Chlamydia diagnosis rate in England in 2012: an ecological study of local authorities

Objectives Local authorities (LAs) in England commission chlamydia screening as part of the National Chlamydia Screening Programme. It is recommended that LAs achieve a chlamydia diagnosis rate of ≥2300 cases per 100 000 population aged 15–24. We describe national patterns in attainment of the chlamydia diagnosis rate recommendation and possible implications of using it to measure LA-level performance. Methods We used publicly available data sets from England (2012) to explore the association between LAs attaining the recommended chlamydia diagnosis rate and population size, socioeconomic deprivation, test setting and sex. Results We used data from 1 197 121 recorded chlamydia tests in females and 564 117 in males. The chlamydia diagnosis rate recommendation was achieved by 22% (72/324) of LAs overall (43% female population; 8% male population). LAs in the highest deprivation quintile were more likely to reach the recommendation than those in the least-deprived quintile for both sexes (women: unadjusted prevalence ratio (UPR) 7.43, 95% CI 3.65 to 15.11; men: UPR 7.00, 95% CI 1.66 to 29.58). The proportion of tests performed in genitourinary medicine clinics was negatively associated with attainment of the recommended diagnosis rate (UPR 0.95, 0.93 to 0.97). Conclusions Chlamydia diagnosis rate recommendations that reflect local area deprivation (as a proxy for disease burden) may be more appropriate than a single national target if the aim is to reduce health inequalities nationally. We suggest LAs monitor their chlamydia diagnosis rate, test coverage and test positivity across a range of measures (including setting and sex) and pre/post changes to commissioned services. Critical evaluation of performance against the recommendation should be reflected in local commissioning decisions

Electrodeposition of lead-tin alloy from fluoborate solution-a voltammetric study

Lead-tin alloy deposition is done commercially from fluoborate bath. Though the practical aspects of addition agents for producing quality deposits are widely reported, the basic aspects on influence of these addition agents on alloy deposition are important. The techniques of cyclic and linear stripping voltammetry on a copper electrode in a fluoborate solution, with and without addition agents, have been employed to throw light on the basic aspects, with the aim of understanding, optimizing and controlling lead-tin alloy depositio

Metal-only Lewis pairs between group 10 metals and Tl(I) or Ag(I): insights into the electronic consequences of Z-type ligand binding†

Complexes bearing electron rich transition metal centers, especially those displaying coordinative unsaturation, are well-suited to form reverse-dative σ-interactions with Lewis acids. Herein we demonstrate the generality of zerovalent, group 10 m-terphenyl isocyanide complexes to form reverse-dative σ-interactions to Tl(I) and Ag(I) centers. Structural and spectroscopic investigations of these metal-only Lewis pairs (MOLPs) has allowed insight into the electronic consequences of Lewis-acid ligation within the primary coordination sphere of a transition metal center. Treatment of the bis-isocyanide complex, Pt(CNArDipp2)2 (ArDipp2 = 2,6-(2,6-(i-Pr)2C6H3)2C6H3) with TlOTf (OTf = [O3SCF3]−) yields the Pt/Tl MOLP [TlPt(CNArDipp2)2]OTf (1). 1H NMR and IR spectroscopic studies on 1, and its Pd congener [TlPd(CNArDipp2)2]OTf (2), demonstrate that the M → Tl interaction is labile in solution. However, treatment of complexes 1 and 2 with Na[BArF4] (ArF = 3,5-(CF3)2C6H3) produces [TlPt(CNArDipp2)2]BArF4 (3) and [TlPd(CNArDipp2)2]BArF4 (4), in which Tl(I) binding is shown to be static by IR spectroscopy and, in the case of 3, 195Pt NMR spectroscopy as well. This result provides strong evidence that the M → Tl linkages can be attributed primarily to σ-donation from the group 10 metal to Tl, as loss of ionic stabilization of Tl by the triflate anion is compensated for by increasing the degree of M → Tl σ-donation. In addition, X-ray Absorption Near-Edge Spectroscopy (XANES) on the Pd/Tl and Ni/Tl MOLPs, [TlPd(CNArDipp2)2]OTf (2) and [TlNi(CNArMes2)3]OTf, respectively, is used to illustrate that the formation of a reverse-dative σ-interaction with Tl(I) does not alter the spectroscopic oxidation state of the group 10 metal. Also reported is the ability of M(CNArDipp2)2 (M = Pt, Pd) to form MOLPs with Ag(I), yielding the complexes [AgM(CNArDipp2)2]OTf (5, M = Pt; 6, M = Pd). As was determined for the Tl-containing MOLPs 1–4, it is shown that the spectroscopic oxidation states of the group 10 metal in 5 and 6 are essentially unchanged compared to the zerovalent precursors M(CNArDipp2)2. However, in the case of 5 and 6, the formation of a dative M → Ag σ-bonding interaction facilitates the binding of Lewis bases to the group 10 metal trans to Ag, illustrating the potential of acceptor fragments to open up new coordination sites on transition metal complexes without formal, two-electron oxidation

