Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations

Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2 also associates with Mfn1, but the functional significance of such heterooligomeric complexes is unknown. Also unknown is why Mfn2 mutations in CMT2A lead to cell type–specific defects given the widespread expression of Mfn2. In this study, we show that homooligomeric complexes formed by many Mfn2 disease mutants are nonfunctional for mitochondrial fusion. However, wild-type Mfn1 complements mutant Mfn2 through the formation of heterooligomeric complexes, including complexes that form in trans between mitochondria. Wild-type Mfn2 cannot complement the disease alleles. Our results highlight the functional importance of Mfn1–Mfn2 heterooligomeric complexes and the close interplay between the two mitofusins in the control of mitochondrial fusion. Furthermore, they suggest that tissues with low Mfn1 expression are vulnerable in CMT2A and that methods to increase Mfn1 expression in the peripheral nervous system would benefit CMT2A patients

Fluctuations and universality in a catalysis model with long-range reactivity

The critical properties of the Ziff-Gulari-Barshad (ZGB) model with the addition of long-range reactivity [C.H. Chan and P.A. Rikvold, Phys. Rev. E 91, 012103 (2015)] are further investigated. The scaling behaviors of the order parameter, susceptibility, and correlation length provide addi- tional evidence that the universality class of the ZGB system changes from the two-dimensional Ising class to the mean-field class with the addition of even a weak long-range reactivity mechanism

Instability of three dimensional conformally dressed black hole

The three dimensional black hole solution of Einstein equations with negative cosmological constant coupled to a conformal scalar field is proved to be unstable against linear circularly symmetric perturbations.Comment: 5 pages, REVTe

Transformation media that rotate electromagnetic fields

We suggest a way to manipulate electromagnetic wave by introducing a rotation mapping of coordinates that can be realized by a specific transformation of permittivity and permeability of a shell surrounding an enclosed domain. Inside the enclosed domain, the information from outside will appear as if it comes from a different angle. Numerical simulations were performed to illustrate these properties.Comment: 5 pages, 3 figure

Electric field induced charge noise in doped silicon: ionization of phosphorus donors

We report low frequency charge noise measurement on silicon substrates with different phosphorus doping densities. The measurements are performed with aluminum single electron transistors (SETs) at millikelvin temperatures where the substrates are in the insulating regime. By measuring the SET Coulomb oscillations, we find a gate voltage dependent charge noise on the more heavily doped substrate. This charge noise, which is seen to have a 1/f spectrum, is attributed to the electric field induced tunneling of electrons from their phosphorus donor potentials.Comment: 4 page, 3 figure