Study on dynamic characteristics of silt solidified soil caused by train operation

With the rapid development of railway construction, many railway projects often cross the soft ground. The initial water content of the silt is too high to be directly applied to the engineering practice. In order to improve the engineering property of the silt, the corresponding precipitation treatment measures should be taken according to the different initial water content of the silt to ensure the safety of the project. This article relying on Shilong railway freight yard container project that contain silt soil to conduct in situ curing technology research, the vibration response characteristics of the stabilized soil was studied before and after curing. The results showed that silt solidified soil has a significant attenuation effect on vibration energy. Increasing the proportion of curing agent can enhance the vibration isolation effect of silt solidified soil

An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis

Publisher Copyright: © 2022, The Author(s).Lipid remodeling is crucial for malignant cell transformation and tumorigenesis, but the precise molecular processes involved and direct evidences for these in vivo remain elusive. Here, we report that oxysterol-binding protein (OSBP)-related protein 4 L (ORP4L) is expressed in adult T-cell leukemia (ATL) cells but not normal T-cells. In ORP4L knock-in T-cells, ORP4L dimerizes with OSBP to control the shuttling of OSBP between the Golgi apparatus and the plasma membrane (PM) as an exchanger of phosphatidylinositol 4-phosphate [PI(4)P]/cholesterol. The PI(4)P arriving at the PM via this transport machinery replenishes phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2] and phosphatidylinositol (3,4,5) trisphosphate [PI(3,4,5)P-3] biosynthesis, thus contributing to PI3K/AKT hyperactivation and T-cell deterioration in vitro and in vivo. Disruption of ORP4L and OSBP dimerization disables PI(4)P transport and T-cell leukemogenesis. In summary, we identify a non-vesicular lipid transport machinery between Golgi and PM maintaining the oncogenic signaling competence initiating T-cell deterioration and leukemogenesis. The oxysterol-binding protein-related protein 4 (ORP4L) is expressed in T-cell acute lymphoblastic leukemia and is required for leukemogenesis. Here the authors show that ORP4L orchestrates the transport of the phospholipid PI(4)P from Golgi to the plasma membrane, contributing to PI3K/AKT hyperactivation and T-cell leukemogenesis.Peer reviewe

ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLC beta 3 Catalysis : Targeting It Eradicates Leukemia Stem Cells

Leukemia stem cells (LSCs) are a rare subpopulation of abnormal hematopoietic stem cells (HSCs) that propagates leukemia and are responsible for the high frequency of relapse in therapies. Detailed insights into LSCs' survival will facilitate the identification of targets for therapeutic approaches. Here, we develop an inhibitor, LYZ-81, which targets ORP4L with high affinity and specificity and selectively eradicates LCSs in vitro and in vivo. ORP4L is expressed in LSCs but not in normal HSCs and is essential for LSC bioenergetics and survival. It extracts PIP2 from the plasma membrane and presents it to PLC beta 3, enabling IP3 generation and subsequentCa(2+)-dependent bioenergetics. LYZ-81 binds ORP4L competitively with PIP2 and blocks PIP2 hydrolysis, resulting in defective Ca2+ signaling. The results provide evidence that LSCs can be eradicated through the inhibition of ORP4L by LYZ-81, which may serve as a starting point of drug development for the elimination of LSCs to eventually cure leukemia.Peer reviewe

Research progress of annular flume technology

The background and principle of the annular flume technology were introduced. A complete literature review of the research progress by using the annular flume in China and other countries was presented including annular flume numerical simulation, experiments on the scene etc. On the basis of the existing progress, the potential application prospects of annular flume technology in the study of cohesive sediment characteristics are summarized briefly. There are lots of rivers in China with many different types. A huge amount sediments was carried into the sea every year, for example, the actual sediment carried into the sea from Yangtze river has the maximum amount of 0.678 billion tons,of whichthe cohesive fine sediments accounts for the majority, part of which settles down in the estuary area[1]. The research on the deposition, erosion and some other movement principles of the cohesive fine sediment is the important part of the study of fine sediment and pollutant transport and diffusion. Fine sediment movement not only subjects to the control of flow condition, bioturbation, but also depends largely on the sediment itself geometric, physical and chemical properties(such as particle size, shape, pore water, mineral components, etc.), these result a big difference of motion compared to non-viscous coarse sediment. Partheniades and his partner designed the annular flume. After that, annular flume is widely used in the study of sediment erosion, deposition, transport, and other aspects by researchers, and the researchers have made a series of progress, bring an important impact on estuary development and evolution, channel regulation and coastal engineering construction

Weakly Polarized Organic Cation-Modified Hydrated Vanadium Oxides for High-Energy Efficiency Aqueous Zinc-Ion Batteries