Microstructure, Precipitation and Micro-segregation in Inconel 825 Weldments: A Comparative study between GTAW and EBW

Inconel 825 is a Ni-Fe-Cr alloy which is widely used in engineering due to its exceptional corrosion resistance and high-temperature strength. Welding (joining) of Inconel 825 has attracted strong research attention over the past few years. In this work, the effects of heat input leading to precipitation and micro segregation of Inconel 825 weldments were examined in light of comparing them while using two popular welding techniques namely, Gas tungsten arc welding (GTAW) and Electron beam welding (EBW). It was discovered that excessive heat input during GTAW can lead to root cracking and solidification cracking; while EBW demonstrated better control over undercut and maintains consistent weld quality even for higher heat inputs. Both GTAW and EBW samples exhibit dendritic grain morphologies with distinctive grain boundaries. Precipitates, such as Al4C3 and TiN were observed in both processes, contributing to improved mechanical properties. While GTAW weldments show some degree of segregation for Mo, Cu, Ti, and Al, EBW weldments demonstrate negligible segregation for major alloying elements but micro-segregation of Ti and Al. In general, the mechanical properties of EBW weldments was better as the average hardness, tensile strength, and ductility was much better compared to the GTAW weldments. This can be attributed to lower heat input, faster cooling rates, and a reduced rate of elemental segregation during EBW. Finally, the fractographic analysis revealed the presence of voids and micro-voids, indicating a ductile mode of failure for both GTAW and EBW samples. These findings offer invaluable insights for selecting the appropriate environment and welding method to join Inconel 825 for critical safety applications

Isolation and characterization of glycosaminoglycans from brain of children with protein-calorie malnutrition

The uronic acid containing glycosaminoglycans (GAGs) were isolated from the brains of 1-year-old and 4-year-old kwashiorkor children and characterised by constituent analyses. A marked reduction is the total GAG concentration of brain was noticed in both cases of kwashiorkor. In the 1-year-old kwashiorkor brain, hyaluronic acid is the most predominant GAG (73.5 per cent) whereas heparan sulphate, chondroitin sulphates and low sulphated chondroitin sulphate constituted less than 10 per cent. In the 4-year-old kwashiorkor brain, the proportion of hyaluronic acid was 27.5 per cent, low sulphated chondroitin sulphate 31.2 per cent, chondroitin sulphates 28.3 per cent and heparan sulphate 10 per cent. This marked reduction in the concentration as well as qualitative changes in GAG in protein-calorie malnutrition as compared to the normal is discussed in relation to brain function

Nearly Optimal Private Convolution

We study computing the convolution of a private input $x$ with a public input $h$, while satisfying the guarantees of $(\epsilon, \delta)$-differential privacy. Convolution is a fundamental operation, intimately related to Fourier Transforms. In our setting, the private input may represent a time series of sensitive events or a histogram of a database of confidential personal information. Convolution then captures important primitives including linear filtering, which is an essential tool in time series analysis, and aggregation queries on projections of the data. We give a nearly optimal algorithm for computing convolutions while satisfying $(\epsilon, \delta)$-differential privacy. Surprisingly, we follow the simple strategy of adding independent Laplacian noise to each Fourier coefficient and bounding the privacy loss using the composition theorem of Dwork, Rothblum, and Vadhan. We derive a closed form expression for the optimal noise to add to each Fourier coefficient using convex programming duality. Our algorithm is very efficient -- it is essentially no more computationally expensive than a Fast Fourier Transform. To prove near optimality, we use the recent discrepancy lowerbounds of Muthukrishnan and Nikolov and derive a spectral lower bound using a characterization of discrepancy in terms of determinants

The Kepler Pixel Response Function

Kepler seeks to detect sequences of transits of Earth-size exoplanets orbiting Solar-like stars. Such transit signals are on the order of 100 ppm. The high photometric precision demanded by Kepler requires detailed knowledge of how the Kepler pixels respond to starlight during a nominal observation. This information is provided by the Kepler pixel response function (PRF), defined as the composite of Kepler's optical point spread function, integrated spacecraft pointing jitter during a nominal cadence and other systematic effects. To provide sub-pixel resolution, the PRF is represented as a piecewise-continuous polynomial on a sub-pixel mesh. This continuous representation allows the prediction of a star's flux value on any pixel given the star's pixel position. The advantages and difficulties of this polynomial representation are discussed, including characterization of spatial variation in the PRF and the smoothing of discontinuities between sub-pixel polynomial patches. On-orbit super-resolution measurements of the PRF across the Kepler field of view are described. Two uses of the PRF are presented: the selection of pixels for each star that maximizes the photometric signal to noise ratio for that star, and PRF-fitted centroids which provide robust and accurate stellar positions on the CCD, primarily used for attitude and plate scale tracking. Good knowledge of the PRF has been a critical component for the successful collection of high-precision photometry by Kepler.Comment: 10 pages, 5 figures, accepted by ApJ Letters. Version accepted for publication