Ionization cross sections for low energy electron transport

Two models for the calculation of ionization cross sections by electron impact on atoms, the Binary-Encouter-Bethe and the Deutsch-Maerk models, have been implemented; they are intended to extend and improve Geant4 simulation capabilities in the energy range below 1 keV. The physics features of the implementation of the models are described, and their differences with respect to the original formulations are discussed. Results of the verification with respect to the original theoretical sources and of extensive validation with respect to experimental data are reported. The validation process also concerns the ionization cross sections included in the Evaluated Electron Data Library used by Geant4 for low energy electron transport. Among the three cross section options, the Deutsch-Maerk model is identified as the most accurate at reproducing experimental data over the energy range subject to test.Comment: To be published in IEEE Trans. Nucl. Sci., Dec. 201

Physics data management tools: computational evolutions and benchmarks

The development of a package for the management of physics data is described: its design, implementation and computational benchmarks. This package improves the data management tools originally developed for Geant4 physics models based on the EADL, EEDL and EPDL97 data libraries. The implementation exploits recent evolutions of the C++ libraries appearing in the C++0x draft, which are intended for inclusion in the next C++ ISO Standard. The new tools improve the computational performance of physics data management.Comment: 6 pages, to appear in proceedings of the Joint International Conference on Supercomputing in Nuclear Applications and Monte Carlo 2010 (SNA + MC2010

Understanding the Balanced Effects of Belief and Feeling on Information Systems Continuance

There are innumerable studies on technology adoption as well as continuance of usage. A review of previous research shows that cognitive factors are considered prominently in information technology adoption and continuance while the affective feelings of users are not. Although attitude and user satisfaction are common factors considered in information systems research, these factors only involve partial aspects of feelings. Researchers in the marketing areas, as well as the psychology area, begin to note the importance of feelings in understanding and predicting human and customer behavior. In many modern applications, such as mobile Internet services, user feelings are expected to be important, since users are not just technology users but also service consumers. Drawing upon the support of consumer research, social psychology, and computer science, this study proposes a balanced belief–feeling model of IS continuance. In the process of developing this model, the concepts of attitude, belief, and feelings are further articulated, defined, and distinguished. The balanced model is tested in a survey of mobile Internet users. The results established the validity of the model. A comparison with the IS continuance model shows that the new model can explain significantly more variance in continuance intention, taking into account that the new model has more factors. We offer theoretical reasoning for the balanced effects of belief and feeling on IS continuance and discuss the theoretical and practical implications of this study

Spreadsheet Error Correction Using an Activity Framework and a Cognitive Fit Perspective

Errors in a spreadsheet constitute a serious reason for concern among organizations as well as academics. There are ongoing efforts toward finding ways to reduce errors, designing and developing visualization tools to support error correction activities being one of them. In this paper, we propose a framework for classifying activities associated with spreadsheet error correction. The purpose of this framework is to help in understanding the activities that are important for correcting different types of spreadsheet errors and how different visualization tools can help in error correction by effectively supporting these activities. An experiment is designed to test the effectiveness of a visualization tool that supports one of the most important activities from the framework – chaining activity. Two groups of subjects, with and without the visualization tool, are required to correct two types of errors. Our hypotheses are derived based on the notion of cognitive fit between problem representation and task, and the results of the experiment support most of the hypotheses. Thus, this study demonstrates the usefulness of the activity-based framework for spreadsheet error correction, and also provides guidelines for designing and developing tools for spreadsheet audit. It also provides empirical evidence to the cognitive fit theory by showing that performance is significantly better when visual support tools result in a match between problem representation and the task in hand, as in the case of correcting link errors with the tool used in this study. Theoretical and practical implications of the findings are discussed

Association of serum adipocytokine levels with cardiac autonomic neuropathy in type 2 diabetic patients

<p>Abstract</p> <p>Background</p> <p>Cardiac autonomic neuropathy (CAN) is a common complication of diabetes associated with poor prognosis. In addition, the autonomic imbalance is associated with cardiovascular disease (CVD) in diabetes. It is thought that adipocytokines contribute to the increased risk of vascular complications in patients with type 2 diabetes mellitus (T2DM). However, literature data on the association between CAN with adipocytokines such as leptin, tumor necrosis factor-alpha (TNF-alpha), adiponectin in subjects with T2DM is limited.</p> <p>Therefore, in the present study, we examined the relationship between fasting serum leptin, TNF- alpha and adiponectin and CAN in Korean T2DM patients.</p> <p>Methods</p> <p>A total of 142 T2DM patients (94 males, 48 females) were recruited. CAN was assessed by the five tests according to the Ewing's protocol and the time and frequency domain of the heart rate variability (HRV) was evaluated. Serum TNF-alpha and adiponectin levels were measured using enzyme-linked immunosorbent assay and serum leptin levels were measured using radioimmunoassay.</p> <p>Results</p> <p>Although, the mean levels of leptin, TNF-alpha and adiponectin were not significantly different between the groups with and without CAN, the levels of leptin and adiponectin had a tendency to increase as the score of CAN increased (p = 0.05, p = 0.036). Serum leptin levels demonstrated a negative correlation with low frequency (LF) in the upright position (p = 0.037). Regarding TNF-alpha, a significant negative correlation was observed with SDNN and RMSSD in the upright position (p = 0.023, p = 0.019). Adiponectin levels were not related to any HRV parameters. Multivariate logistic regression analysis demonstrated that the odds of CAN increased with a longer duration of diabetes (1.25, [1.07-1.47]) and higher homeostatic model of assessment-insulin resistance (HOMA-IR) (5.47, [1.8-16.5]). The relative risks for the presence of CAN were 14.1 and 51.6 for the adiponectin 2^nd, 3^rdtertiles when compared with first tertile (p-value for trend = 0.022).</p> <p>Conclusions</p> <p>In the present study, the higher serum adiponectin levels and HOMA-IR were associated with an increased risk for the presence of CAN. Also, the CAN score correlated with the serum adiponectin. Serum adipocytokines such as leptin and TNF-alpha were significantly correlated with parameters of HRV, representative markers of CAN. Future prospective studies with larger number of patients are required to establish a direct relationship between plasma adipocytokine concentrations and the development or severity of CAN.</p

