Status and Problems of Adverse Event Reporting Systems in Korean Hospitals

Objectives: This study identifies the current status and problems of adverse event reporting system in Korean hospitals. Thedata obtained from this study will be used to raise international awareness and enable collaborative researches on patientsafety. Methods: We distributed the questionnaire developed by the Agency for Healthcare Research and Quality (AHRQ),USA to the 265 risk managers of hospitals by e-mail. Seventy-two percent of the risk managers responded to the inquiry.Results: Eighty-five percent of the hospitals responded that they collect information regarding the event where harm hasoccurred or might have occurred to a patient. Seventy-five percent of the hospitals did not allow individuals to report occurrenceswithout identifying themselves. Only 54% of the hospitals had an organized patient safety program that manages orcoordinates all of the hospitals patient safety activities. The most frequent reason why errors were not reported was the fearof individuals being involved in the investigation and potential disadvantage resulting from it. Eighty-five percent of the hospitalsproduced reports of their adverse event data, but 68% of the hospitals did not distribute occurrence reports within thehospital. Conclusions: Lack of standardized reporting system, available information, procedures for protecting the reportingindividuals, and mindlessness/indifference of the hospital employees are identified as the major problems. Therefore, it iscrucial to address these problems to develop appropriate solutions, enable proactive involvement from the healthcare community,and change the overall patient safety culture, specifically protecting privacy, to increase the quality of service in thehealthcare industry.OAIID:oai:osos.snu.ac.kr:snu2010-01/102/0000028528/2SEQ:2PERF_CD:SNU2010-01EVAL_ITEM_CD:102USER_ID:0000028528ADJUST_YN:YEMP_ID:A076124DEPT_CD:811FILENAME:34 Status and Problems of Adverse Event Reporting Systems in Korean Hospitals.pdfDEPT_NM:간호학과EMAIL:[email protected]_YN:NCONFIRM:

Karyotype and nucleic acid content in Zantedeschia aethiopica Spr. and Zantedeschia elliottiana Engl.

Analysis of karyotype, nucleic deoxyribonucleic acid (DNA) content and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) were performed in Zantedeschia aethiopica and Zantedeschia elliottiana. Mitotic metaphase in both species showed 2n=32. The chromosomes of both species were quite similar with medium length ranging from 1.55 ± 0.04 to 3.85 ± 0.12 μM in Z. aethiopica and 2.15 ± 0.04 to 3.90 ± 0.12 μM in Z. elliottiana. However, some differences were found in morphology and centromeric position among the chromosomes. Identification of individual chromosomes was carried out using chromosomes length, and centromeric positions. The karyotype of Z. aethiopica was determined to be 2n = 32 = 14 m + 18 sm and of Z. elliottiana to be 2n = 32 = 10 m + 22 sm. The 2C nuclear DNA content was found to be 3.72 ± 0.10 picograms (equivalent to 3638.16 mega base pairs) for Z. aethiopica and 1144.26 ± 0.05 picograms (equivalent to 1144.26 mega base pairs) for Z. elliottiana. Leaf protein analysis showed 11 and 9 bands for Z. aethiopica and Z. elliottiana, respectively, among which some were species specific. These results may provide useful information regarding Zantedeschia for the study of taxonomic relationships, genetics and breeding.Keywords: Zantedeschia, karyotype, mitotic metaphase, chromosomes, flow cytometr

Limits of Binaries That Can Be Characterized by Gravitational Microlensing

Due to the high efficiency of planet detections, current microlensing planet searches focus on high-magnification events. High-magnification events are sensitive to remote binary companions as well and thus a sample of wide-separation binaries are expected to be collected as a byproduct. In this paper, we show that characterizing binaries for a portion of this sample will be difficult due to the degeneracy of the binary-lensing parameters. This degeneracy arises because the perturbation induced by the binary companion is well approximated by the Chang-Refsdal lensing for binaries with separations greater than a certain limit. For binaries composed of equal mass lenses, we find that the lens binarity can be noticed up to the separations of $\sim 60$ times of the Einstein radius corresponding to the mass of each lens. Among these binaries, however, we find that the lensing parameters can be determined only for a portion of binaries with separations less than $\sim 20$ times of the Einstein radius.Comment: 5 pages, 3 figures, 1 tabl

Skin care benefits of bioactive compounds isolated from Zanthoxylum piperitum DC. (Rutaceae)

Purpose: To investigate skin care efficacies of Zanthoxylum pipetitum extract and isolated compounds. Methods: Ethanol extracts of leaves, branches and fruits of what were partitioned into n-hexane, chloroform, ethyl acetate, n-butanol and aqueous layers and some fractions were further analyzed to isolate five compounds. The isolated compounds were identified based on the proton and carbon nuclear magnetic resonance (NMR) spectra. Cosmetic efficacy tests of the extracts and isolated compounds were evaluated by in vitro tests. Results: Phytochemical studies of the chloroform and ethyl acetate layers led to the isolation of five compounds; quercitrin (1), afzelin (2), hydroxy-α-sanshool (3), α-sanshool (4) and hyperoside (5). In activity tests, the extracts showed inhibitory activity against inflammation response and melanin synthesis, and induction of procollagen type I C-peptide (PIP). Among the isolated compounds, hydroxy-α-sanshool (3) and α-sanshool (4) displayed significant anti-inflammatory activity. Conclusion: The results demonstrate that Z. piperitum extract and its active compounds possess a significant potential as a cosmeeutical agent for enhancing skin quality

The Fruit Hull of Gleditsia sinensis

Lung cancer has substantial mortality worldwide, and chemotherapy is a routine regimen for the treatment of patients with lung cancer, despite undesirable effects such as drug resistance and chemotoxicity. Here, given a possible antitumor effect of the fruit hull of Gleditsia sinensis (FGS), we tested whether FGS enhances the effectiveness of cis-diammine dichloridoplatinum (II) (CDDP), a chemotherapeutic drug. We found that CDDP, when administered with FGS, significantly decreased the viability and increased the apoptosis and cell cycle arrest of Lewis lung carcinoma (LLC) cells, which were associated with the increase of p21 and decreases of cyclin D1 and CDK4. Concordantly, when combined with FGS, CDDP significantly reduced the volume and weight of tumors derived from LLC subcutaneously injected into C57BL/6 mice, with concomitant increases of phosphor-p53 and p21 in tumor tissue. Together, these results show that FGS could enhance the antitumor activity of CDDP, suggesting that FGS can be used as a complementary measure to enhance the efficacy of a chemotherapeutic agent such as CDDP