A MODEL ON AN ENTRAINED BED-BUBBLING BED PROCESS FOR CO2 CAPTURE FROM FLUE GAS

A simplified model has been developed to investigate effects of important operating parameters on performance of an entrained-bed absorber and bubbling-bed regenerator system collecting CO2 from flue gas. The particle population balance was considered together with chemical reaction to determine the extent of conversion in both absorber and regenerator. Effects of several absorber parameters was tested in a laboratory scale process. The CO2 capture efficiency decreased as temperature or gas velocity increased. However, it increased with static bed height or moisture concentration. The CO2 capture efficiency was exponentially proportional to each parameter. Based on the absolute value of exponent of the parameter, the effect of gas velocity, static bed height, and moisture content was a half, one third, and one fourth as strong as that of temperature, respectively

The Korea–United States Air Quality (KORUS-AQ) field study

The Korea–United States Air Quality (KORUS-AQ) field study was conducted during May–June 2016. The effort was jointly sponsored by the National Institute of Environmental Research of South Korea and the National Aeronautics and Space Administration of the United States. KORUS-AQ offered an unprecedented, multi-perspective view of air quality conditions in South Korea by employing observations from three aircraft, an extensive ground-based network, and three ships along with an array of air quality forecast models. Information gathered during the study is contributing to an improved understanding of the factors controlling air quality in South Korea. The study also provided a valuable test bed for future air quality–observing strategies involving geostationary satellite instruments being launched by both countries to examine air quality throughout the day over Asia and North America. This article presents details on the KORUS-AQ observational assets, study execution, data products, and air quality conditions observed during the study. High-level findings from companion papers in this special issue are also summarized and discussed in relation to the factors controlling fine particle and ozone pollution, current emissions and source apportionment, and expectations for the role of satellite observations in the future. Resulting policy recommendations and advice regarding plans going forward are summarized. These results provide an important update to early feedback previously provided in a Rapid Science Synthesis Report produced for South Korean policy makers in 2017 and form the basis for the Final Science Synthesis Report delivered in 2020

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Improving Rule Generation Precision for Domain Knowledge based Wrappers

Abstrac

Enhancing the Encoding-Forecasting Model for Precipitation Nowcasting by Putting High Emphasis on the Latest Data of the Time Step

Nowcasting is an important technique for weather forecasting because sudden weather changes significantly affect human life. The encoding-forecasting model, which is a state-of-the-art architecture in the field of data-driven radar extrapolation, does not particularly focus on the latest data when forecasting natural phenomena. This paper proposes a weighted broadcasting method that emphasizes the latest data of the time step to improve the nowcasting performance. This weighted broadcasting method allows the most recent rainfall patterns to have a greater impact on the forecasting network by extending the architecture of the existing encoding-forecasting model. Experimental results show that the proposed model is 1.74% and 2.20% better than the existing encoding-forecasting model in terms of mean absolute error and critical success index, respectively. In the case of heavy rainfall with an intensity of 30 mm/h or higher, the proposed model was more than 30% superior to the existing encoding-forecasting model. Therefore, applying the weighted broadcasting method, which explicitly places a high emphasis on the latest information, to the encoding-forecasting model is considered as an improvement that is applicable to the state-of-the-art implementation of data-driven radar-based precipitation nowcasting

The Downscaling Study for Typhoon-Induced Coastal Inundation

Typhoons can often cause inundation in lower coastal cities by inducing strong surges and waves. Being affected by typhoon annually, the coastal cities in South Korea are very vulnerable to typhoons. In 2016, a typhoon ‘CHABA’, with a maximum 10 min sustained wind speed of about 50 m/s and a minimum central pressure of 905 hPa, hit South Korea, suffering tremendous damage. In particular, ‘CHABA’-induced coastal inundation resulted in serious damage to the coastal area of Busan where a lot of high-rise buildings and residential areas are concentrated, and was caused by the combined effect of tide, surge, and wave. The typhoon-induced surge raised sea levels during high tide, and the strong wave with a long period of more than 10 s eventually led to the coastal inundation at the same time. The present research focuses a numerical downscaling considering the effects of tide, surge and wave for coastal inundation induced by Typhoon ‘CHABA’. This downscaling approach applied several numerical models, which are the Weather Research and Forecasting model (WRF) for typhoon simulation, the Finite Volume Community Ocean Model (FVCOM) for tide and surge simulation, and the Simulating WAve Nearshore (SWAN) for wave simulation. In a domain covering the Korean Peninsula, typhoon-induced surges and waves were simulated applying the results simulated by WRF as meteorological conditions. In the downscaled domain ranged near the coastal area of Busan, the coastal inundation was simulated blending a storm tide height and an irregular wave height obtained from the domain, in which each height has 1 s interval. The irregular wave height was calculated using the significant wave height and peak period. Through this downscaling study, the impact of storm tide and wave on coastal inundation was estimated

Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor

Neurofibromatosis type 1 (NF1) is an autosomal dominant human genetic disorder. The progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors (MPNSTs) is a major cause of mortality in patients with NF1. Although elevated epidermal growth factor receptor (EGFR) expression plays a crucial role in the pathogenesis of MPNST, the cause of EGFR overexpression remains unclear. Here, we assessed EGFR expression levels in MPNST tissues of NF1 patients and NF1 patient-derived MPNST cells. We found that the expression of EGFR was upregulated in MPNST tissues and MPNST cells, while the expression of neurofibromin was significantly decreased. Manipulation of NF1 expression by NF1 siRNA treatment or NF1-GAP-related domain overexpression demonstrated that EGFR expression levels were closely and inversely correlated with neurofibromin levels. Notably, knockdown of the NF1 gene by siRNA treatment augmented the nuclear localization of phosphorylated SP1 (pSP1) and enhanced pSP1 binding to the EGFR gene promoter region. Our results suggest that neurofibromin deficiency in NF1-associated MPNSTs enhances the Ras/ERK/SP1 signaling pathway, which in turn may lead to the upregulation of EGFR expression. This study provides insight into the progression of benign tumors and novel therapeutic approaches for treatment of NF1-associated MPNSTs