Les phases de temporisation en implantologie (données actuelles)

LYON1-BU Santé Odontologie (693882213) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Limited Accessibility to Surface Area Generated by Thermal Pretreatment of Electrodes Reduces Its Impact on Redox Flow Battery Performance

Thermal oxidation of carbon electrodes is a common approach to improving flow battery performance. Here, we investigate how thermal pretreatment increases electrode surface area and the effect this added surface area has on electrode performance. Specifically, we rigorously analyze the surface area of Freudenberg H23 carbon paper electrodes, a binder-free model material, by systematically varying pretreatment temperature (400, 450, and 500 °C) and time (0 to 24 h) and evaluating changes in the physical, chemical, and electrochemical properties of the electrodes. We compare physical surface area, measured by a combination of gas adsorption techniques, to surface area measured via electrochemical double layer capacitance. We find good agreement between the two at shorter treatment times (0-3 h); however, at longer treatment times (6-24 h), the surface area measured electrochemically is an underestimate of the physical surface area. Further, we use gas adsorption to measure a pore size distribution and find that the majority of pores are in the micropore range (< 2 nm), and ca. 60% of the added surface area are in the sub-nanometer (< 1 nm) pore size range. We postulate that the solvated radii and imperfect wetting of electrochemical species may hinder active species transport into these recessed regions, explaining the discrepancy between electrochemical and physical surface area. These results are supported with in situ flow cell testing, where single-electrolyte polarization measurements show little improvement with increasing surface area. Further, using a simple convection-reaction model to simulate electrode overpotential as a function of surface area, we find that increasing surface area improves the performance to a point, but the mass transport to and the catalytic activity of the reaction sites offer greater comparative impact. Ultimately, this work aims to inform the design of electrodes that offer maximal accessible surface area to redox species

Managed care's clinical and economic impact on patients with type II diabetes in France: a controlled population-based study.

International audiencePURPOSE: The purpose of this paper is to assess the impact of five type II diabetes managed care programmes (MCPs) in clinical and economic terms at the community level in which these programmes function in the Provence-Alpes-Côte d'Azur region of France. DESIGN/METHODOLOGY/APPROACH: A prospective, controlled, before-and-after study (2001-2004) compared diabetic patients who lived in departments (localities) with (the experimental group) and without a MCP (the control group). Quality of care was estimated by the conformity of health care professionals' practices when following-up type II diabetes. Costs are compared from a health service perspective. FINDINGS: The study finds that of 626 patients enrolled, 529 lived in departments with an MCP and 97 patients in departments without. Type II diabetes follow-up globally improved between the two study periods (2001 and 2004), but the study did not show significant differences between the two groups, except for the proportion of creatinine and ophthalmologic examinations, which were higher for the control group. The study did not find significant differences in the increase of costs between the two groups from 2001 to 2004. RESEARCH LIMITATIONS/IMPLICATIONS: This type of study could constitute a methodological model to assess the MCPs population impact. PRACTICAL IMPLICATIONS: MCPs probably did not reach a critical size in terms of patient recruitment and healthcare professional adhesion to have a significant impact at a population level. ORIGINALITY/VALUE: The study highlights a number of points to consider for future MCPs in France

Managed care's clinical and economic impact on patients with type II diabetes in France: a controlled population-based study.

International audiencePURPOSE: The purpose of this paper is to assess the impact of five type II diabetes managed care programmes (MCPs) in clinical and economic terms at the community level in which these programmes function in the Provence-Alpes-Côte d'Azur region of France. DESIGN/METHODOLOGY/APPROACH: A prospective, controlled, before-and-after study (2001-2004) compared diabetic patients who lived in departments (localities) with (the experimental group) and without a MCP (the control group). Quality of care was estimated by the conformity of health care professionals' practices when following-up type II diabetes. Costs are compared from a health service perspective. FINDINGS: The study finds that of 626 patients enrolled, 529 lived in departments with an MCP and 97 patients in departments without. Type II diabetes follow-up globally improved between the two study periods (2001 and 2004), but the study did not show significant differences between the two groups, except for the proportion of creatinine and ophthalmologic examinations, which were higher for the control group. The study did not find significant differences in the increase of costs between the two groups from 2001 to 2004. RESEARCH LIMITATIONS/IMPLICATIONS: This type of study could constitute a methodological model to assess the MCPs population impact. PRACTICAL IMPLICATIONS: MCPs probably did not reach a critical size in terms of patient recruitment and healthcare professional adhesion to have a significant impact at a population level. ORIGINALITY/VALUE: The study highlights a number of points to consider for future MCPs in France

Détournement d'usage du trihexyphénidyle (Artane

De récentes observations suggèrent l'existence d'un détournement du trihexyphénidyle pour ses effets hallucinatoires et désinhibants. Afin de déterminer l'importance de cette pratique et les caractéristiques des consommateurs, une étude a été réalisée à partir des bases de données de l'Assurance Maladie de Provence-Alpes-Côte-d'Azur (PACA) et Corse. Les assurés ayant eu un remboursement de trihexyphénidyle entre le 1er janvier 2001 et le 15 février 2001 ont été inclus, soit 3028 sujets. Leurs délivrances ont été suivies pendant 9 mois. Un sous-groupe de 2,1 % de sujets ayant un comportement déviant a été identifié par analyse factorielle et comparé au sous-groupe non déviant. Les sujets déviants sont plus jeunes, à prédominance masculine. La posologie de trihexyphénidyle est élevée (28 mg/j versus 7 mg/j), avec une proportion plus importante de benzodiazépines et de buprénorphine haut dosage associées. Le nombre de délivrances est plus élevé (23,0 versus 7,7), comme le nombre de médecins (4,9 versus 1,5) et de pharmacies (5,0 versus 1,3). Cette étude confirme le potentiel d'abus et de dépendance du trihexyphénidyle et la nécessité de renforcer sa surveillance

ALZHEIMER RISK FACTOR PICALM IS INVOLVED IN TAU PATHOLOGY IN ALZHEIMER AND OTHER TAUOPATHIES

info:eu-repo/semantics/publishe

Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas

Pola NetworkInternational audienceThe integrated diagnosis of anaplastic oligodendroglioma, IDH mutant and 1p/19q co-deleted, grade III (O3id) is a histomolecular entity that WHO 2016 classification distinguished from other diffuse gliomas by specific molecular alterations. In contrast, its cell portrait is less well known. The present study is focused on intertumor and intratumor, cell lineage-oriented, heterogeneity in O3id. Based on pathological, transcriptomic and immunophenotypic studies, a novel subgroup of newly diagnosed O3id overexpressing neuronal intermediate progenitor (NIP) genes was identified. This NIP overexpression pattern in O3id is associated with: (i) morphological and immunohistochemical similarities with embryonic subventricular zone, (ii) proliferating tumor cell subpopulation with NIP features including expression of INSM1 and no expression of SOX9, (iii) mutations in critical genes involved in NIP biology and, (iv) increased tumor necrosis. Interestingly, NIP tumor cell subpopulation increases in O3id recurrence compared with paired newly diagnosed tumors. Our results, validated in an independent cohort, emphasize intertumor and intratumor heterogeneity in O3id and identified a tumor cell subpopulation exhibiting NIP characteristics that is potentially critical in oncogenesis of O3id. A better understanding of spatial and temporal intratumor cell heterogeneity in O3id will open new therapeutic avenues overcoming resistance to current antitumor treatments