Demographic, clinical and laboratory findings children with cerebral malaria alone (CM) or severe malarial anemia alone (SMA) on admission.

<p>Demographic, clinical and laboratory findings children with cerebral malaria alone (CM) or severe malarial anemia alone (SMA) on admission.</p

Demographic, clinical and laboratory findings children with cerebral malaria (CM) who survived vs. died.

<p>Demographic, clinical and laboratory findings children with cerebral malaria (CM) who survived vs. died.</p

Study enrollment and testing for lactic acidosis.

<p>Study enrollment and testing for lactic acidosis.</p

Demographic characteristics of the children.

1<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055653#s3" target="_blank">Results</a> indicate frequency, N (%); HOME = Home observation for the measurement of the environment; N = Number; M = Mean; SD = Standard deviation.</p

Unadjusted plasma 25(OH)D concentrations in Ugandan children with severe malaria (n = 40) and in healthy community children (n = 20).

<p>The dotted line at 30 ng/mL indicates the cutoff for vitamin D insufficiency, and the dotted line at 20 ng/mL indicates the cutoff for vitamin D deficiency. Dashed lines reflect mean 25(OH)D value for each study group.</p

Standardized estimates of regression coefficients on the ‘Cognitive ability’ latent variable.

<p>Standardized estimates of regression coefficients on the ‘Cognitive ability’ latent variable.</p

Regression coefficients with and without adjusters, excluding other cognitive measures.

*<p>“unadj” is from the unadjusted analysis using a single cognitive scale; “5 adj” is from the analysis using a single cognitive scale adjusting for age, sex, home environment, education level, and weight-for-age z score.</p

Estimates of regression coefficients of an outcome on a scale residual.

<p>Estimates of regression coefficients of an outcome on a scale residual.</p

Number and percentages of responders to tetanus toxoid (TT) as assessed by specific memory B cells and immunoglobulin G (IgG) antibodies (Ab) in April 2009.

<p>McNemar’s test, <i>P = </i>0.71.</p

The gating strategy for identifying the B cell subpopulations.

<p>We first gated on the live (DAPI⁻) lymphocytes and then collected 10,000 events of CD19+. These were analyzed for expression of IgD, CD27, CD21, IgM and FcRL4. CD19+ lymphocytes were classified as naïve (IgD+CD27-) B cells, non class-switched (IgD+CD27+) MBCs, classical (IgD-CD27+) MBCs and double negative (IgD-CD27-) MBCs. MBC subtypes were further defined as follows: 1. Resting classical MBCs: CD19+IgD-CD27+CD21+. 2. Activated MBCs: CD19+IgD-CD27+CD21-. 3. Atypical MBCs: CD19+IgD-CD27-CD21- MBCs.</p