6 research outputs found
Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, abeta, and alzheimer's disease.
- Author
- A David Smith
- Alan F Wright
- Bernadette McGuinness
- Caroline Hayward
- Chanley C Howell
- Chloe M Stanton
- Christopher M Watson
- Clive Holmes
- Curtis S Younkin
- David Craig
- David M Mann
- Dennis W Dickson
- Donald Warden
- Fanggeng Zou
- Harry Campbell
- Heike Kölsch
- Helen Beaumont
- Igor Rudan
- Kevin Morgan
- Kristelle Brown
- Li Ma
- Linda H Younkin
- Mariah R Kashino
- Mariet Allen
- Melissa E Howard
- Michael Crump
- Minerva M Carrasquillo
- Morad Ansari
- Neill R Graff-Radford
- Nicholas D Hastie
- Nilufer Ertekin-Taner
- Noor Kalsheker
- Olivia Belbin
- Olivia Belbin
- Ozren Polasek
- Patrick G Kehoe
- Peter Passmore
- Reinhard Heun
- Ronald C Petersen
- Samantha L Wilcox
- Samuel G Younkin
- Stephen Todd
- Steven G Younkin
- Toros A Dincman
- V Shane Pankratz
- Veronique Vitart
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2010
- Field of study
Background: The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD). Methodology/Principal findings: We examined conserved regions of IDE and its 10 kb flanks in 269 AD cases and 252 controls thereby identifying 17 putative functional polymorphisms. These variants formed eleven haplotypes that were tagged with ten variants. Four of these showed significant association with IDE transcript levels in samples from 194 LOAD cerebella. The strongest, rs6583817, which has not previously been reported, showed unequivocal association (p = 1.5x10(-8), fold-increase = 2.12,); the eleven haplotypes were also significantly associated with transcript levels (global p = 0.003). Using an in vitro dual luciferase reporter assay, we found that rs6583817 increases reporter gene expression in Be(2)-C (p = 0.006) and HepG2 (p = 0.02) cell lines. Furthermore, using data from a recent genome-wide association study of two Croatian isolated populations (n = 1,879), we identified a proxy for rs6583817 that associated significantly with decreased plasma Abeta40 levels (ss = -0.124, p = 0.011) and total measured plasma Abeta levels (b = -0.130, p = 0.009). Finally, rs6583817 was associated with decreased risk of LOAD in 3,891 AD cases and 3,605 controls. (OR = 0.87, p = 0.03), and the eleven IDE haplotypes (global p = 0.02) also showed significant association. Conclusions: Thus, a previously unreported variant unequivocally associated with increased IDE expression was also associated with reduced plasma Ass40 and decreased LOAD susceptibility. Genetic association between LOAD and IDE has been difficult to replicate. Our findings suggest that targeted testing of expression SNPs (eSNPs) strongly associated with altered transcript levels in autopsy brain samples may be a powerful way to identify genetic associations with LOAD that would otherwise be difficult to detect
Association and heterogeneity at the GAPDH locus in Alzheimer's disease
- Author
- Barrett
- Bertram
- Carrasquillo
- Chanley C. Howell
- Claire Cox
- Colell
- Dennis W. Dickson
- DerSimonian
- Ertekin-Taner
- Gatz
- Gina D. Bisceglio
- Harold
- Lambert
- Lee
- Li
- Li Ma
- Lin
- Lin
- Louise P. Walker
- Mariet Allen
- Mayeux
- McKhann
- Minerva M. Carrasquillo
- Myers
- Nakajima
- Neill R. Graff-Radford
- Newton-Cheh
- Nilüfer Ertekin-Taner
- Oliver Culley
- Olivia Belbin
- Reiman
- Rogaeva
- Ronald C. Petersen
- Samantha L. Wilcox
- Scott
- Steven G. Younkin
- Talisha A. Hunter
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
THE TOXIC PRESIDENCY OF GEORGE W. BUSH
- Author
- Aberbach Joel D.
- Abramowitz Alan L.
- Binder Sarah A.
- Bush George W.
- Bush George W.
- Bush George W.
- Bush George W.
- Bush George W.
- Chanley Virginia A.
- Cooper Phillip J.
- Cooper Phillip J.
- Edwards George C.
- Edwards Mickey
- Fiorina Morris P.
- Goldsmith Jack L.
