1 research outputs found
Fabrication and Characterization of Plasma-Polymerized Poly(ethylene glycol) Film with Superior Biocompatibility
A newly fabricated plasma-polymerized polyÂ(ethylene glycol)
(PP-PEG) film shows extremely low toxicity, low fouling, good durability,
and chemical similarity to typical PEG polymers, enabling live cell
patterning as well as various bioapplications using bioincompatible
materials. The PP-PEG film can be overlaid on any materials via the
capacitively coupled plasma chemical vapor deposition (CCP-CVD) method
using nontoxic PEG200 as a precursor. The biocompatibility of the
PP-PEG-coated surface is confirmed by whole blood flow experiments
where no thrombi and less serum protein adsorption are observed when
compared with bare glass, polyethylene (PE), and polyethylene terephthalate
(PET) surfaces. Furthermore, unlike bare PE films, less fibrosis and
inflammation are observed when the PP-PEG-coated PE film is implanted
into subcutaneous pockets of mice groin areas. The cell-repellent
property of PP-PEG is also verified via patterning of mammalian cells,
such as fibroblasts and hippocampal neurons. These results show that
our PP-PEG film, generated by the CCP-CVD method, is a biocompatible
material that can be considered for broad applications in biomedical
and functional materials fields