One-pot Enzymatic Synthesis of Deoxy-thymidine-diphosphate (TDP)-2-deoxy-∝-d-glucose Using Phosphomannomutase

Production of deoxy-thymidine-diphosphate (TDP)-sugars as substrates of glycosyltransferases, has been one of main hurdles for combinatorial antibiotic biosynthesis, which combines sugar moiety with aglycon of various antibiotics. Here, we report the one-pot enzymatic synthesis of TDP-2-deoxy-glucose employing high efficient TMP kinase (TMK; E.C. 2.7.2.12), acetate kinase (ACK; E.C. 2.7.1.21), and TDP-glucose synthase (TGS; E.C. 2.7.7.24) with phosphomannomutase (PMM; E.C. 5.4.2.8). In this study, replacing phosphoglucomutase (PGM; E.C. 5.4.2) by PMM from Escherichia coli gave four times higher specific activity on 2-deoxy-6-phosphate glucose, suggesting that the activity on 2-deoxy-glucose-6-phosphate was mainly affected by PMM activity, not PGM activity. Using an in vitro system starting from TMP and 2-deoxy-glucose-6-phosphate glucose, TDP-2-deoxy-glucose (63% yield) was successfully synthesized. Considering low productivity of NDP-sugars from cheap starting materials, this paper showed how production of NDP-sugars could be enhanced by controlling mutase activity

Differential associations of central and brachial blood pressure with carotid atherosclerosis and microvascular complications in patients with type 2 diabetes

BACKGROUND: We examined the relationship between central blood pressure (BP), brachial BP with carotid atherosclerosis and microvascular complications in type 2 diabetes mellitus (T2DM). METHODS: We recruited 201 patients who were evaluated for central BP, brachial BP, carotid ultrasonography, brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI) and microvascular complications. Central BP were calculated using a radial automated tonometric system. RESULTS: Agreement between central BP and brachial BP was very strong (concordance correlation coefficient between central and brachial SBP = 0.889, between central and brachial PP = 0.816). Central pulse pressure (PP) was correlated with mean carotid intima-media thickness (CIMT), baPWV and ABI, whereas brachial PP was borderline significantly correlated with CIMT. The prevalence of nephropathy(DN) and retinopathy(DR) according to the brachial PP tertiles increased, the prevalences of microvascular complications were not different across central PP tertiles. In multivariate analysis, the relative risks (RRs) for the presence of DR were 1.2 and 4.6 for the brachial PP tertiles 2 and 3 when compared with the first tertile. Also, the RRs for the presence of DN were 1.02 and 3 for the brachial PP tertiles 2 and 3 when compared with the first tertile. CONCLUSIONS: Agreement of central BP and brachial BP was very strong. Nonetheless, this study showed that higher brachial PP levels are associated with increased probability for the presence of microvascular complications such as DR/DN. However, there are no associations with central SBP and central PP with microvascular complications. Central BP levels than brachial BP are correlated with surrogate marker of macrovascular complications

The Role of Visualization Tools in Spreadsheet Error Correction from a Cognitive Fit Perspective

Errors in spreadsheets pose a serious problem for organizations and academics. This has resulted in ongoing efforts to devise measures for reducing errors or efficient ways of correcting them. Visualization tools are often advertised as means for improving spreadsheet error correction performance. This study investigates the role of visualization tools in spreadsheet error correction. For this purpose, this study proposes a framework for classifying activities associated with spreadsheet error correction. The framework is to highlight the activities that are important for correcting different types of spreadsheet errors, and to show how different visualization tools can aid error correction by effectively supporting these activities. By identifying chaining as one of the most important activities from the framework, this study uses cognitive fit theory to examine the effects of a visualization tool that supports chaining on spreadsheet error correction performance. Experimental methodology is used to test the outcome of cognitive fit between the error correction task and the visualization tool. The results of the experiment highlight the importance of cognitive fit between the type of task and the visualization tool for attaining better performance. This study also provides guidelines for designing and developing tools for spreadsheet error correction