- Herbert Jon
- Howell William G.
- Howell William G.
- Jacobson Gary C.
- Jon Herbert
- Klinkner P. A.
- Kurtz Howard
- Lipman-Blumen Jean
- Lipman-Blumen Jean
- Lipman-Blumen Jean
- Lipman-Blumen Jean
- Madsen Douglas
- Mcclellan Scott
- Mueller John
- Mutz Diana C.
- Newman Brian
- Ornstein Norman J.
- Pfiffner James P.
- Riker William H.
- Rudalevige Andrew
- Shapiro Robert Y.
- Sifton John
- Silverstein Gordon
- Thomas Evan
- Woodward Bob
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Perceived Ideological Distance and Trust in Congress*
- Author
- Aberbach Joel D.
- Abney F. Glenn
- Ansolabehere Stephen
- Banda Kevin K.
- Bandura Albert
- Bobo Lawrence
- Bowler Shaun
- Buchler Justin
- Campbell Angus
- Canes‐Wrone Brandice
- Chanley Virginia A.
- Citrin Jack
- Citrin Jack
- Cole Richard L.
- Conover Pamela Johnston
- Converse Philip E.
- Craig Stephen C.
- Delli Carpini Michael X.
- Downs Anthony
- Easton David
- Erber Ralph
- Fenno Richard F.
- Gamson William A.
- Gay Claudine
- Gerber Elisabeth R.
- Granberg Donald
- Hamill Ruth
- Harbridge Laurel
- Hetherington Marc J.
- Hetherington Marc J.
- Hetherington Marc J.
- Hetherington Marc J.
- Hetherington Marc J.
- Hibbing John R.
- Howell Susan E.
- Hurwitz Jon
- Jacobsmeier Matthew L.
- Jacoby William G.
- Jones David R.
- Jones Philip Edward
- Keele Luke
- Keele Luke
- Kropko Jonathan
- Kunda Ziva
- Levi Margaret
- Levi Margaret
- Miller Arthur H.
- Page Benjamin I.
- Rabinowitz George
- Rahn Wendy M.
- Richardson Lilliard E.
- Riggle Ellen D.
- Rosenstone Steven J.
- Rosenstone Steven J.
- Scherer Nancy
- Scholz John T.
- Scholz John T.
- Scholz John T.
- Sigelman Lee
- Stimson James A.
- Stokes Donald E.
- Taber Charles S.
- Tyler Tom R.
- Tyler Tom R.
- Wright John R.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Lichtabsorption von Lösungen im Ultraviolett und Sichtbaren
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- KW Hausser
- KW Hausser
- KW Hausser
- L Birkenbach
- L Brooker
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- L Cambi
- L Cambi
- L Dede
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- L Fuchs
- L Fuchs
- L Fuchs
- L Gyulai
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- L Heilmeyer
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- L Light
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- L Marchlewski
- L Marchlewski
- L Marchlewski
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- L Marchlewski
- L Marchlewski
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- L Michaelis
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- L Ruzicka
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- L Ruzicka
- L Ruzicka
- L Ruzicka
- L Ruzicka
- L Ruzicka
- L Ruzicka
- L Ruzicka
- L Ruzicka
- L Ruzicka
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- L Ruzicka
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- LGS Brooker
- LGS Brooker
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- LGS Brooker
- LH Dawson
- LJ Andrews
- LJ Andrews
- LJ Heidt
- LJ Heidt
- LJ Smith
- LL Engel
- LL Smith
- LN Ferguson
- LP Hammet
- LW Janssen
- LW Pickett
- LW Pickett
- LW Pickett
