Flowers For The World: Developing a Business Game to Support the Teaching of IS Concepts

One of the key problems in teaching fundamental concepts in information systems is how to ground the theory in experiences that the students can relate to. To overcome this problem, a business game called Flowers For The World has been developed and used across a wide variety of IS courses. This paper will describe the game and the result of using it for a 300-level course in analysis and design. The possibility exists that the game could be developed to provide a common business foundation across all business school curricula

Understanding the Influence of Blog on the Development of Social Capital

The rapid use and application of blogs in diverse areas such as education, marketing, journalism, and human resource management in recent years underlines the need for a better understanding of the impact of this new technology on social capital. Social capital reflects the norm of reciprocity and the level of trust among individuals who connect, interact, and benefit from one another. Blog is expected to influence the extent and the scope of this interaction by providing new means of networking among people. This paper examines the relationship between blog use and social capital and reports on the results of an exploratory study that examines this relationship using survey data from 326 blog users. Results suggest a significant and positive impact of blog use on social capital and its components: social connections, reciprocity, and trust. Implications of these findings for research and practice are discussed

The development and test of a relationship model on system use, job learning, and impact

This exploratory study examined the role of job learning on the relationship between information systems use and impact. Data from 308 end-users were analyzed to evaluate the relationship between systems use, job learning, and technology impact. System use was conceptualized as decision support, work integration, and customer service. Technology impact was conceptualized as effect on management control, task innovation, task productivity, and customer satisfaction. Two sets of hypotheses are presented for these relationships. Results suggest that the pattern of system use significantly and positively influenced job learning. Job learning was found to significantly and positively influence technology impact. We theorize that individuals learned about their job as a result of systems usage. In turn, job learning influenced technology impact. The study findings are discussed

Clarifying the Role of Self-Efficacy and Metacognition as Indicators of Learning: Construct Development and Test

We propose extending our understanding of self-efficacy by comparing self-efficacy with a related construct called metacognition. Metacognition involves the monitoring and control of one\u27s thought processes and is often related, as is self-efficacy, to performance on a task. We develop an instrument that attempts to measure both self-efficacy and metacognition with respect to one\u27s performance on a test covering declarative and procedural knowledge (knowing that, and knowing how) of DFDs and ERDs. With data collected from a sample of 124 students, we use partial least squares (PLS) to show that self-efficacy and metacognition are distinct yet related constructs. While self-efficacy is a predictor of both declarative and procedural knowledge, metacognition is only related to procedural knowledge. We discuss the implications of these results and suggest further research is needed to compare and contrast the role of these constructs in assessing learning outcomes

Formative versus reflective measurement: Comment on Marakas, Johnson, and Clay (2007)

In a recent issue of the Journal of the Association for Information Systems, Marakas, Johnson, and Clay (2007) presented an interesting and important discussion on formative versus reflective measurement, specifically related to the measurement of the computer self-efficacy (CSE) construct. However, we believe their recommendation to measure CSE constructs using formative indicators merits additional dialogue before being adopted by researchers. In the current study we discuss why the substantive theory underlying the CSE construct suggests that it is best measured using reflective indicators. We then provide empirical evidence demonstrating how the misspecification of existing CSE measures as formative can result in unstable estimates across varying endogenous variables and research contexts. Specifically, we demonstrate how formative indicator weights are dependent on the endogenous variable used to estimate them. Given that the strength of formative indicator weights is one metric used for determining indicator retention, and adding or dropping formative indicators can result in changes in the conceptual meaning of a construct, the use of formative measurement can result in the retention of different indicators and ultimately the measurement of different concepts across studies. As a result, the comparison of findings across studies over time becomes conceptually problematic and compromises our ability to replicate and extend research in a particular domain. We discuss not only the consequences of using formative versus reflective measures in CSE research but also the broader implications this choice has on research in other domains

Prepare your mind for learning

The learning process must evolve and expand throughout one\u27s IT career. Most would agree that\u27s often easier said than done. Here are some ways professionals can overcome mental blocks that may prevent learning

Clarifying the Use of Formative Measurement in the IS Discipline: The Case of Computer Self-Efficacy

The article offers insights on the use of formative measurement in the information system (IS) discipline. It focuses on the comment which warns researchers on the pitfalls of misapplying formative measures in information system domain as well as on the issues related to computer self-efficacy (CSE) and formative measurement. It then asserts that formative indicator weights are sued in determining the conceptual meaning of constructs and notes that the conceptual definition of CSE will likely differ as they are used in different research models and contexts

Comparing Self-Efficacy and Metacognition as Indicators of Performance

We report the results of a pilot study that compared the computer self-efficacy construct with metacognition. While self-efficacy is primarily affective and refers to one’s beliefs about one’s ability to perform a task, metacognition is primarily cognitive and refers to one’s thoughts about one’s ability to perform a task. Given their similarity, both have been used as surrogate measures of knowledge or skill. We developed an instrument to measure both constructs and applied the instrument to a set of MIS students taking an Analysis and Design course. Factor analysis produced a five-factor model, with metacognition factoring out as a unidimensional scale. Implications for further research are discussed

Management of Change to Ensure IS Success: A Longitudinal Study

This paper aims to understand the effect of management of change on the success of information system (IS) implementation. Drawing on change management research and self-determination theory, a research model is developed. Data collected from a longitudinal field survey before, during, and after an enterprise-wide IS implementation are analyzed to test the proposed hypotheses. The results indicate that management of change can be used to increase readiness for change and end-user computing satisfaction during and after the implementation. Readiness for change positively impacts satisfaction during an implementation but not after. Contrary to the literature, No significant relationship exists between resistance to change and satisfaction. The paper contributes to IS research and practice by drawing attention to the importance of management of change and readiness for change for IS success

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival