Elucidation of molecular basis of osteolytic bone lesions in advanced multiple myeloma

Osteolytic bone lesion is a major cause of decreased quality of life and poor prognosis in patients with multiple myeloma (MM), but molecular pathogenesis of the osteolytic process in MM remains elusive. Fms-like tyrosine kinase 3 ligand (FLT3L) was reported to be elevated in bone marrow and blood of patients with advanced MM who often show osteolysis. Here, we investigated a functional link of FLT3L to osteolytic process in MM. We recruited 86, 306 and 52 patients with MM, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), respectively. FLT3L levels of patients with hematologic malignancies were measured in bone marrow-derived plasma and found to be significantly elevated in MM than in AML or ALL that rarely show osteolysis. FLT3L levels were further elevated in MM patients with bone lesion compared with patients without bone lesion. In vitro cell-based assays showed that the administration of FLT3L to HEK293T, HeLa and U2OS cells led to an increase in the DKK1 transcript level through STAT3 phosphorylation at tyrosine 705. WNT reporter assay showed that FLT3L treatment reduced WNT signaling, and nuclear translocation of β-catenin. These results collectively show that FLT3L-STAT3-DKK1 pathway inhibits WNT signaling-mediated bone formation in MM, which can cause osteolytic bone lesion. Finally, transcriptomic profiles revealed that FLT3L and DKK1 were predominantly elevated in the hyperdiploidy subtype of MM. Taken together, FLT3L can serve as a promising biomarker for predicting osteolytic bone lesion and also a potential therapeutic target to prohibit the progression of osteolytic process in MM with hyperdiploidy

Joint Rate and Voltage Adaptation to Save Energy of Software Radios in Underutilized WLAN

This paper proposes an energy-saving bit-rate adaptation algorithm for Software-defined Radio (SDR)-based wireless systems, called Joint Rate and Voltage Fallback (JRF). It exploits the unused network time in underutilized networks by using a lower bit-rate than what an underlying rate adaptation algorithm such as Auto-rate Fallback (ARF) or Robust Rate Adaptation Algorithm (RRAA) dictates. While slow or low bitrate communication potentially consumes more energy due to its extended communication time, it saves energy in SDR due to the possibility of reducing the speed and the voltage of the microprocessor that runs the SDR software. The net result favors a lower rate communication in terms of energy performance. To analyze the tradeoff quantitatively, this paper evaluates the computational complexity of SDR communication software by using BBN 802.11b implementation in GNU Radio. Moreover, for an extensive evaluation, we conducted the simulation study based on OPNET, which shows that JRF improves energy cost by as much as 78.0% compared to No Rate and Voltage Scaling (NoRVS) and as much as 51.3% compared to Independent Rate and Voltage Scaling (IRVS)

Joint Rate and Voltage Adaptation to Save Energy of Software Radios in Underutilized WLAN

This paper proposes an energy-saving bit-rate adaptation algorithm for Software-defined Radio (SDR)-based wireless systems, called Joint Rate and Voltage Fallback (JRF). It exploits the unused network time in underutilized networks by using a lower bit-rate than what an underlying rate adaptation algorithm such as Auto-rate Fallback (ARF) or Robust Rate Adaptation Algorithm (RRAA) dictates. While slow or low bitrate communication potentially consumes more energy due to its extended communication time, it saves energy in SDR due to the possibility of reducing the speed and the voltage of the microprocessor that runs the SDR software. The net result favors a lower rate communication in terms of energy performance. To analyze the tradeoff quantitatively, this paper evaluates the computational complexity of SDR communication software by using BBN 802.11b implementation in GNU Radio. Moreover, for an extensive evaluation, we conducted the simulation study based on OPNET, which shows that JRF improves energy cost by as much as 78.0% compared to No Rate and Voltage Scaling (NoRVS) and as much as 51.3% compared to Independent Rate and Voltage Scaling (IRVS)

Energy Efficient Wifi Tethering on a Smartphone

While numerous efforts have been made to save energy of “client” devices but it has not been addressed for access points (APs) as they are assumed to be supported by AC power. This paper proposes E-MAP, which is an energy saving algorithm for a tethering smartphone that plays a role of mobile AP (MAP) temporarily. It saves MAP\u27s energy by introducing the sleep cycle as in power save mode (PSM) in 802.11 but successfully keeps clients from transmitting while it sleeps. One important design goal of E-MAP is backward compatibility, i.e., it requires no modification on the client side and supports PSM and adaptive PSM (A-PSM) as well as normal constant awake mode (CAM) clients. Experiments show that E-MAP reduces the energy consumption of a Wifi tethering smartphone by up to 54% with a little impact on packet delay under various traffic patterns derived from real-life traces