- M Abribat
- M Adler
- M Backès
- M Beznak
- M Bonnemay
- M Bonnemay
- M Calvin
- M Calvin
- M Calvin
- M Calvin
- M Chaix
- M Chaix
- M Chatelet
- M Chatelet
- M Chatelet-Lavollay
- M Crowe
- M Ehrenstein
- M Gerendas
- M Gerendas
- M Gex
- M Grumez
- M Grunfeld
- M Hinder
- M Karschulin
- M Kiese
- M Kofler
- M Kofler
- M Kofler
- M Kubota
- M Linhard
- M Martynoff
- M Müller
- M Orchin
- M Orchin
- M Padua
- M Paic
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Pestemer
- M Radvitchitch
- M Radvitchitch
- M Richter
- M Roy
- M Savart
- M Sorkin
- M Steiger
- M Sureau
- M Tolbert
- M Weltner
- MA Magill
- ME Laing McBain
- MG Pratt
- MH Stern
- MJ Grant
- MK Seikel
- ML Corrin
- ML Ernsberger
- ML Wolfrom
- MM Haring
- MM Janot
- MM Stimson
- MM Stimson
- MM Stimson
- MM Stimson
- MM Stimson
- MM Stimson
- MN Ljubimowa
- MS Kharasch
- MS Kharasch
- MS Mellon
- MTO Shaugnessy
- N Demassieux
- N Dichno
- N Gomez
- N Hellström
- N Mitra
- N Pace
- N Picus
- NA Milas
- NA Sörensen
- NA Waljaschko
- NA Waljaschko
- NA Waljaschko
- NA Waljaschko
- NA Waljaschko
- ND Coggeshall
- NE Nelson
- NH Coy
- NH Cromwell
- NI Gawrilow
- NJ Fisher
- NK De
- NL Frampton
- NW Turbin
- O Behaghel
- O Dann
- O Diels
- O Diels
- O Diels
- O Diels
- O Ehrismann
- O Hartleb
- O Isler
- O Jeger
- O Jeger
- O Jirovec
- O Kratky
- O Meyer
- O Oldenberg
- O Ruff
- O Schales
- O Schmidt
- O Schmidt
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Warburg
- O Wintersteiner
- O Wintersteiner
- OE Lanford
- OH Emerson
- OJ Walker
- OR Howell
- OV Shapiro
- OW Fialkowskaja
- P Bayard
- P Bernstein
- P Bovis
- P Bowden
- P Bowden
- P Bruylants
- P Bruylants
- P Csokan
- P Csokan
- P Csokan
- P Csokan
- P Franzen
- P Goldfinger
- P Grammaticakis
- P Grammaticakis
- P Grammaticakis
- P Großmann
- P Hegner
- P Job
- P Job
- P Job
- P Job
- P Job
- P Job
- P Job
- P Job
- P Job
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Karrer
- P Meunier
- P Müller
- P Niederhoff
- P Pratesi
- P Preiswerk
- P Preiswerk
- P Pringsheim
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ramart-Lucas
- P Ruggli
- P Steiner
- P Steiner
- P Vaillant
- PA Cole
- PA Cole
- PA Plattner
- PA Plattner
- PA Plattner
- PA Plattner
- PA Plattner
- PC Mukherji
- PC Mukherji
- PD Gorisontow
- PE Fanta
- PJ Brannigan
- PJ English
- PK Seshan
- PM Heertjes
- PM Heertjes
- PM Heertjes
- PN Chakravorty
- PN Chakravorty
- PW Seiwood
- PW Vittum
- Q Bartz
- R Chatterjee
- R Colmar
- R Dalmon
- R Dalmon
- R Dolique
- R Emerson
- R Goubau
- R Goutarel
- R Granit
- R Grewe
- R Grewe
- R Grinbaumnowna
- R Hauan
- R Havemann
- R Hüttel
- R Kremann
- R Kremann
- R Kremann
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Kuhn
- R Lal
- R Lemberg
- R Lemberg
- R Lucas
- R Mecke
- R Müller
- R Padmanabhan
- R Pummerer
- R Pummerer
- R Riegel
- R Samuel
- R Samuel
- R Samuel
- R Samuel
- R Samuel
- R Samuel
- R Schuh
- R Suhrmann
- R Suhrmann
- R Suhrmann
- R Titeica
- R Titeica
- R Titeica
- R Titeica
- R Tixier
- R Tréhin
- R Tréhin
- R Tréhin
- R Tréhin
- R Tréhin
- R Tscheche
- R Tscheche
- R Tsuchida
- R Tsuchida
- R Tsuchida
- R Tsuchida
- R Tsuchida
