Ross Bale
- Minh-Son To
- N. Urbain
- N.G. Clack
- N.J. Sofroniew
- O. Shriki
- P.M. Knutsen
- Peter E. Latham
- R. Zillmer
- R.C. Reid
- R.D. Traub
- R.M. Bruno
- R.M. Bruno
- R.M. Bruno
- S. Lefort
- S. Song
- S.A. Hires
- S.B. Vincent
- S.J. Cruikshank
- S.W. Oh
- Samuel Andrew Hires
- V. Khatri
- W. Sun
- W.B. Wilent
- X. Han
- X. Jiang
- X.J. Wang
- Y. Ahmadian
- Y. Ma
- Y. Ma
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/06/2017
- Field of study
During active somatosensation, neural signals expected from movement of the sensors are suppressed in the cortex, whereas information related to touch is enhanced. This tactile suppression underlies low-noise encoding of relevant tactile features and the brain’s ability to make fine tactile discriminations. Layer (L) 4 excitatory neurons in the barrel cortex, the major target of the somatosensory thalamus (VPM), respond to touch, but have low spike rates and low sensitivity to the movement of whiskers. Most neurons in VPM respond to touch and also show an increase in spike rate with whisker movement. Therefore, signals related to self-movement are suppressed in L4. Fast-spiking (FS) interneurons in L4 show similar dynamics to VPM neurons. Stimulation of halorhodopsin in FS interneurons causes a reduction in FS neuron activity and an increase in L4 excitatory neuron activity. This decrease of activity of L4 FS neurons contradicts the "paradoxical effect" predicted in networks stabilized by inhibition and in strongly-coupled networks. To explain these observations, we constructed a model of the L4 circuit, with connectivity constrained by in vitro measurements. The model explores the various synaptic conductance strengths for which L4 FS neurons actively suppress baseline and movement-related activity in layer 4 excitatory neurons. Feedforward inhibition, in concert with recurrent intracortical circuitry, produces tactile suppression. Synaptic delays in feedforward inhibition allow transmission of temporally brief volleys of activity associated with touch. Our model provides a mechanistic explanation of a behavior-related computation implemented by the thalamocortical circuit
Prioritized sweeping: Reinforcement learning with less data and less time
- Author
- A.D. Christiansen
- A.G. Barto
- A.G. Barto
- A.G. Barto
- A.L. Samuel
- A.P. Sage
- A.W. Moore
- Andrew W. Moore
- C. Stanfill
- C.J.C.H. Watkins
- Christopher G. Atkeson
- D. Chapman
- D. Michie
- D.A. Berry
- D.E. Knuth
- D.P. Bertsekas
- G.J. Tesauro
- J. Peng
- L.J. Lin
- L.P. Kaelbling
- M. Sato
- N.J. Nilsson
- P. Dayan
- R.E. Bellman
- R.E. Korf
- R.S. Sutton
- R.S. Sutton
- R.S. Sutton
- R.S. Sutton
- S. Mahadevan
- S.B. Thrun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Children's humour: its nature and role in coping with stress
- Author
- Ahlberg Allan
- Allen S.
- Athey Christina
- Ball Samuel
- Barrs Myra
- Beckman Aileen K.
- Bell Nancy J.
- Bergson H.
- Berlyne D.E.
- Beynon J.
- Bowlby John
- Brumbaugh Florence
- Buzan Tony
- Caine Marti
- Chapman A.J.
- Chapman A.J.
- Chapman Antony J.
- Claire Gibbon
- Cleese John
- Curran F.W.
- Davies Ann P.
- Davies Ann P.
- Dawson Les
- De Bono Edward
- Donaldson Margaret
- Eastman M.
- Eysenck
- Fadiman Clifton
- Foot Hugh C
- Foot Hugh C.
- Freud Sigmund
- Gale George
- Garvey Catherine
- Gentile Lance
- Getzels Jacob W.
- Gibbon S.Y.
- Gidynsky C.G.
- Giles H.
- Ginsburg Mark B.
- Goffman Erving
- Goodacre Dr. Elizabeth
- Goodchilds J.D.
- Gordon Mike
- Grainger Sandra
- Gruner C.R.
- Hammersley M.
