The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Harmony as a contested metaphor and conceptions of rightness (yi) in early Confucian ethics

Abstract not available

Sage nature and the logic of namelessness: reconstructing He Yan's explication of Dao

No abstract available

鍾會《老子注》與魏初才性之辯

Abstract not available

The Risk-Taking Propensity of Construction Workers—An Application of Quasi-Expert Interview

High accident rates have been a complicated and persistent problem in the Hong Kong construction industry. This situation has stimulated this investigation into factors that influence the risk-taking propensity of construction workers. However, interviewing workers who had a bad experience is problematic because changes in attitude and perception may occur as a result of such an experience. Using quasi-expert interviews can reduce this problem. The objective of this study was to identify factors that influence the risk-taking propensity of construction workers. Semi-structured interviews were conducted with 16 safety professionals all with accident inspection experience and six super-safe workers with no incident record for the past five years. Seven factors that affect the risk-taking propensity of construction workers were successfully identified. Each factor is thoughtfully discussed, and this study shows that quasi-expert interview is a pragmatic approach for deepening the understanding of risk-taking propensity among construction workers. Findings of this study will hopefully help and encourage further quantitative research on the risk-taking propensity of construction workers with different perspectives

Construction Worker Risk-Taking Behavior Model with Individual and Organizational Factors

Behavioral-based safety is an important application of behavioral science that can be used to address safety problems in the construction sector. An understanding of construction worker risk-taking behavior is deemed to be a crucial basis on which concerned authorities and construction companies can develop effective safety interventions to reduce construction accidents. However, no studies have been conducted to examine the effects of safety climate, work condition, attitude toward risk, cognitive bias, and risk perception on construction worker risk-taking behavior through a quantitative approach. Accordingly, this study aims to propose a research model that explains construction worker risk-taking behavior. A total of 188 valid datasets were obtained through a series of questionnaire surveys conducted in representative construction projects in Hong Kong. Confirmatory factor analysis with structural equation modeling was adopted to validate the hypothesized research model. Results show that attitudes toward risk and cognitive bias have a positive influence, whereas risk perception and work conditions have a negative influence on construction worker risk-taking behavior. In addition, safety climate was negatively correlated with construction worker risk-taking behavior. Practical recommendations for reducing construction worker risk-taking behavior are also discussed in this paper

Effect of Plasma Treatment on Native Defects and Photocatalytic Activities of Zinc Oxide Tetrapods

ZnO tetrapods, as a ZnO nanostructure with a low defect concentration, were subjected to plasma treatments using different gases to induce different types of defects in the samples and examine their effects on sample properties. Hydrogen and argon plasmas resulted in significant oxygen deficiencies, but no defect emission appeared. Oxygen plasma had only a minor effect on the sample composition, but it resulted in the appearance of defect emission and a significant overall reduction in luminescence intensity. On the other hand, the photocatalytic activity was significantly reduced in samples exhibiting oxygen deficiencies. It can thus be concluded that oxygen vacancies do not participate in the green emission of ZnO and also that their presence at the sample surface does not enhance the photocatalytic activity

Effect of ZnO Nanoparticle Properties on Dye-Sensitized Solar Cell Performance

We have investigated the effect of ZnO nanoparticle properties on the dye-sensitized solar cell performance. Nanoparticles with different sizes and optical properties were considered. We found that there is a complex relationship between native defects, dye adsorption, charge transport and solar cell performance. The presence of a high concentration of nonradiative defects was found to be detrimental to photovoltaic performance, whereas for radiative defects, samples displaying orange-red defect emission exhibited better performance compared to samples with green defect emission (when the samples had similar emission intensities). Detailed discussion of the nanoparticle properties and their relationship with dye adsorption, electron injection, electron lifetime, electron transport time, and solar cell performance is given