Accounting for the association of family conflict and heavy alcohol use among adolescent girls: the role of depressed mood

Objective: Heavy alcohol use increases dramatically at age 14, and there is emerging cross-sectional evidence that when girls experience family conflict at younger ages (11-13 years) the risk of alcohol use and misuse is high. This study evaluated the role of family conflict and subsequent depressed mood in predicting heavy alcohol use among adolescent girls. Method: This was a three-wave longitudinal study with annual assessments (modal ages 12, 13, and 14 years). The participants (N = 886, 57% female) were from 12 metropolitan schools in Victoria, Australia, and participants completed questionnaires during school class time. The key measures were based on the Communities That Care Youth Survey and included family conflict (Wave 1), depressed mood (Wave 2), and heavy alcohol use (Wave 3). Control variables included school commitment, number of peers who consumed alcohol, whether parents were living together, and ethnic background. Results: With all controls in the model, depressed mood at Wave 2 was predicted by family conflict at Wave 1. The interaction of family conflict with gender was significant, with girls showing a stronger association of family conflict and depressed mood. Depressed mood at Wave 2 predicted heavy alcohol use at Wave 3. Conclusions: Girls may be especially vulnerable to family conflict, and subsequent depressed mood increases the risk of heavy alcohol use. The results support the need for gender-sensitive family-oriented prevention programs delivered in late childhood and early adolescence. (J. Stud. Alcohol Drugs, 74, 396-405, 2013

The relationship between psychological distress and adolescent polydrug use

Polydrug use is relatively common among adolescents. Psychological distress is associated with the use of specific drugs, and may be uniquely associated with polydrug use. The purpose of this study was to test the association of psychological distress with polydrug use using a large adolescent sample. The sample consisted of 10,273 students aged 12-17 years from the State of Victoria, Australia. Participants completed frequency measures of tobacco, alcohol, cannabis, inhalant, and other drug use in the past 30 days, and psychological distress. Control variables included age, gender, family socioeconomic status, school suspensions, academic failure, cultural background, and peer drug use. Drug-use classes were derived using latent-class analysis, then the association of psychological distress and controls with drug-use classes was modeled using multinomial ordinal regression. There were 3 distinct classes of drug use: no drug use (47.7%), mainly alcohol use (44.1%), and polydrug use (8.2%). Independent of all controls, psychological distress was higher in polydrug users and alcohol users, relative to nondrug users, and polydrug users reported more psychological distress than alcohol users. Psychological distress was most characteristic of polydrug users, and targeted prevention outcomes may be enhanced by a collateral focus on polydrug use and depression and/or anxiety

A review of segmentation and deformable registration methods applied to adaptive cervical cancer radiation therapy treatment planning

Objective: Manual contouring and registration for radiotherapy treatment planning and online adaptation for cervical cancer radiation therapy in computed tomography (CT) and magnetic resonance images (MRI) are often necessary. However manual intervention is time consuming and may suffer from inter or intra-rater variability. In recent years a number of computer-guided automatic or semi-automatic segmentation and registration methods have been proposed. Segmentation and registration in CT and MRI for this purpose is a challenging task due to soft tissue deformation, inter-patient shape and appearance variation and anatomical changes over the course of treatment. The objective of this work is to provide a state-of-the-art review of computer-aided methods developed for adaptive treatment planning and radiation therapy planning for cervical cancer radiation therapy. Methods: Segmentation and registration methods published with the goal of cervical cancer treatment planning and adaptation have been identified from the literature (PubMed and Google Scholar). A comprehensive description of each method is provided. Similarities and differences of these methods are highlighted and the strengths and weaknesses of these methods are discussed. A discussion about choice of an appropriate method for a given modality is provided. Results: In the reviewed papers a Dice similarity coefficient of around 0.85 along with mean absolute surface distance of 2-4. mm for the clinically treated volume were reported for transfer of contours from planning day to the treatment day. Conclusions: Most segmentation and non-rigid registration methods have been primarily designed for adaptive re-planning for the transfer of contours from planning day to the treatment day. The use of shape priors significantly improved segmentation and registration accuracy compared to other models

Proximate causes and possible adaptive functions of mast seeding and barren flower shows in spinifex grasses (Triodia spp.) in arid regions of Australia

Mast seeding, the intermittent production of large synchronised seed crops among plant populations, is a phenomenon that occurs at exceptionally long intervals in spinifex grasses (Triodia spp.) from arid regions of Australia. This is despite the reliance of these fire-sensitive plants on seeds for post-fire regeneration, and that spinifex grasslands rate among Australia's most flammable ecosystems. The proximate causes and possible adaptive functions of masting in seven species of spinifex from arid regions within the 350-mm rainfall isohyet were investigated. Specifically, the seed set percentages of 79 specimens collected between 1947 and 2012 were related to the following environmental covariates: antecedent rainfall over 6, 12 and 36 months, relative humidity, and the number of days above 40 degrees C and below 0 degrees C during anthesis. Given the potential importance of seeding events for post-fire regeneration, it was also investigated whether masting in Triodia could represent a fire-related form of environmentally predictive masting, by testing whether high-yield years corresponded to years of increased fire occurrence. Examination of the dataset showed that 43% of specimens contained completely aborted inflorescences (0% seed fill), while seed set ranged from 2 to 69% in the remaining specimens. High levels of insect activity were also found, with 42% of specimens showing evidence of insect occupation. Statistical analyses showed that the main environmental driver of seed set was high precipitation over the previous 12 months, and that high-yield years were strongly related to years of increased fire likelihood. The number of days over 40 degrees Cwas a weakly significant driver of yield, while the remaining covariates were not significant. It is hypothesised that intermittent reproduction by Triodia is a fire-related form of environmentally predictive masting, which maximises chances of post-fire regeneration by satiating seed predators during flammable periods (i.e. after heavy rain years). Furthermore, it is suggested that non-viable flower crops after initial low rainfalls may have an adaptive function, by diluting pre-dispersal seed predator densities with 'decoy' ovules that do not mature and lead to the starvation of developing larvae