Energy Efficient Wifi Tethering on a Smartphone

While numerous efforts have been made to save energy of “client” devices but it has not been addressed for access points (APs) as they are assumed to be supported by AC power. This paper proposes E-MAP, which is an energy saving algorithm for a tethering smartphone that plays a role of mobile AP (MAP) temporarily. It saves MAP\u27s energy by introducing the sleep cycle as in power save mode (PSM) in 802.11 but successfully keeps clients from transmitting while it sleeps. One important design goal of E-MAP is backward compatibility, i.e., it requires no modification on the client side and supports PSM and adaptive PSM (A-PSM) as well as normal constant awake mode (CAM) clients. Experiments show that E-MAP reduces the energy consumption of a Wifi tethering smartphone by up to 54% with a little impact on packet delay under various traffic patterns derived from real-life traces

Guided Tour of Handoff Steering for Bandwidth in Indoor Venues

With the advancement and development for more than two decades, WiFi has become an indispensable infrastructure in most of indoor venues. Indoor localization using this pre-existing infrastructure has been studied in the literature and is proven practically feasible, which mostly relies on WiFi fingerprints and the corresponding radiomap database. Since the radiomap essentially tells which APs are available and how strong their signals are at positions in the venue, this information can usefully utilized to “steer” to a better AP for the purpose of increasing the user throughput, which we call Guided Tour of Handoff Steering (GUT) in this paper. This steering is not much different from a conventional handoff, but it does not need an expensive scanning process owing to the radiomap, thus some additional handoffs are allowed than conventional handoffs. This leads to higher throughput, because a client can switch to a better AP whenever available. Based on an extensive experiment in a large-scale indoor venue of 119,685m2 with 1,734 APs, it is observed that GUT achieves as much as 84% higher throughput, but the number of handoffs increases only a few. This result supports that the handoff steering is not as expensive as the conventional handoff in terms of latency and traffic

Magmatic–hydrothermal processes in Sangdong W–Mo deposit, Korea: Study of fluid inclusions and 39 Ar– 40 Ar geochronology

The Sangdong scheelite-molybdenite deposit in northeast South Korea consists of strata-bound orebodies in intercalated carbonate-rich layers in the Cambrian Myobong slate formation. Among them, the M1 layer hosts the main orebody below which lie layers of F1-F4 host footwall orebodies. Each layer was first skarnized with the formation of a wollastonite + garnet + pyroxene assemblage hosting minor disseminated scheelite. The central parts of the layers were subsequently crosscut by two series of quartz veining events hosting minor scheelite and major scheelite-molybdenite ores, respectively. The former veins associate amphibole-magnetite (amphibole) alteration, whereas the latter veins host quartz-biotite-muscovite (mica) alteration. Deep quartz veins with molybdenite mineralization are hosted in the Cambrian Jangsan quartzite formation beneath the Myobong formation. In the Sunbawi area, which is in close proximity to the Sangdong deposit, quartz veins with scheelite mineralization are hosted in Precambrian metamorphic basement. Three muscovite Ar-39-Ar-40 ages between 86.6 +/- 0.2 and 87.2 +/- 0.3 Ma were obtained from M1 and F2 orebodies from the Sangdong deposit and Sunbawi quartz veins. The Upper Cretaceous age of the orebodies is concordant with the published ages of the hidden Sangdong granite, 87.5 +/- 4.5 Ma. This strongly suggests that the intrusion is causative for the Sangdong W-Mo ores and Sunbawi veins. Fluid inclusions in the quartz veins from the M1 and F2 orebodies, the deep quartz-molybdenite veins, and the Sunbawi veins are commonly liquid-rich aqueous inclusions having bubble sizes of 10-30 vol%, apparent salinities of 2-8 wt% NaCl eqv., and homogenization temperatures of 180-350 degrees C. The densities of the aqueous inclusions are 0.70-0.94 g/cm(3). No indication of fluid phase separation was observed in the vein. To constrain the formation depth in the Sangdong deposit, fluid isochores are combined with Ti-in-quartz geothermometry, which suggests that the M1 and F2 orebodies were formed at depths of 1-3 km and 5-6 km below the paleo-surface, respectively. The similarity of the Cs (cesium) concentrations and Rb/Sr ratios in the fluid inclusions of the respective orebodies indicate an origin from source magmas having similar degrees of fractionation and enrichment of incompatible elements such as W and Mo. High S concentrations in the fluids and possibly organic C in the sedimentary source likely promoted molybdenite precipitation in the Sangdong orebodies, whereas the scheelite deposition in the deep quartz-molybdenite veins hosted in the quartzite is limited by a lack of Ca and Fe in the hydrothermal fluids. The molybdenite deposition in the Sunbawi quartz-molybdenite veins hosted in the Precambrian metamorphic basement rocks was possibly limited by a lack of reducing agents such as organic C.N