Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

<p>Abstract</p> <p>Background</p> <p>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to <it>Mycobacterium leprae</it>. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.</p> <p>Methods</p> <p>The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.</p> <p>Results</p> <p>The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.</p> <p>Conclusion</p> <p>HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.</p

Records of Pauropoda (Pauropodidae, Brachypauropodidae, Eurypauropodidae, Sphaeropauropodidae) from China, with a key to the species and descriptions of three new species of Decapauropus

Qian, Changyuan, Dong, Yan, Bernard, Ernest C., Sun, Hongying (2015): Records of Pauropoda (Pauropodidae, Brachypauropodidae, Eurypauropodidae, Sphaeropauropodidae) from China, with a key to the species and descriptions of three new species of Decapauropus. Zootaxa 4006 (3): 521-539, DOI: http://dx.doi.org/10.11646/zootaxa.4006.3.

A comparison of phase estimation in coherent optical PSK system

10.1109/IPGC.2008.47814422008 IEEE PhotonicsGlobal at Singapore, IPGC 2008

Suppression of polarization sensitivity in BOTDA fiber distributed sensing system

10.1117/12.785907Proceedings of SPIE - The International Society for Optical Engineering7004-PSIS