Ambulatory intraocular pressure fluctuation recording with a novel wireless smart silicone contact lens sensor

The Conference program's website is located at http://apacrs2014.org/free_papers.htmlSession - FP1: General: no. FP1-03INTRODUCTION: Monitoring of treatment response in the management of glaucomatous optic neuropathy relies on single intraocular pressure (IOP) measurements during regular clinic hours at regular intervals. However IOP is a dynamic parameter with circadian rhythms as well as posture and exercise related fluctuations. The introduction of continuous 24 hour IOP monitoring technology has created a paradigm shift in glaucoma management. Our wireless smart contact lens sensor was previously validated in-vivo and ex-vivo in animal models. Here we describe the performance of the sensor in ...postprin

A Systematic Review of Side Effects of Nucleoside and Nucleotide Drugs Used for Treatment of Chronic Hepatitis B

Although nucleosides and nucleotides have a good safety record for the treatment of hepatitis B, there have been no systematic reviews on this topic. We searched Medline to include studies of the oral antiviral agents for hepatitis B and adverse events, with at least 48 weeks of follow-up from the initiation of treatment with the drug. Important toxicities include nephrotoxicity, myopathy, and resistance. It is often difficult to ascertain whether an adverse effect is from the study drug or the natural progression of the disease. Further safety data are needed for the newer agents and for all agents with regard to patients with decompensated liver disease, renal dysfunction, the elderly, children, and pregnant women

Factors affecting patient-reported outcomes after red blood cell transfusion in medical patients

BACKGROUND Physical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study. STUDY DESIGN AND METHODS The study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center. The primary outcome was the change in HRQoL scores on Days 1 and 7 posttransfusion from baseline values on the day of transfusion (Day 0). Multiple linear regression analysis was performed to study the effect of transfusion strategy and other factors on PRO. RESULTS The analysis included 99 general medical patients. The median (interquartile range) pretransfusion hemoglobin level was 72 (66-78) g/L. Two or more units of RBCs were prescribed to 45 patients (45%) on Day 0. Functional Assessment of Cancer Therapy-Anemia Subscale improved significantly on Days 1 and 7 by effect sizes of 0.41 and 0.38, respectively (p < 0.001). Regression analysis showed that lower baseline HRQoL scores were associated with better PRO on both Day 1 and Day 7 (p < 0.001). Transfusion trigger and number of RBC units transfused did not affect the change in HRQoL. CONCLUSION Worse pretransfusion HRQoL is a predictor of improvement in PRO after blood transfusion. There is no evidence that a restrictive transfusion or single-unit policy jeopardizes PRO

Ambulatory intraocular pressure fluctuation recording with a novel wireless smart silicone contact lens sensor

S227 Glaucoma - Free Paper Session: Clinical Sciences 4The Conference program's website is located at http://www.apgc-isohk-2014.org/2014/congress/register/PDS_program_schedule.php?session_id=67Introduction: Monitoring of treatment response in the anagement of glaucomatous optic neuropathy relies on single intraocular pressure (IOP) measurements during regular clinic hours at regular intervals. However IOP is a dynamic parameter with circadian rhythms as well as posture and exercise related fluctuations. The introduction of continuous 24 hour IOP monitoring technology has created a paradigm shift in glaucoma management. Our wireless smart contact lens sensor was previously validated in-vivo and ex-vivo in animal models. Here we describe the performance of the sensor in ambulatory human subjects. Methodology: The performance of the sensor is tested in healthy human subjects over 24 hours while assuming normal activities to document individualized circadian rhythms. The sensor is then used to document specific postural changes and moderate aerobic exercise. The order of serial postural changes was as follows: sitting ⇒ supine 10 mins ⇒supine 30 mins ⇒ sitting. For moderate aerobic exercise, IOP fluctuation was tested during 20-minute moderate submaximal exercise (60-80 Watts) on a bicycle ergometer. Results: 5 healthy subjects were recruited for preliminary testing. Intraocular pressure fluctuation profiles firstly over 24 hours and secondly during specific ostural changes and moderate aerobic exercise are documented. Highly individual and repeatable profiles were obtained. Conclusion: This contact lens sensor can detect IOP fluctuations related to circadian rhythms, postural changes and exercise. It has potential to be used in 24 hour IOP monitoring in glaucoma management