Meta-analysis of Incidence of Brain Cancer Among Aircrew

Introduction: Previous studies on Brain and other Nervous System Cancers (BNSC) and aircrew have shown inconsistent results, possibly due to their relatively small sample sizes; therefore, the current study aimed to increase the precision of risk estimates.Methods: Systematic searches of PubMed and Embase for pertinent studies up to August 2016 were performed and supplemented by manual reviews of bibliographies. The pooled standard incidence ratio (SIR) and corresponding 95% CIs were estimated with random effects models.Results: Among the 903 studies retrieved, 7 studies (5 cohort studies and 2 pooled analyses) were included in the current meta-analysis. The pooled SIR (95% CI) of BNSC incidence in aircrew was 1.01 (0.77, 1.31) with no significant heterogeneity (I2 = 36.1%, P = .199). The null association persisted when the analysis was stratified by geographic area (Europe or America), publication year (before or after 2001), air population (pilots or cabin crew), cancer site (brain, nervous system, or brain/nervous system), and gender (male or female).Conclusion: The current evidence is not sufficient to support a significant positive association between aircrew employment and BNSC risk. However, the interpretation and extrapolation of this meta-analysis are restricted by the possible impact exerted by health worker effect and potential clinical heterogeneity. More studies based on other populations, including Asian aircrews, are warranted

The impact of SARS-Cov-2 infection on the periocular injection pain and hypersensitive reaction to botulinum toxin type A: results from clinical questionnaires

BackgroundThe COVID-19 pandemic has brought about significant changes in the medical field, yet the use of botulinum toxin type A has remained uninterrupted. Plastic surgeons must carefully consider the timing of administering botulinum toxin type A to patients who have recovered from COVID-19.MethodsA questionnaire survey was conducted among patients who had contracted and recovered from SARS-CoV-2 within a month. The survey aimed to investigate various indicators in patients who had received botulinum toxin A injections at the same site before and after their infection, including pain scores and allergic reactions and the occurrence of complications.ResultsThe pain scores of patients who contracted SARS-CoV-2 infection between 14-21 days post-infection exhibited significant variation from previous injections. However, patients who contracted the infection between 22-28 days post-infection did not exhibit significant variation from previous injections. Furthermore, the incidence of allergic reactions and complications following botulinum toxin injection within one month after contracting the infection did not significantly differ from that observed prior to infection.ConclusionAdministering botulinum toxin type A three weeks after COVID-19 recovery is a justifiable and comparatively secure approach

Atomic layer deposition applications 12

The objective of the current study was to explore the role of ABCB1 and CYP3A5 genetic polymorphisms in predicting the bioavailability of tacrolimus and the risk for post-transplant diabetes. Artificial neural network (ANN) and logistic regression (LR) models were used to predict the bioavailability of tacrolimus and risk for post-transplant diabetes, respectively. The five-fold cross-validation of ANN model showed good correlation with the experimental data of bioavailability (r2 = 0.93-0.96). Younger age, male gender, optimal body mass index were shown to exhibit lower bioavailability of tacrolimus. ABCB1 1236 C>T and 2677G>T/A showed inverse association while CYP3A5*3 showed a positive association with the bioavailability of tacrolimus. Gender bias was observed in the association with ABCB1 3435 C>T polymorphism. CYP3A5*3 was shown to interact synergistically in increasing the bioavailability in combination with ABCB1 1236 TT or 2677GG genotypes. LR model showed an independent association of ABCB1 2677 G>T/A with post transplant diabetes (OR: 4.83, 95% CI: 1.22-19.03). Multifactor dimensionality reduction analysis (MDR) revealed that synergistic interactions between CYP3A5*3 and ABCB1 2677 G>T/A as the determinants of risk for post-transplant diabetes. To conclude, the ANN and MDR models explore both individual and synergistic effects of variables in modulating the bioavailability of tacrolimus and risk for post-transplant diabetes

Magnetic resonance imaging based deep-learning model: a rapid, high-performance, automated tool for testicular volume measurements

