1 research outputs found
Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C–H Activation
An
RhÂ(III)-catalyzed C–H activation of pyrazolones with
1,6-enynes was investigated. The regioselectivity of the C–H
activation/alkyne insertion is readily solved by using symmetric enyne
coupling partners, and a C–H activation-triggered cascade reaction
is realized, which involves alkyne insertion, tautomerization, and
double cyclization to offer a class of structurally complex polycyclic
architectures. This cascade reaction tolerates a broad substrate scope
in high regioselectivity and stereospecificity and furnishes three
new chemical bonds and four chiral centers in a single operation.
Various derivatizations of the polycyclic scaffolds are conducted,
providing products with ample space for further functional transformations