A Predictive Model for Mining Opinions of an Educational Database Using Neural Networks

Assessing the performance of an educational institute is a prime concern in an educational scenario. Educational Data Mining (EDM) considers several tasks originated from an educational context. One of the tasks identified is providing feedback for supporting instructors, administrators, teachers, course authors in decision making and thereby enable them to take appropriate remedial action. In this research, we have developed a prototype Neural Network Model which is trained to predict the performance of an educational institution. A Multilayer Perceptron Neural Network (MLP) model had been developed for this proposed research. The network is trained by back propagation algorithm. Data was obtained from a well-defined questionnaire consisting of 14 questions in the domains namely Academic Schedule, International Exposure, Jobs and Internship, Quality of the college, and Life at Campus. The results of these questions have been taken as inputs and performance of the institute has been considered as the output. To, validate the results generated by the network, statistical techniques have been used for the purpose. In this proposed research performance of an educational institution has been predicted. The results generated by the Neural Network and the statistical techniques have been compared in this research and it is observed that, both the methods have generated accurate results. The results have been considered based on the Normalized System Error (NSE) values of the network. A prototype Neural Network model has been developed to assess the performance of an educational institution

Change in Negative Affective Bias following a Single Ketamine Treatment for Treatment-Resistant Depression

Ketamine has recently emerged as a highly effective new treatment for people with treatment-resistant depression with rapid antidepressant effects. However, these effects are often short lasting, and the potential cognitive mechanisms underlying the therapeutic effects, such as effects on emotional processing bias, remain poorly understood. In the present study, we explored potential changes in emotional and cognitive processing following a single treatment of subcutaneous ketamine in a randomised double-blind controlled study with an active control. Participants with treatment-resistant major depressive disorder (MDD) were recruited from a single site from the Ketamine for Adult Depression Study (KADS Trial) and were randomly assigned to receive racemic ketamine hydrochloride (n=10) or midazolam hydrochloride (n=11) in a 1: 1 ratio. A healthy control sample (n=23) was recruited to attend a single experimental session without any treatment. All MDD participants completed mood ratings and cognitive assessments prior to and one day after a single randomised treatment. The results showed no significant differences in performance changes after treatment across the majority of emotion-related (i.e., Emotional Stroop Task, Affective Go/No-Go Task) and cognitive (Ruff 2 and 7 Selective Attention Test, Controlled Word Association Test) outcome measures. Participants who received ketamine showed a significant improvement in a negative processing bias test (i.e., The Scrambled Sentence Task; Cohen's d=.67, p=.016), which was not significantly associated with improvement in psychological symptoms (r=-.662, p=.074). The results from this exploratory study suggest that a single ketamine treatment may modulate negative affective bias. Limitations to this study included the small sample size and lack of follow-up. Future larger trials are required to confirm this finding

The Correlation between X-ray spectral slope and FeKalpha line energy in radio-quiet active galactic nuclei

A significant correlation between FeKalpha line energy and X-ray spectral slope has been discovered among radio-quiet active galactic nuclei. The ionization stage of the bulk of the FeKalpha emitting material is not the same in all active galactic nuclei and is related to the shape of the X-ray continua. Active galactic nuclei with a steep X-ray spectrum tend to have a fluorescence FeKalpha line from highly ionized material. In the narrow-line Seyfert 1 galaxies with steeper X-ray spectrum (Gamma_X > 2.1), the FeKalpha line originates from highly ionized material. In the Seyfert 1 galaxies and quasars with flatter X-ray spectrum (Gamma_X < 2.1), bulk of the FeKalpha emission arises from near neutral or weakly ionized material. The correlation is an important observational characteristic related to the accretion process in radio quiet active galactic nuclei and is driven by a fundamental physical parameter which is likely to be the accretion rate relative to the Eddington rate.Comment: 4 pages, To apear in ApJ Letter

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. CEACAM1 possesses adhesive and signaling properties mediated by its intrinsic immunorecep-tor tyrosine-based inhibitory motifs that recruit SHP-1 protein-tyrosine phosphatase. In this study, we demonstrate that CEACAM1 is expressed on the surface and in intracellular pools of platelets. In addition, CEACAM1 serves to negatively regulate signaling of platelets by collagen through the glycoprotein VI (GPVI)/Fc receptor (FcR)-?-chain. ceacam1 -/- platelets displayed enhanced type I collagen and GPVI-selective ligand, collagen-related peptide (CRP), CRP-mediated platelet aggregation, enhanced platelet adhesion on type I collagen, and elevated CRP-mediated alpha and dense granule secretion. Platelets derived from ceacam1-/- mice form larger thrombi when perfused over a collagen matrix under arterial flow compared with wild-type mice. Furthermore, using intravital microscopy to ferric chloride-injured mesenteric arterioles, we show that thrombi formed in vivo in ceacam1-/- mice were larger and were more stable than those in wild-type mice. GPVI depletion using monoclonal antibody JAQ1 treatment of ceacam1-/- mice showed a reversal in the more stable thrombus growth phenotype. ceacam1-/- mice were more susceptible to type I collagen-induced pulmonary thromboembolism than wild-type mice. Thus, CEACAM1 acts as a negative regulator of platelet-collagen interactions and of thrombus growth involving the collagen GPVI receptor in vitro and in vivo

Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease

Chronic kidney disease (CKD) is associated with accelerated cardiovascular disease and heart failure. Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease. The association of a cardiac functional difference in non-dialysis CKD patients with no known previous heart failure, and eNOS gene variant is investigated. Methods 140 non-dialysis CKD patients, who had cardiac magnetic resonance (CMR) imaging and tissue doppler echocardiography as part of two clinical trials, were genotyped for eNOS Glu298Asp SNP retrospectively. Results The median estimated glomerular filtration rate (eGFR) was 50mls/min and left ventricular ejection fraction (LVEF) was 74 with no overt diastolic dysfunction in this cohort. There were significant differences in LVEF across eNOS genotypes with GG genotype being associated with a worse LVEF compared to other genotypes (LVEF: GG 71, TG 76, TT 73, p = 0.006). After multivariate analysis, (adjusting for age, eGFR, baseline mean arterial pressure, contemporary CMR heart rate, total cholesterol, high sensitive C-reactive protein, body mass index and gender) GG genotype was associated with a worse LVEF, and increased LV end-diastolic and systolic index (p = 0.004, 0.049 and 0.009 respectively). Conclusions eNOS Glu298Asp rs1799983 polymorphism in CKD patients is associated with relevant sub-clinical cardiac remodelling as detected by CMR. This gene variant may therefore represent an important genetic biomarker, and possibly highlight pathways for intervention, in these patients who are at particular risk of worsening cardiac disease as their renal dysfunction progresses. © 2015 Chand et al

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.

Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdrawal resulted in a 5- to 10-fold protective effect with chemotherapy treatment. PDAC xenografts were less sensitive to gemcitabine in hypoglycemic mice compared with hyperglycemic mice. Consistent with this observation, patients receiving adjuvant gemcitabine (n = 107) with elevated serum glucose levels (HgbA1C \u3e 6.5%) exhibited improved survival. We identified enhanced antioxidant defense as a driver of chemoresistance in this setting. ROS levels were doubled in vitro by either nutrient withdrawal or gemcitabine treatment, but depriving PDAC cells of nutrients before gemcitabine treatment attenuated this effect. Mechanistic investigations based on RNAi or CRISPR approaches implicated the RNA binding protein HuR in preserving survival under nutrient withdrawal, with or without gemcitabine. Notably, RNA deep sequencing and functional analyses in HuR-deficient PDAC cell lines identified isocitrate dehydrogenase 1 (IDH1) as the sole antioxidant enzyme under HuR regulation. HuR-deficient PDAC cells lacked the ability to engraft successfully in immunocompromised mice, but IDH1 overexpression in these cells was sufficient to fully restore chemoresistance under low nutrient conditions. Overall, our findings highlight the HuR–IDH1 regulatory axis as a critical, actionable therapeutic target in pancreatic cancer

The importance of low-deformation vorticity in tropical cyclone formation

Studies of tropical cyclone (TC) formation from tropical waves have shown that TC formation requires a wave-relative quasi-closed circulation: the "marsupial pouch" concept. This results in a layerwise nearly contained region of atmosphere in which the modification of moisture, temperature and vorticity profiles by convective and boundary layer processes occurs undisturbed. The pouch concept is further developed in this paper. TCs develop near the centre of the pouch where the flow is in near solid body rotation. A reference-frame independent parameter is introduced that effectively measures the level of solid-body rotation in the lower troposphere. The parameter is the product of a normalized Okubo-Weiss parameter and absolute vorticity (OWZ). &lt;br&gt;&lt;br&gt; Using 20 yr of ERA-interim reanalysis data and the IBTrACS global TC database, it is shown 95% of TCs including, but not limited to, those forming in tropical waves are associated with enhanced levels of OWZ on both the 850 and 500 hPa pressure levels at the time of TC declaration, while 90% show enhanced OWZ for at least 24 h prior to declaration. This result prompts the question of whether the pouch concept extends beyond wave-type formation to all TC formations world-wide. &lt;br&gt;&lt;br&gt; Combining the OWZ with a low vertical shear requirement and lower troposphere relative humidity thresholds, an imminent genesis parameter is defined. The parameter includes only relatively large-scale fluid properties that are resolved by coarse grid model data (&gt;150 km), which means it can be used as a TC detector for climate model applications. It is also useful as a cyclogenesis diagnostic in higher resolution models such as real-time global forecast models