High-dose cytarabine monotherapy is superior to standard-dose cytarabine- based multiagent sequential treatment cycle for consolidation treatment in adult (14-59 years) AML patients according to European Leukemia Net 2022 risk stratification

IntroductionWe firstly investigate based on 2022 European Leukemia Net (ELN) risk stratification, whether standard-dose cytarabine based multiagent sequential chemotherapy (SDMSC) is more beneficial than high-dose cytarabine (HDAC) monotherapy in consolidation for the survival of adult acute myeloid leukemia (AML) patients.MethodsOne hundred and eighty-three AML patients with complete remission (CR) were evaluated.Results and discussionThe 3-year relapse rate was 33.4% in the HDAC group and 50.5% in the SDMSC group (p=0.066). The 3-year overall survival (OS) and event-free survival (EFS) rates in the HDAC group (69.2%, 60.7%) were significantly higher than that in the SDMSC group (50.8%, 42.1%) (p=0.025, 0.019). For patients in the intermediate risk group, the 3-year OS and EFS rates in the HDAC group (72.5%, 56.7%) were higher than that in the SDMSC group (49.1%, 38.0%) (p=0.028, 0.093). This study indicates that for young adult AML patients, HDAC consolidation achieves a higher long-term survival than SDMSC, especially for patients in the intermediate-risk group according to the 2022 ELN risk stratification

Evaluation of the Effectiveness of Clinical Pharmacists’ Consultation in the Treatment of Infectious Diseases: A Single-Arm, Prospective Cohort Study

Background: With the implementation of Antimicrobial Stewardship Program, clinical pharmacists’ consultation (CPC) for infectious diseases (ID) is gradually adopted by many hospitals in China. We conducted a cohort study to evaluate the effectiveness of CPC in ID treatment on patient outcomes and potential determinants.Methods: Based on a registry database, a prospective cohort study was conducted in Guizhou Provincial People’s Hospital. The main exposure factor was whether clinician adopted the suggestion from clinical pharmacist. The outcome was effective response rate (ERR) of ID patients. The variables associated with the outcome (e.g., age, gender, severity of infection, liver function, and kidney function) were also prospectively recorded. A multilevel model was performed to analyze the factors related to ERR.Results: A total of 733 ID inpatients were included in the final analysis according to the predesigned inclusion and exclusion criteria. The proportion of clinical pharmacists’ suggestions adopted by clinicians and ERR were 88.13 and 69.03%, respectively. Significant data aggregation (P < 0.05) for individuals at the level of department was observed. According to the two-level variance component model, liver dysfunction (Adjusted Odds Ratio (AOR) = 0.649, 95%Credible Interval (CI): 0.432–0.976), severity of infection (AOR = 0.602, 95%CI: 0.464–0.781), and adopting the suggestion from pharmacist (AOR = 1.738, 95%CI: 1.028–2.940) had significant association with ERR.Conclusion: Our study suggests that the effect of CPC on ID treatment is significant. The policy/decision makers or hospital managers should be cognizant of the critical value of clinical pharmacists in ID treatment

Nonlinear optical properties of zinc oxide

published_or_final_versionPhysicsDoctoralDoctor of Philosoph

Design method for throttle holes area of telescopic shock absorber tric Vehicles

Abstrac

Construction of a Teaching System Based on Big Data and Artificial Intelligence to Promote the Physical Health of Primary School Students

In recent years, although the overall physical health of Chinese students has shown an upward trend, the substantial decline in student physical fitness has been basically curbed. Most of the physical health indicators of students are steadily improving, but there are still many problems that need to be vigilant. In order to solve the problem of the decline of the physical health of primary school students, it is very important to construct a teaching system based on big data and artificial intelligence to promote the physical health of primary school students. This article aims to study from the actual situation and find scientific and reasonable methods to improve the physical health of primary school students. This article uses the literature method, questionnaire survey method, mathematical statistics method, and other research methods to analyze and study the current physical condition of the interviewed students and the actual influencing factors by taking students from 5 domestic primary schools as the research object. It is concluded that more than 90% of primary school students in Haidian District, Beijing, have good physique and physical development. The development level of strength and flexibility is gradually improved, but the speed and endurance quality are on the decline, especially the endurance quality of primary school boys has declined the most. Lack of good exercise habits, insufficient exercise time and exercise efficiency, and lack of appropriate exercise volume and necessary exercise intensity are currently the most important factors affecting the physical health of primary school students. The physical problems of primary school students are not caused by a single factor, but the result of multiple factors. This article puts forward a number of suggestions for the above situation and problems to be solved urgently

Microstructure and Bonding Strength of Low-Temperature Sintered Ag/Nano-Ag Films/Ag Joints

Nano-Ag paste is one of the most widely used die-attachment materials in modern electronic devices, which are gaining continuously increasing application in transportation industries. The nano-Ag film in a pre-formed dimension and free from the use of chemical dispersing agents has been proposed to be a promising alternative to nano-Ag paste for the die-attachment application. Although the bonding mechanisms of Nano-Ag paste have been extensively studied, little is known about the relationship between the microstructure and mechanical properties of low-temperature-sintered Ag/nano-Ag film/Ag joints. In this work, the influences of temperature, pressure, and dwell time at peak temperature on the microstructure and the shear strength of low-temperature-sintered Ag/nano-Ag film/Ag joints were systematically investigated. Mechanical properties tests indicate that both temperature and pressure have pronounced effects on the bonding strength of sintered Ag/nano-Ag film/Ag joints. TEM and hot nanoindentation characterizations further reveal that the sintering temperature plays the most determinant role in the coarsening of nano-Ag film and, hence, the bonding and fracture behaviors of Ag/nano-Ag film/Ag joints sintered at 210–290 °C. The diffusion-induced coarsening of nano-Ag particles can be activated, but remains sluggish at 250 °C, and the mechanical integrity of sintered joints is circumscribed by the interfacial bonding between nano-Ag film and Ag substrate after sintering at 290 °C