1,144 research outputs found
Exploring doctors' willingness to provide online counseling services : the roles of motivations and costs
With the impetus of information communication technology (ICT), emerging eHealth has attracted increasing number of doctors’ participation in online health platforms, which provide various potential benefits to doctors. However, previous studies on eHealth have seldom distinguished different service modes provided by doctors. In addition, the bulk of the literature has considered doctors’ motivations based solely on online environments. To fill this gap, this study combines expectancy theory and the Bagozzi, Dholakia, and Basuroy (BDB) model to examine the relationships between anticipated outcomes, performance expectations, and effort intentions from online and offline perspectives. Doctors’ behavioral intentions are further divided into two categories: the willingness to offer free services and paid services. Using SmartPLS, this study conducts structural equation modeling (SEM) to analyze 311 sample data. The results show that extrinsic motivations (i.e., extrinsic rewards, expected relationships, and image) and intrinsic motivation (i.e., a sense of self-worth) significantly influence the desire to serve patients well, which in turn positively affects the willingness to offer free services and the willingness to offer paid services. Moreover, counseling time is confirmed as the main cost, which negatively moderates the relationships between desire and behavioral intentions. The findings provide theoretical insights for eHealth and provide practical suggestions to develop marketing strategies for online health platform providers
Learning Semantic Textual Similarity via Topic-informed Discrete Latent Variables
Recently, discrete latent variable models have received a surge of interest
in both Natural Language Processing (NLP) and Computer Vision (CV), attributed
to their comparable performance to the continuous counterparts in
representation learning, while being more interpretable in their predictions.
In this paper, we develop a topic-informed discrete latent variable model for
semantic textual similarity, which learns a shared latent space for
sentence-pair representation via vector quantization. Compared with previous
models limited to local semantic contexts, our model can explore richer
semantic information via topic modeling. We further boost the performance of
semantic similarity by injecting the quantized representation into a
transformer-based language model with a well-designed semantic-driven attention
mechanism. We demonstrate, through extensive experiments across various English
language datasets, that our model is able to surpass several strong neural
baselines in semantic textual similarity tasks.Comment: 12 pages, 6 figure
BIOMECHANICAL EFFECT OF GROUP EXERCISE PROGRAM USING STABILITY BALL ON THE COUNTER MOVEMENT JUMP
The purpose of this study was to evaluate the training effect of three-month group exercise program using stability ball. Ten female subjects were recruited to join this group exercise class for three months. The biomechanical parameters of counter-movement jump were collected before and after class. The average of maximal jumping height and the take-off velocity have significantly increased after three months. The group exercise program accoring American College of Sport Medicine trainig guideline which was designed in this study was helpful to increase the jump height of counter movement jump and to improve the biomechanical parameters of the landing
Buyers’ psychological situations in cross-border electronic commerce
Cross-border electronic commerce (CBEC) has emerged as an innovative business model that transforms consumer behaviour and mindsets, in the era of digitalization and globalization. Buyer situations in CBEC are complex due to the separation of global sellers and buyers in terms of geographic distance, language and cultural differences, and buyer preferences. However, few studies have explored buyers’ shopping decisions from a situational perspective. Drawing on the stimulus–organism–response framework, this study conceptualizes a CBEC buyer shopping model that theorizes four psychological situational factors (i.e., CBEC platform design, user–platform interaction, logistics evaluation, and task orientation) as stimuli, cognitive and affective states as organisms, and shopping intention as a response. The model was empirically tested using 241 data through structural equation modelling. The results indicate that all situational factors positively affect two evaluative states, which in turn positively affect shopping intention. Implications for theory and practice are discussed
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction with 3' ends of Japanese encephalitis virus RNA and colocalization with the viral NS5 protein
Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of viral replication. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a cellular metabolic protein, was found to colocalize with viral RNA-dependent RNA polymerase (NS5) in JEV-infected cells. Subcellular fractionation further indicated that GAPDH remained relatively constant in the cytosol, while increasing at 12 to 24 hours postinfection (hpi) and decreasing at 36 hpi in the nuclear fraction of infected cells. In contrast, the redistribution patterns of GAPDH were not observed in the uninfected cells. Co-immunoprecipitation of GAPDH and JEV NS5 protein revealed no direct protein-protein interaction; instead, GAPDH binds to the 3' termini of plus- and minus-strand RNAs of JEV by electrophoretic mobility shift assays. Accordingly, GAPDH binds to the minus strand more efficiently than to the plus strand of JEV RNAs. This study highlights the findings that infection of JEV changes subcellular localization of GAPDH suggesting that this metabolic enzyme may play a role in JEV replication
An Unexpected Cause of a Subcutaneous Nodule: A Case Report of Dirofilaria Infection
Humans are not natural hosts of Dirofilaria; however, pulmonary or subcutaneous infections may occur through mosquitoes transmission. Patients presenting with simple subcutaneous nodules may not seek early medical attention, and hence systemic involvement through hematogenous spread may occur. Definitive diagnosis of Dirofilaria infection is made by histopathological examinations of the infected tissues. We report a patient with an incidental diagnosis of Dirofilaria infection confirmed by histopathological findings of a subcutaneous nodule on the right thigh. The source of infection remains unknown
Strategies for Searching Video Content with Text Queries or Video Examples
The large number of user-generated videos uploaded on to the Internet
everyday has led to many commercial video search engines, which mainly rely on
text metadata for search. However, metadata is often lacking for user-generated
videos, thus these videos are unsearchable by current search engines.
Therefore, content-based video retrieval (CBVR) tackles this metadata-scarcity
problem by directly analyzing the visual and audio streams of each video. CBVR
encompasses multiple research topics, including low-level feature design,
feature fusion, semantic detector training and video search/reranking. We
present novel strategies in these topics to enhance CBVR in both accuracy and
speed under different query inputs, including pure textual queries and query by
video examples. Our proposed strategies have been incorporated into our
submission for the TRECVID 2014 Multimedia Event Detection evaluation, where
our system outperformed other submissions in both text queries and video
example queries, thus demonstrating the effectiveness of our proposed
approaches
Prevention and early management of carotid blowout syndrome for patients receiving head and neck salvage boron neutron capture therapy (BNCT)
Background/purpose
The incidence rate of oral and pharyngeal cancers in Taiwan has increased gradually over the past few decades. The standard treatment strategy for oral and pharyngeal cancers includes surgery or radiotherapy, with concurrent chemotherapy in certain types of tumors. Unfortunately, in-field recurrence is sometimes inexorable. Furthermore, re-irradiation of the recurrence site may cause severe complications due to the tolerance of normal tissue to radiation therapy. One fatal complication is carotid blowout syndrome (CBS). Boron neutron capture therapy (BNCT) is a new modality of radiation therapy, which is also mentioned as targeted radiotherapy. It is a feasible treatment that has the potential to spare normal tissue from being damaged by irradiation while simultaneously treating the primary tumor. In this presentation, we will share our experience with BNCT in treating recurrent head and neck cancers, as well as the prevention and management of CBS.
Materials and methods
We evaluated 4 patients with head and neck cancers treated by BNCT in Taiwan. All patients had undergone surgery previously and had received postoperative concurrent chemoradiotherapy.
Results
The 4 patients in this study were diagnosed with head and neck malignancies. The median follow-up period after the first course of BNCT was 15.1 months. After BNCT, 2 patients developed impending CBS, and 1 of them died. The remaining 3 patients survived until the last date of follow-up.
Conclusion
Pre-BNCT carotid artery evaluation through computed tomography angiography and early intervention if necessary is crucial when treating patients with recurrent head and neck cancers by BNCT
Effects of mycophenolate mofetil on cutaneous lupus erythematosus in (NZB × NZW) F1 mice
AbstractBackgroundFew studies have evaluated the effects and precise molecular mechanism of mycophenolate mofetil (MMF) in the treatment of human cutaneous lupus erythematosus (CLE). Our findings shed light on the therapeutic effects of MMF in a UVB-induced NZB × NZW (NZBW) F1 CLE mouse model.MethodsContinuous MMF treatment (60 mg/kg/day) was administered up to Day 50 from the beginning of UVB induction (Day 0; 20 weeks old), as the pathologic features of CLE are present after 50 days. The therapeutic effects of MMF treatment in NZBW lupus mice were examined by comparing histopathological changes, lupus band test (deposition of immune complexes at the dermal–epidermal junction) and colocalization of autoantibodies with a dermal autoantigen Dsg3, and by evaluating the associations of local matrix metalloprotease activities.ResultsMMF improved survival in the NZBW lupus mice from 35.7% to 81.8%. The proteinuria, blood urea nitrogen, and interleukin 6 levels were significantly reduced after MMF treatment. The dermal lymphocytic infiltration, deposition of immune complexes at the dermal–epidermal junction, colocalized autoantibodies with Dsg3, and epidermal matrix metalloprotease activity were also attenuated in MMF-treated NZBW F1 mice.ConclusionThe results confirmed that MMF could substantially attenuate skin damage due to CLE in the NZBW F1 mouse model
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