BackgroundTesticular volume (TV) is an essential parameter for monitoring testicular functions and pathologies. Nevertheless, current measurement tools, including orchidometers and ultrasonography, encounter challenges in obtaining accurate and personalized TV measurements.PurposeBased on magnetic resonance imaging (MRI), this study aimed to establish a deep learning model and evaluate its efficacy in segmenting the testes and measuring TV.Materials and methodsThe study cohort consisted of retrospectively collected patient data (N = 200) and a prospectively collected dataset comprising 10 healthy volunteers. The retrospective dataset was divided into training and independent validation sets, with an 8:2 random distribution. Each of the 10 healthy volunteers underwent 5 scans (forming the testing dataset) to evaluate the measurement reproducibility. A ResUNet algorithm was applied to segment the testes. Volume of each testis was calculated by multiplying the voxel volume by the number of voxels. Manually determined masks by experts were used as ground truth to assess the performance of the deep learning model.ResultsThe deep learning model achieved a mean Dice score of 0.926 ± 0.034 (0.921 ± 0.026 for the left testis and 0.926 ± 0.034 for the right testis) in the validation cohort and a mean Dice score of 0.922 ± 0.02 (0.931 ± 0.019 for the left testis and 0.932 ± 0.022 for the right testis) in the testing cohort. There was strong correlation between the manual and automated TV (R2 ranging from 0.974 to 0.987 in the validation cohort; R2 ranging from 0.936 to 0.973 in the testing cohort). The volume differences between the manual and automated measurements were 0.838 ± 0.991 (0.209 ± 0.665 for LTV and 0.630 ± 0.728 for RTV) in the validation cohort and 0.815 ± 0.824 (0.303 ± 0.664 for LTV and 0.511 ± 0.444 for RTV) in the testing cohort. Additionally, the deep-learning model exhibited excellent reproducibility (intraclass correlation >0.9) in determining TV.ConclusionThe MRI-based deep learning model is an accurate and reliable tool for measuring TV

Nano-Engineering of Densely Packed Electrochemical Energy Storage Architectures by Atomic Layer Deposition

Nanostructures are highly attractive for future electrical energy storage devices because they enable large surface area and short ion transport time through thin electrode layers for high power devices. Significant enhancement in power density of batteries has been achieved by nano-engineered structures, particularly anode and cathode nanostructures spatially separated far apart by a porous membrane and/or a defined electrolyte region. A self-aligned nanostructured battery fully confined within a single nanopore presents a powerful platform to determine the rate performance and cyclability limits of nanostructured storage devices. Atomic layer deposition (ALD) has enabled us to create and evaluate such structures, comprised of nanotubular electrodes and electrolyte confined within anodic aluminum oxide (AAO) nanopores. The V2O5- V2O5 symmetric nanopore battery displays exceptional power-energy performance and cyclability when tested as a massively parallel device (~2billion/cm2), each with ~1m3 volume (~1fL). Cycled between 0.2V and 1.8V, this full cell has capacity retention of 95% at 5C rate and 46% at 150C, with more than 1000 charge/discharge cycles. These results demonstrate the promise of ultrasmall, self-aligned/regular, densely packed nanobattery structures as a testbed to study ionics and electrodics at the nanoscale with various geometrical modifications and as a building block for high performance energy storage systems[1, 2]. Further increase of full cell output potential is also demonstrated in asymmetric full cell configurations with various low voltage anode materials. The asymmetric full cell nanopore batteries, comprised of V2O5 as cathode and prelithiated SnO2 or anatase phase TiO2 as anode, with integrated nanotubular metal current collectors underneath each nanotubular storage electrode, also enabled by ALD. By controlling the amount of lithium ion prelithiated into SnO2 anode, we can tune full cell output voltage in the range of 0.3V and 3V. This asymmetric nanopore battery array displays exceptional rate performance and cyclability. When cycled between 1V and 3V, it has capacity retention of approximately 73% at 200C rate compared to 1C, with only 2% capacity loss after more than 500 charge/discharge cycles. With increased full cell output potential, the asymmetric V2O5-SnO2 nanopore battery shows significantly improved energy and power density. This configuration presents a more realistic test - through its asymmetric (vs symmetric) configuration – of performance and cyclability in nanoconfined environment. This dissertation covers (1) Ultra small electrochemical storage platform design and fabrication, (2) Electron and ion transport in nanostructured electrodes inside a half cell configuration, (3) Ion transport between anode and cathode in confined nanochannels in symmetric full cells, (4) Scale up energy and power density with geometry optimization and low voltage anode materials in asymmetric full cell configurations. As a supplement, selective growth of ALD to improve graphene conductance will also be discussed[3]. References: 1. Liu, C., et al., (Invited) A Rational Design for Batteries at Nanoscale by Atomic Layer Deposition. ECS Transactions, 2015. 69(7): p. 23-30. 2. Liu, C.Y., et al., An all-in-one nanopore battery array. Nature Nanotechnology, 2014. 9(12): p. 1031-1039. 3. Liu, C., et al., Improving Graphene Conductivity through Selective Atomic Layer Deposition. ECS Transactions, 2015. 69(7): p. 133-138

Individual investor attention and stock market performance——Based on big data measurement

