Nielsen-Olesen vortex in varying-alpha theories

We consider soliton solutions to Bekenstein's theory, for which the fine structure constant $\alpha=e^2/(4\pi\hbar c)$ is allowed to vary due to the presence of a dielectric field pervading the vacuum. More specifically we investigate the effects of a varying $\alpha$ upon a complex scalar field with a U(1) electromagnetic gauge symmetry subject to spontaneous symmetry breaking. We find vortex solutions to this theory, similar to the Nielsen-Olesen vortex. Near the vortex core the electric charge is typically much larger than far away from the string, lending these strings a superconducting flavour. In general the dielectric field coats the usual local string with a global string envelope. We discuss the cosmological implications of networks of such strings, with particular emphasis on their ability to generate inhomogeneous recombination scenarios. We also consider the possibility of the dielectric being a charged free field. Even though the vacuum of such a field is trivial, we find that the dielectric arranges itself in the shape of a local string, with a quantized magnetic flux at the core -- presumably borrowing these topological features from the underlying Nielsen-Olesen vortex.Comment: 7 pages, 1 figur

WMAP Data and Recent Developments in Supersymmetric Dark Matter

A brief review is given of the recent developments in the analyses of supersymmetric dark matter. Chief among these is the very accurate determination of the amount of cold dark matter in the universe from analyses using WMAP data. The implications of this data for the mSUGRA parameter space are analyzed. It is shown that the data admits solutions on the hyperbolic branch (HB) of the radiative breaking of the electroweak symmetry. A part of the hyperbolic branch lies in the so called inversion region where the LSP neutralino $\chi_1^0$ becomes essentially a pure Higgsino and degenerate with the next to the lightest neutralino $\chi_2^0$ and the light chargino $\chi_1^{\pm}$. Thus some of the conventional signals for the observation of supersymmetry at colliders (e.g., the missing energy signals) do not operate in this region. On the other hand the inversion region contains a high degree of degeneracy of $\chi_1^0$, $\chi_2^0$, $\chi_1^{\pm}$ leading to coannihilations which allow for the satisfaction of the WMAP relic density constraints deep on the hyperbolic branch. Further, an analysis of the neutralino-proton cross sections in this region reveals that this region can still be accessible to dark matter experiments in the future. Constraints from $g_{\mu}-2$ and from $B^0_s\to \mu^+\mu^-$ are discussed. Future prospects are also discussed.Comment: 15 pages Latex. Invited talk at the IV International Conference on Non-accelerator New Physics (NANP'03), Dubna, Russia, June 23-28, 200

Electroweak Supersymmetry around the Electroweak Scale

Inspired by the phenomenological constraints, LHC supersymmetry and Higgs searches, dark matter search as well as string model building, we propose the electroweak supersymmetry around the electroweak scale: the squarks and/or gluinos are around a few TeV while the sleptons, sneutrinos, bino and winos are within one TeV. The Higgsinos can be either heavy or light. We consider bino as the dominant component of dark matter candidate, and the observed dark matter relic density is achieved via the neutralino-stau coannihilations. Considering the Generalized Minimal Supergravity (GmSUGRA), we show explicitly that the electroweak supersymmetry can be realized, and the gauge coupling unification can be preserved. With two Scenarios, we study the viable parameter spaces that satisfy all the current phenomenological constraints, and we present the concrete benchmark points. Furthermore, we comment on the fine-tuning problem and LHC searches.Comment: RevTex4, 28 pages, 8 figures, 8 tables, version to appear in EPJ

Cardiac troponin T is elevated and increases longitudinally in ALS patients.

Objective: To test whether high-sensitivity cardiac troponin T (hs-cTnT) could act as a diagnostic or prognostic biomarker in ALS, comparing hs-cTnT to neurofilament light (NfL). Methods: We performed a case-control study, including 150 ALS patients, 28 ALS mimics, and 108 healthy controls, and a follow-up study of the ALS patients, during 2014-2020 in Stockholm, Sweden. We compared concentrations of hs-cTnT in plasma and NfL in the cerebrospinal fluid between cases and controls. To evaluate the diagnostic performance, we calculated the area under the curve (AUC). Hazard ratios (HRs) were estimated from Cox models to assess associations between hs-cTnT and NfL at ALS diagnosis and risk of death. The longitudinal analysis measured changes of hs-cTnT and NfL since ALS diagnosis. Results: We noted higher levels of hs-cTnT in ALS patients (median: 16.5 ng/L) than in ALS mimics (11 ng/L) and healthy controls (6 ng/L). Both hs-cTnT and NfL could distinguish ALS patients from ALS mimics, with higher AUC noted for NfL (AUC 0.88; 95%CI 0.79-0.97). Disease progression correlated weakly with hs-cTnT (Pearson's r = 0.18, p = 0.04) and moderately with NfL (Pearson's r = 0.41, p < 0.001). Shorter survival was associated with higher levels of NfL at diagnosis (HR 1.08, 95%CI 1.04-1.11), but not hs-cTnT. hs-cTnT increased (12.61 ng/L per year, 95%CI 7.14-18.06) whereas NfL decreased longitudinally since ALS diagnosis. Conclusions: NfL is a stronger diagnostic and prognostic biomarker than hs-cTnT for ALS. However, hs-cTnT might constitute a disease progression biomarker as it increases longitudinally. The underlying causes for this increase need to be investigated

Realistic Standard Model Fermion Mass Relations in Generalized Minimal Supergravity (GmSUGRA)