- Hammersley Martyn
- Hargreaves Andy
- Hargreaves David H.
- Hauck William E.
- Highet G.
- Highet G.
- Hourd Marjorie
- Hunter
- Jordan Rod
- Kaglan Jerome
- Kane Thomas R.
- Kemp Gene
- Kris E.
- Krogh Suzanne
- Kubie L.S.
- LaChance A.I.
- Levine Jacob
- Levine Jacob
- Lieberman J. Nina
- Lindgren Henry Clay
- Linfield E.
- Ludovici A.M.
- Martineau William H.
- McGhee Paul
- McGhee Paul
- McGhee Paul
- Millar Jane
- Moore Dudley
- Moskowitz G.
- Neuman L.E.
- Peach Howard
- Philp A.J.
- Piaget Jean
- Pollard A.
- Potter Stephen
- Prefrost F.J.
- Rosenwald G.C.
- Salway Lance
- Sarason S.B.
- Schultz Thomas
- Schultz Thomas
- Selkirk Keith
- Stebbins Robert A.
- Thompson Brenda
- Waterman Jill Marcia
- Wilkinson W.J.
- Winnicott D. W.
- Wolfenstein Martha
- Woods Peter
- Woods Peter
- Woods Peter
- Woods Peter
- Zigler E.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Search for gravitational waves from Scorpius X-1 with a hidden Markov model in O3 LIGO data
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley K.
- Adhikari N.
- Adhikari R.X.
- Adkins V.K.
- Adya V.B.
- Affeldt C.
- Agarwal D.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Aiello Lorenzo
- Ain A.
- Ajith P.
- Akutsu T.
- Albanesi S.
- Alfaidi R.A.
- Allocca A.
- Altin P.A.
- Amato A.
- Anand C.
- Anand S.
- Ananyeva A.
- Anderson S.B.
- Anderson W.G.
- Ando M.
- Andrade T.
- Andres N.
- Andri? T.
- Andrés-Carcasona M.
- Angelova S.V.
- Ansoldi S.
- Antelis J.M.
- Antier S.
- Apostolatos T.
- Appavuravther E.Z.
- Appert S.
- Apple S.K.
- Arai K.
- Araya A.
- Araya M.C.
- Areeda J.S.
- Arellano F.E.Peña
- Aritomi N.
- Arnaud N.
- Arogeti M.
- Aronson S.M.
- Arène M.
- Asada H.
- Asali Y.
- Ashton G.
- Aso Y.
- Assiduo M.
- Aston S.M.
- Astone P.
- Aubin F.
- AultONeal K.
- Austin C.
- Babak S.
- Badaracco F.
- Bader M.K.M.
- Badger C.
- Bae S.
- Bae Y.
- Baer A.M.
- Bagnasco S.
- Bai Y.
- Baird J.
- Bajpai R.
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S.W.
- Balsamo A.
- Baltus G.
- Banagiri S.
- Banerjee B.
- Bankar D.
- Barayoga J.C.
- Barbieri C.
- Barish B.C.
- Barker D.
- Barneo P.
- Barone F.
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- Barsotti L.
- Barsuglia M.
- Barta D.
- Bartlett J.
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- Becher B.R.
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- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 21/09/2022
- Field of study
Results are presented for a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to allow for spin wandering. This search improves on previous HMM-based searches of Laser Interferometer Gravitational-Wave Observatory data by including the orbital period in the search template grid, and by analyzing data from the latest (third) observing run. In the frequency range searched, from 60 to 500 Hz, we find no evidence of gravitational radiation. This is the most sensitive search for Scorpius X-1 using a HMM to date. For the most sensitive subband, starting at 256.06 Hz, we report an upper limit on gravitational wave strain (at 95% confidence) of
h
95
%
0
=
6.16
×
10
−
26
, assuming the orbital inclination angle takes its electromagnetically restricted value
ι
=
4
4
°
. The upper limits on gravitational wave strain reported here are on average a factor of
∼
3
lower than in the second observing run HMM search. This is the first Scorpius X-1 HMM search with upper limits that reach below the indirect torque-balance limit for certain subbands, assuming
ι
=
4
4
°
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
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- Zlatopolsky Menachem
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease