55,414 research outputs found

    Microwave induced elastic deformation of a metallic thin film

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    The microwave induced elastic deformation of a metallic thin film is computed numerically and we found that the deformation can be significantly enhanced at resonance. We show that an analytical transmission line model can reproduce the numerical results almost quantitatively and at the same time reveal the underlying physics.Comment: 8 pages,3 figure

    Thermal Casimir force between nanostructured surfaces

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    We present detailed calculations for the Casimir force between a plane and a nanostructured surface at finite temperature in the framework of the scattering theory. We then study numerically the effect of finite temperature as a function of the grating parameters and the separation distance. We also infer non-trivial geometrical effects on the Casimir interaction via a comparison with the proximity force approximation. Finally, we compare our calculations with data from experiments performed with nanostructured surfaces

    Axiomatic Holonomy Maps and Generalized Yang-Mills Moduli Space

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    This article is a follow-up of ``Holonomy and Path Structures in General Relativity and Yang-Mills Theory" by Barrett, J. W. (Int.J.Theor.Phys., vol.30, No.9, 1991). Its main goal is to provide an alternative proof of this part of the reconstruction theorem which concerns the existence of a connection. A construction of connection 1-form is presented. The formula expressing the local coefficients of connection in terms of the holonomy map is obtained as an immediate consequence of that construction. Thus the derived formula coincides with that used in "On Loop Space Formulation of Gauge Theories" by Chan, H.-M., Scharbach, P. and Tsou S.T. (Ann.Phys., vol.167, 454-472, 1986). The reconstruction and representation theorems form a generalization of the fact that the pointed configuration space of the classical Yang-Mills theory is equivalent to the set of all holonomy maps. The point of this generalization is that there is a one-to-one correspondence not only between the holonomy maps and the orbits in the space of connections, but also between all maps from the loop space on MM to group GG fulfilling some axioms and all possible equivalence classes of P(M,G)P(M,G) bundles with connection, where the equivalence relation is defined by bundle isomorphism in a natural way.Comment: amslatex, 7 pages, no figure

    Poisson noise induced switching in driven micromechanical resonators

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    We study Poisson-noise induced switching between coexisting vibrational states in driven nonlinear micromechanical resonators. In contrast to Gaussian noise induced switching, the measured logarithm of the switching rate is proportional not to the reciprocal noise intensity, but to its logarithm, for fixed pulse area. We also find that the switching rate logarithm varies as a square root of the distance to the bifurcation point, instead of the conventional scaling with exponent 3/2.Comment: accepted by PR

    Treatment of Neuroblastoma with an Engineered “Obligate” Anaerobic Salmonella typhimurium Strain YB1

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    3-Body Dynamics in a (1+1) Dimensional Relativistic Self-Gravitating System

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    The results of our study of the motion of a three particle, self-gravitating system in general relativistic lineal gravity is presented for an arbitrary ratio of the particle masses. We derive a canonical expression for the Hamiltonian of the system and discuss the numerical solution of the resulting equations of motion. This solution is compared to the corresponding non-relativistic and post-Newtonian approximation solutions so that the dynamics of the fully relativistic system can be interpretted as a correction to the one-dimensional Newtonian self-gravitating system. We find that the structure of the phase space of each of these systems yields a large variety of interesting dynamics that can be divided into three distinct regions: annulus, pretzel, and chaotic; the first two being regions of quasi-periodicity while the latter is a region of chaos. By changing the relative masses of the three particles we find that the relative sizes of these three phase space regions changes and that this deformation can be interpreted physically in terms of the gravitational interactions of the particles. Furthermore, we find that many of the interesting characteristics found in the case where all of the particles share the same mass also appears in our more general study. We find that there are additional regions of chaos in the unequal mass system which are not present in the equal mass case. We compare these results to those found in similar systems.Comment: latex, 26 pages, 17 figures, high quality figures available upon request; typos and grammar correcte

    Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

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    Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere. We therefore investigated contractile and regulatory proteins in left ventricular tissue from 25 cats, 18 diagnosed with HCM, including a Ragdoll cat with a homozygous MYBPC3 R820W, and 7 non-HCM cats in comparison with human HCM (from septal myectomy) and donor heart tissue. Myofibrillar protein expression was normal except that we observed 20–44% MyBP-C haploinsufficiency in 5 of the HCM cats. Troponin extracted from 8 HCM and 5 non-HCM cat hearts was incorporated into thin filaments and studied by in vitro motility assay. All HCM cat hearts had a higher (2.06 ± 0.13 fold) Ca2+-sensitivity than non-HCM cats and, in all the HCM cats, Ca2+-sensitivity was not modulated by troponin I phosphorylation. We were able to restore modulation of Ca2+-sensitivity by replacing troponin T with wild-type protein or by adding 100 μM Epigallocatechin 3-gallate (EGCG). These fundamental regulatory characteristics closely mimic those seen in human HCM indicating a common molecular mechanism that is independent of the causative mutation. Thus, the HCM cat is a potentially useful large animal model
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