- R Tsuchida
- RA Bolomey
- RA Friedel
- RA Glading
- RA Morton
- RA Morton
- RA Morton
- RA Morton
- RA Morton
- RA Morton
- RA Peters
- RB Bourdillon
- RB Woodward
- RB Woodward
- RB Woodward
- RB Woodward
- RC Elderfield
- RC Fuson
- RC Gibbs
- RC Gibbs
- RC Gibbs
- RC Gibbs
- RC Gibbs
- RC Jones
- RC Merrill
- RD Hotchkiss
- RDH Heard
- RE Gibson
- RE Stuckey
- RF Hunter
- RF Raffauf
- RG Aickin
- RG Cooke
- RG Shepherd
- RH Ball
- RH Barnes
- RH Betts
- RH Levin
- RH Neal
- RH Potterill
- RH Potterill
- RJ Block
- RJ Colmar
- RJ Morris
- RK Asundi
- RK Bonnichsen
- RK Callow
- RM Costa
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RN Jones
- RO Herzog
- RP Mariella
- RR Williams
- RR Williams
- RT Holman
- RT Holman
- RT Holman
- RT Holman
- RT Holman
- RT O’Connor
- RW Mattoon
- RW Mattoon
- RW McKee
- S Aronoff
- S Barrat
- S Bergström
- S Bodforß
- S Bodforß
- S Datta
- S Datta
- S Datta
- S Dubois
- S Edmonds
- S Freed
- S Freed
- S Goldschmidt
- S Guinand
- S Guinand
- S Hattori
- S Hattori
- S Kashimoto
- S Kimura
- S Lajos
- S Menczel
- S Nawazish-Ali
- S Oguri
- S Prakash
- S Sambursky
- S Uyeo
- S-C Woo
- SA Glickman
- SA Schou
- SA Schou
- SC Woo
- SD Ross
- SE Sheppard
- SE Sheppard
- SE Sheppard
- SE Sheppard
- SK Crews
- SM Karim
- SM Karim
- SM Ssolowjew
- T Casperson
- T Casperson
- T Förster
- T Inoue
- T Maki
- T Milobedzki
- T Moore
- T Moore
- T Moore
- T Posternak
- T Reichstein
- T Reichstein
- T Reichstein
- T Svedberg
- T Tadokoro
- T Tsumaki
- T Uemura
- T Uemura
- T Uemura
- T Uemura
- T Wagner-Jauregg
- T-Y Wu
- TF Bradley
- TJ Webb
- TL Hill
- TM Lowry
- TM Lowry
- TM Lowry
- TM Meijer
- TM Meijer
- TR Hogness
- TR Wood
- TW Campbell
- U Westphal
- UV Solmssen
- V Alexa
- V Brustier
- V Brustier
- V Dolejsek
- V Hamon
- V Henri
- V Henri
- V Henri
- V Prelog
- V Prelog
- V Prelog
- V Prelog
- V Prelog
- V Prelog
- V Prelog
- V Prelog
- V Prelog
- V Sebesta
- V Sprecher
- VM Albers
- VM Albers
- VM Albers
- VN Ufimtzev
- VV Zelinski
- W Aumüller
- W Awe
- W Bednarczyk
- W Bednarczyk
- W Bednarczyk
- W Bergmann
- W Brüll
- W Dilthey
- W Dirscherl
- W Frankenburger
- W Gabryelski
- W Graßmann
- W Herold
- W Herold
- W Herold
- W Hieber
- W Hoppe
- W Huber
- W Huber
- W Hurka
- W Hückel
- W John
- W John
- W John
- W John
- W John
- W Kemula
- W Kern
- W Koch
- W Koschara
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W Kuhn
- W König
- W Mannecke
- W Menschick
- W Oroshnik
- W Prandtl
- W Schindler
- W Stenstrom
- W Theilacker
- W Trumpelt
- W Weyl
- WA Bonner
- WA Ismailski
- WA Ismailski
- WA Jacobs
- WA Jacobs
- WB Fortune
- WC Price
- WC Vosburgh
- WCG Baldwin
- WD Kumler
- WD Kumler
- WD Paiss
- WE Bachmann
- WE Tottingham
- WG Young
- WG Young
- WH Hunter
- WH Miller
- WH Rodebush
- Winterstein
- WJ Lyons
- WM Kutz
- WO Lundberg
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Brode
- WR Orndorff
- WR Orndorff
- WR Orndorff
- WR Orndorff
- WR Orndorff
- WR Orndorff
- WR Remington
- WV Bhagwat
- WV Bhagwat
- WV Mayneord
- WV Mayneord
- WW Robertson
- Y Hirshberg
- Y Schuttembach
- Y Shibata
- Y Tsuzuki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study