Intensity Mapping with Carbon Monoxide Emission Lines and the Redshifted 21 cm Line

We quantify the prospects for using emission lines from rotational transitions of the CO molecule to perform an `intensity mapping' observation at high redshift during the Epoch of Reionization (EoR). The aim of CO intensity mapping is to observe the combined CO emission from many unresolved galaxies, to measure the spatial fluctuations in this emission, and use this as a tracer of large scale structure at very early times in the history of our Universe. This measurement would help determine the properties of molecular clouds -- the sites of star formation -- in the very galaxies that reionize the Universe. We further consider the possibility of cross-correlating CO intensity maps with future observations of the redshifted 21 cm line. The cross spectrum is less sensitive to foreground contamination than the auto power spectra, and can therefore help confirm the high redshift origin of each signal. Furthermore, the cross spectrum measurement would help extract key information about the EoR, especially regarding the size distribution of ionized regions. We discuss uncertainties in predicting the CO signal at high redshift, and discuss strategies for improving these predictions. Under favorable assumptions, and feasible specifications for a CO survey mapping the CO(2-1) and CO(1-0) lines, the power spectrum of CO emission fluctuations and its cross spectrum with future 21 cm measurements from the MWA are detectable at high significance.Comment: 19 pages, 8 figures, submitted to Ap

Management of Elbow Dislocations in the National Football League.

Background: Although much literature exists regarding the treatment and management of elbow dislocations in the general population, little information is available regarding management in the athletic population. Furthermore, no literature is available regarding the postinjury treatment and timing of return to play in the contact or professional athlete. Purpose: To review the clinical course of elbow dislocations in professional football players and determine the timing of return to full participation. Study Design: Case series; Level of evidence, 4. Methods: All National Football League (NFL) athletes with elbow dislocations from 2000 through 2011 who returned to play during the season were identified from the NFL Injury Surveillance System (NFL ISS). Roster position, player activity, use of external bracing, and clinical course were reviewed. Mean number of days lost until full return to play was determined for players with elbow dislocations who returned in the same season. Results: From 2000 to 2011, a total of 62 elbow dislocations out of 35,324 injuries were recorded (0.17%); 40 (64.5%) dislocations occurred in defensive players, 12 (19.4%) were in offensive players; and 10 (16.1%) were during special teams play. Over half of the injuries (33/62, 53.2%) were sustained while tackling, and 4 (6.5%) patients required surgery. A total of 47 (75.8%) players who sustained this injury were able to return in the same season. For this group, the mean number of days lost in players treated conservatively (45/47) was 25.1 days (median, 23.0 days; range, 0.0-118 days), while that for players treated operatively (2/47) was 46.5 days (median, 46.5 days; range, 29-64 days). Mean return to play based on player position was 25.8 days for defensive players (n = 28; median, 21.5 days; range, 3.0-118 days), 24.1 days for offensive players (n = 11; median, 19 days; range, 2.0-59 days), and 25.6 days for special teams players (n = 8; median, 25.5 days; range, 0-44 days). Conclusion: Elbow dislocations comprise less than a half of a percent of all injuries sustained in the NFL. Most injuries occur during the act of tackling, with the majority of injured athletes playing a defensive position. Players treated nonoperatively missed a mean of 25.1 days, whereas those managed operatively missed a mean of 46.5 days

Sex Differences in Health Related Quality of Life in Head & Neck Cancer One Year After Treatment

Background: Head and neck cancer (HNC) makes up about 3% of all cancers and is treated with systemic therapy, radiation, surgery, or a combination of these. HNC treatment can be associated with decreased patient reported health related quality of life (HR-QoL), which can lead to depression. The majority of studies found that females reported worse patient reported HR-QoL than males, however, there were a few that did not have a significant difference in overall patient reported QoL. With the discovery of patient oriented outcomes (PROs) in clinical practice affecting patient satisfaction, provider-patient relationship, and overall patient mortality, it is vital to include PROs in the creation of treatment plans. Objectives: The objectives of this project are to highlight the differences in HR-QoL between men and women. Ultimately, using these PROs clinically will help to improve patient care, augment patient-provider trust, and optimize treatment plans. Using PROs and recognizing where unconscious biases of providers come into play is pinnacle, and this project aims to highlight how men and women\u27s experiences are different in the treatment of HNC. Methods: Participants were given the FACT-H&N instrument one year after treatment for head and neck cancer at a single tertiary academic center to assess different aspects of Hr-QoL. Sex differences were analyzed between the groups. A Wilcoxon Rank Sum test was performed to assess associations with sex and survey responses, as well as to assess associations with total laryngectomy and survey responses. Results: There were 100 participants from a single academic center of which 73% were men and 27% women. Several of the questions had significant differences between men and women: I feel ill (P=0.0299), I am satisfied with my family communication about my illness P=0.0075), I am satisfied with my sex life (P=0.0496), My voice has its usual quality and strength (P=0.0057), I can swallow naturally and easily (P=0.0437), and I can eat solid foods (P=0.0248). There were no significant differences between men and women with laryngectomies. Conclusions: Overall, men felt more ill, were less satisfied with their sex lives, were less likely to feel a normal strength and quality of voice, felt decreased ability to swallow normally, and felt they could not eat solid foods; women were less satisfied with communication about their disease to their families. For those who had undergone laryngectomy, there were no significant differences between men and women. Different aspects of quality of life for men and women are affected by head and neck cancer. Monitoring PROs are becoming increasingly standard of care for patients, and providers need to be equipped understand how to interpret data accordingly and understand the inherent biases

Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization

Exposure to cigarette smoke is a major risk factor for head and neck squamous cell carcinoma (HNSCC). We have previously established a chronic cigarette smoke extract (CSE)-treated human oral normal keratinocyte model, demonstrating an elevated frequency of mitochondrial mutations in CSE treated cells. Using this model we further characterized the mechanism by which chronic CSE treatment induces increased cellular proliferation.We demonstrate that chronic CSE treatment upregulates PDK2 expression, decreases PDH activity and thereby increases the glycolytic metabolites pyruvate and lactate. We also found that the chronic CSE treatment enhanced HIF1α accumulation through increased pyruvate and lactate production in a manner selectively reversible by ascorbate. Use of a HIF1α small molecule inhibitor blocked the growth induced by chronic CSE treatment in OKF6 cells. Furthermore, chronic CSE treatment was found to increase ROS (reactive oxygen species) production, and application of the ROS scavengers N-acetylcysteine abrogated the expression of PDK2 and HIF1α. Notably, treatment with dichloroacetate, a PDK2 inhibitor, also decreased the HIF1α expression as well as cell proliferation in chronic CSE treated OKF6 cells.Our findings suggest that chronic CSE treatment contribute to cell growth via increased ROS production through mitochondrial mutations, upregulation of PDK2, attenuating PDH activity thereby increasing glycolytic metabolites, resulting in HIF1α stabilization. This study suggests a role for chronic tobacco exposure in the development of aerobic glycolysis and normoxic HIFα activation as a part of HNSCC initiation. These data may provide insights into development of chemopreventive strategies for smoking related cancers

Noncommutative Field Theory from twisted Fock space

We construct a quantum field theory in noncommutative spacetime by twisting the algebra of quantum operators (especially, creation and annihilation operators) of the corresponding quantum field theory in commutative spacetime. The twisted Fock space and S-matrix consistent with this algebra have been constructed. The resultant S-matrix is consistent with that of Filk\cite{Filk}. We find from this formulation that the spin-statistics relation is not violated in the canonical noncommutative field theories.Comment: 13 pages, 1 figure, minor changes, add reference

Time-Series Causality with Missing Data

Over the past years, researchers have proposed various methods to discover causal relationships among time-series data as well as algorithms to fill in missing entries in time-series data. Little to no work has been done in combining the two strategies for the purpose of learning causal relationships using unevenly sampled multivariate time-series data. In this paper, we examine how the causal parameters learnt from unevenly sampled data (with missing entries) deviates from the parameters learnt using the evenly sampled data (without missing entries). However, to obtain the causal relationship from a given time-series requires evenly sampled data, which suggests filling the missing data values before obtaining the causal parameters. Therefore, the proposed method is based on applying a Gaussian Process Regression (GPR) model for missing data recovery, followed by several pairwise Granger causality equations in Vector Autoregssive form to fit the recovered data and obtain the causal parameters. Experimental results show that the causal parameters generated by using GPR data filling offers much lower RMSE than the dummy model (fill with last seen entry) under all missing values percentage, suggesting that GPR data filling can better preserve the causal relationships when compared with dummy data filling, thus should be considered when dealing with unevenly sampled time-series causality learning

Socioeconomic Determinants of Survival in Laryngeal Squamous Cell Carcinoma Patients

Objective: To determine whether comorbidities, socioeconomic factors, and race affect median survival times and overall survival outcomes for patients with laryngeal squamous cell carcinoma treated at a single institution with a large African American population. Study Design: Retrospective cohort study Setting: Tertiary care medical center. Subjects and Methods: Six-hundred nineteen patients treated for laryngeal squamous cell carcinoma at a single institution between 1999 and 2013. Kaplan-Meier survival curve analysis and Cox proportional hazard models were used. Results: Median survival time decreased with age ≥ 65 years (P \u3c .001), stage 3 or 4 (P \u3c .001),clinical T stage 3 or 4 (P \u3c .001), and clinical N stage 1, 2, or 3 (P \u3c .001). Living in zip code with increasing proportion of residents with high school degree or less (P \u3c .001),increasing proportion of residents living below the poverty level (P \u3c .001), and increasing Charlson Comorbidity Index (P \u3c .001) were associated with increased risk of death. Increasing median household income was associated with decreased increased risk of death (P \u3c .001). Caucasian, rather than African American, race was associated with decreased median survival time (P = .01). Conclusion: Socioeconomic factors and medical comorbidities were negative prognostic indicators of survival in patients with laryngeal squamous cell carcinoma. Contrary to previous reports, African American race was associated with improved overall survival in univariate analysis. However, once socioeconomic factors were controlled for, race conferred no effect on survival. Rather, living in neighborhoods with higher median household income was protective.https://scholarlycommons.henryford.com/merf2019hcd/1001/thumbnail.jp