Grand Unified Theories (GUTs) usually predict wrong Standard Model (SM) fermion mass relation m_e/m_{\mu} = m_d/m_s toward low energies. To solve this problem, we consider the Generalized Minimal Supergravity (GmSUGRA) models, which are GUTs with gravity mediated supersymmetry breaking and higher dimensional operators. Introducing non-renormalizable terms in the super- and K\"ahler potentials, we can obtain the correct SM fermion mass relations in the SU(5) model with GUT Higgs fields in the {\bf 24} and {\bf 75} representations, and in the SO(10) model. In the latter case the gauge symmetry is broken down to SU(3)_C X SU(2)_L X SU(2)_R X U(1)_{B-L}, to flipped SU(5)X U(1)_X, or to SU(3)_C X SU(2)_L X U(1)_1 X U(1)_2. Especially, for the first time we generate the realistic SM fermion mass relation in GUTs by considering the high-dimensional operators in the K\"ahler potential.Comment: JHEP style, 29 pages, no figure,references adde

Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase

Aspartate transcarbamoylase catalyzes the second step of de-novo pyrimidine biosynthesis. As malarial parasites lack pyrimidine salvage machinery and rely on de-novo production for growth and proliferation, this pathway is a target for drug discovery. Previously, an apo crystal structure of aspartate transcarbamoylase from Plasmodium falciparum (PfATC) in its T-state has been reported. Here we present crystal structures of PfATC in the liganded R-state as well as in complex with the novel inhibitor, 2,3-napthalenediol, identified by high-throughput screening. Our data shows that 2,3-napthalediol binds in close proximity to the active site, implying an allosteric mechanism of inhibition. Furthermore, we report biophysical characterization of 2,3-napthalenediol. These data provide a promising starting point for structure based drug design targeting PfATC and malarial de-novo pyrimidine biosynthesis

General Gauge and Anomaly Mediated Supersymmetry Breaking in Grand Unified Theories with Vector-Like Particles

In Grand Unified Theories (GUTs) from orbifold and various string constructions the generic vector-like particles do not need to form complete SU(5) or SO(10) representations. To realize them concretely, we present orbifold SU(5) models, orbifold SO(10) models where the gauge symmetry can be broken down to flipped SU(5) X U(1)_X or Pati-Salam SU(4)_C X SU(2)_L X SU(2)_R gauge symmetries, and F-theory SU(5) models. Interestingly, these vector-like particles can be at the TeV-scale so that the lightest CP-even Higgs boson mass can be lifted, or play the messenger fields in the Gauge Mediated Supersymmetry Breaking (GMSB). Considering GMSB, ultraviolet insensitive Anomaly Mediated Supersymmetry Breaking (AMSB), and the deflected AMSB, we study the general gaugino mass relations and their indices, which are valid from the GUT scale to the electroweak scale at one loop, in the SU(5) models, the flipped SU(5) X U(1)_X models, and the Pati-Salam SU(4)_C X SU(2)_L X SU(2)_R models. In the deflected AMSB, we also define the new indices for the gaugino mass relations, and calculate them as well. Using these gaugino mass relations and their indices, we may probe the messenger fields at intermediate scale in the GMSB and deflected AMSB, determine the supersymmetry breaking mediation mechanisms, and distinguish the four-dimensional GUTs, orbifold GUTs, and F-theory GUTs.Comment: RevTex4, 45 pages, 15 tables, version to appear in JHE

Lysobisphosphatidic acid controls endosomal cholesterol levels

Most cell types acquire cholesterol by endocytosis of circulating low density lipoprotein, but little is known about the mechanisms of intra-endosomal cholesterol transport and about the primary cause of its aberrant accumulation in the cholesterol storage disorder Niemann-Pick type C (NPC)

Supersymmetric Dark Matter and Yukawa Unification

An analysis of supersymmetric dark matter under the Yukawa unification constraint is given. The analysis utilizes the recently discovered region of the parameter space of models with gaugino mass nonuniversalities where large negative supersymmetric corrections to the b quark mass appear to allow $b-\tau$ unification for a positive $\mu$ sign consistent with the $b\to s+\gamma$ and $g_{\mu}-2$ constraints. In the present analysis we use the revised theoretical determination of $a_{\mu}^{SM}$ ($a_{\mu}= (g_{\mu}-2)/2$) in computing the difference $a_{\mu}^{exp}-a_{\mu}^{SM}$ which takes account of a reevaluation of the light by light contribution which has a positive sign. The analysis shows that the region of the parameter space with nonuniversalities of the gaugino masses which allows for unification of Yukawa couplings also contains regions which allow satisfaction of the relic density constraint. Specifically we find that the lightest neutralino mass consistent with the relic density constraint, $b\tau$ unification for SU(5) and $b-t-\tau$ unification for SO(10) in addition to other constraints lies in the region below 80 GeV. An analysis of the maximum and the minimum neutralino-proton scalar cross section for the allowed parameter space including the effect of a new determination of the pion-nucleon sigma term is also given. It is found that the full parameter space for this class of models can be explored in the next generation of proposed dark matter detectors.Comment: 28 pages,nLatex including 5 fig

Twenty Years of SUGRA

A brief review is given of the developments of mSUGRA and its extensions since the formulation of these models in 1982. Future directions and prospects are also discussed.Comment: Invited talk at the International Conference BEYOND-2003, Schloss Ringberg, Germany, June 10-14, 2003; 21 pages, Late