Highlights A vanadium oxide (TMPA-VOH) is synthesized with trimethylphenylammonium cations chemically pre-inserted into hydrated vanadium oxide. The pre-intercalation of weakly polarized organic cations strategically utilizes both ionic and molecular pre-intercalation effects. TMPA-VOH, with modified crystal structure and morphology, increased V4+ content, and weakened electrostatic interactions between Zn2+ and the V-O lattice, demonstrates enhanced voltage, storage capacity, structural stability, and reaction kinetics

Postprocessing Study for the Controllable Structures of Ceramic Green Parts Realized by a Flexible Binder Jetting Printing (BJP) Solution

For indirect ceramic additive manufacturing (AM), green parts’ initial densities are low, limiting the postprocessing strengthening under atmospheric pressure. This study employed binder jetting printing (BJP) based on the polycondensation curing of urea-formaldehyde resin to produce series of Al2O3 green specimens with controllable structures. Further, an integrated postprocessing procedure, including the sequential stages of presintering, ceramic slurry infiltration, and final sintering, was conducted on these green specimens with designed structural characteristics for verifying strengthening mechanism. Using a self-developed BJP machine system and the related material which are flexible in process, this study printed green specimens with strong bonding (flexural strength above 6.84 MPa), additionally can regulate their initial densities within the wide range between 21.7%∼43.9%. Infiltrated with ceramic slurry, low-density green specimens were significantly strengthened via final sintering, realizing final densities, flexural strength, and compressive strength of 73.2%, 43.15 MPa, and 331.17 MPa, respectively. In comparison, high-density specimens performing poor infiltration obtained limited density increment after final sintering, but better mechanical properties and surface strengthening were realized, exhibiting final densities, flexural strength, comprehensive strength, surface roughness Ra, and Vickers hardness of 70.1%, 63.22 MPa, 450.18 MPa, 9.73 μm, and 4.58 GPa, respectively. In summary, this study is helpful to provide the technical reference for custom AM ceramic green parts and the postprocessing optimization

Association between inflammation markers and all-cause mortality in critical ill patients with atrial fibrillation: Analysis of the Multi-Parameter Intelligent Monitoring in Intensive Care (MIMIC-IV) database

Background: Inflammation is related to cardiovascular disease. Among the many inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) were considered as novel predictors for atherosclerosis outcomes. We aimed to investigate the impact of these inflammatory markers on the prognosis of patients with atrial fibrillation (AF). Methods: We obtained data on AF patients from the Medical Information Mart for Intensive Care (MIMIC)-IV database. These patients were classified into two groups based on their survival status within 30 days. Then, they were divided into three groups based on the tertile of baseline NLR, PLR, and SII, respectively. We comprehensively explored the relationship between those inflammatory indicators and all-cause mortality in patients with AF by Kaplan-Meier analysis, multivariate Cox regression analysis, receiver operating characteristic (ROC) analyses, restricted cubic spline regression (RCS), and subgroup analysis. Results: A total of 4562 patients with AF were included. Statistically significant differences were found between survivor and non-survivor groups for NLR, PLR and SII. Patients in the high tertile of the NLR had a higher mortality rate than those in the low and intermediate tertiles, as did patients in the PLR and the SII. NLR, PLR and SII were independently associated with increased risk of all-cause mortality. RCS showed that the 30-day and 365-day risk of death were linearly associated with increases in NLR, PLR, and SII, respectively. Conclusion: NLR, PLR, and SII have the potential to be used as indicators for stratifying the risk of mortality in critically ill patients with AF

Research on Performance Deterioration of Internally Cured Pavement Concrete under the Coupling Effect of Salt Freeze–Thaw

This paper aims at solving the material durability problem caused by spraying deicing salt on pavement concrete in the northern winter. Super absorbent polymer (SAP) was adopted as an internal curing agent to enhance the durability of pavement concrete. Curing parameters including particle size and dosage of SAP and curing condition were optimized based on mortar tests by means of the grey target decision method. The deterioration rule of durability and mechanical properties of pavement concrete internally cured by different SAP dosages after salt freeze–thaw cycles were explored through rapid freeze–thaw test. Combined with the characteristics of pore structure, hydration and microstructure, the influence mechanism of SAP on the salt freeze–thaw resistance of pavement concrete was revealed. The experimental results showed that: (i) The reduction in mass loss rate and relative dynamic modulus was significantly improved by SAP internal curing with moderate dosage; (ii) The more freeze–thaw cycles the specimen underwent, the greater the increase in strength; (iii) After 75 cycles, the chloride ion erosion depth could be decreased by approximately 23.18%. Moreover, the addition of SAP could refine the pore size, inhibit the generation of shrinkage microcracks, and promote the degree of cement hydration in the late stage, which improved the internal density of the cement concrete structure. Therefore, the deterioration of pavement under the coupling effect of salt freeze–thaw was reduced