Investor attention is a Sizerce resource, and only the information that investors pay attention to can be reflected in the stock market through transactions. Considering about the development of big data, this paper uses data mining and crawling software to crawl the daily indicators of individual investor attention in 2019. Through a fixed-effect panel data regression model, this paper examines the relationship of personal attention and stock market performance indicators over the same period. This paper found that individual investors’ attention can have a significant positive correlation with the liquidity and profitability indicators of stock market performance

The Impact of Renewable Energy Technology Innovation on Industrial Green Transformation and Upgrading: Beggar Thy Neighbor or Benefiting Thy Neighbor

Renewable energy technology innovation (RETI) is a crucial way to improve energy poverty and combat climate change. However, few studies have examined the impact of RETI on industrial green transformation and upgrading (IGTU) from the perspective of spatial spillover and its regional boundary. Based on the theory of green growth and sustainable development, this paper expands the connotation boundary of IGTU and measures the IGTU levels of 30 provinces in China from 2006 to 2020 using an improved entropy weight method. Kernel density estimation and Moran’s I index are adopted to portray temporal and spatial patterns, the spatial Durbin model is employed to examine the influencing mechanism and spatial spillover effects of RETI on IGTU and its regional boundaries, and the differential impact of its spatial effects on time, region, resource endowment, and environmental regulation are explored further. The results show that (1) RETI and IGTU in China are steadily increasing, indicating a decreasing spatial differentiation pattern of “east–west”; (2) RETI significantly promotes local IGTU but inhibits neighboring IGTU, forming a “beggar-thy-neighbor” situation; (3) the spatial spillover effect of RETI on IGTU has significant regional boundaries—the spatial spillover effect significantly negative and persists up to 800 km, but it is significantly positive from 800 to 1400 km and shows a trend of increasing and then decreasing; and (4) the promoting effect of RETI on IGTU gradually increases over time, presenting spatial differences of promotion in the east and inhibition in the west. Furthermore, RETI has a more substantial promoting effect on IGTU in non-resource-based regions and strong environmental regulation regions. The findings for China provide concrete evidence for formulating targeted policies and seeking a path for IGTU for other developing countries

The Impact of Renewable Energy Technology Innovation on Industrial Green Transformation and Upgrading: Beggar Thy Neighbor or Benefiting Thy Neighbor

Renewable energy technology innovation (RETI) is a crucial way to improve energy poverty and combat climate change. However, few studies have examined the impact of RETI on industrial green transformation and upgrading (IGTU) from the perspective of spatial spillover and its regional boundary. Based on the theory of green growth and sustainable development, this paper expands the connotation boundary of IGTU and measures the IGTU levels of 30 provinces in China from 2006 to 2020 using an improved entropy weight method. Kernel density estimation and Moran’s I index are adopted to portray temporal and spatial patterns, the spatial Durbin model is employed to examine the influencing mechanism and spatial spillover effects of RETI on IGTU and its regional boundaries, and the differential impact of its spatial effects on time, region, resource endowment, and environmental regulation are explored further. The results show that (1) RETI and IGTU in China are steadily increasing, indicating a decreasing spatial differentiation pattern of “east–west”; (2) RETI significantly promotes local IGTU but inhibits neighboring IGTU, forming a “beggar-thy-neighbor” situation; (3) the spatial spillover effect of RETI on IGTU has significant regional boundaries—the spatial spillover effect significantly negative and persists up to 800 km, but it is significantly positive from 800 to 1400 km and shows a trend of increasing and then decreasing; and (4) the promoting effect of RETI on IGTU gradually increases over time, presenting spatial differences of promotion in the east and inhibition in the west. Furthermore, RETI has a more substantial promoting effect on IGTU in non-resource-based regions and strong environmental regulation regions. The findings for China provide concrete evidence for formulating targeted policies and seeking a path for IGTU for other developing countries

Air pressure and comfort study of the high-speed train passing through the subway station

Subway is an increasingly important means of transportation, the influence of the piston effect on the train has attracted extensive attention of researchers. Nowadays, the train speed is increasingly faster, the piston effect caused by the high-speed train is increased accordingly and the pressure fluctuation in tunnel is more complex. In this study, the numerical simulation method is used to study the pressure fluctuation inside and outside the train when the train passes through the tunnel and station. The influence of train speed, mode of the train passing through the station and number of airshafts on the train pressure is analyzed. It is found that both the external and internal pressures of the train increase significantly with the increases of the train speed, and the head carriage bears the most pressure. As the mode of the train passes the station changed, there is a slight variation of train pressure. The airshafts can relieve the pressure inside the train. Finally, passenger comfort under different operating conditions is studied. Different air tightness indexes of the train are compared and analyzed. This study will contribute to the improvement of subway comfort and provide references for the design and operation of the train