Observation of a narrow structure in the pp elastic scattering at T{sub kin} = 2.11 GeV

The angular dependences of the pp elastic scattering analyzing power, spin correlation, depolarization transfer were measured in the angular range from 60{degrees} to 97{degrees} CM at 14 energies between 1.96 and 2 .23 GeV. At fixed angles two maxima were observed in the analyzing Power energy dependence, both below and above 2.11 GeV. Furthermore a rapid decrease Of the spin correlation Parameter at 90{degrees} CM occurs around this energy. The observables allow determination of the absolute values of three nonvanishing pp amplitudes at 90{degrees}. The energy dependence of the spin-single amplitude shows a shoulder centered at 2.11 GeV, while the spin-triplet amplitudes are decreasing functions of energy snowing no evidence of structure. All experimental data are listed in tables and their energy dependences are shown in figures

Primary intestinal lymphangiectasia (Waldmann's disease)

Primary intestinal lymphangiectasia (PIL) is a rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia. PIL is generally diagnosed before 3 years of age but may be diagnosed in older patients. Prevalence is unknown. The main symptom is predominantly bilateral lower limb edema. Edema may be moderate to severe with anasarca and includes pleural effusion, pericarditis or chylous ascites. Fatigue, abdominal pain, weight loss, inability to gain weight, moderate diarrhea or fat-soluble vitamin deficiencies due to malabsorption may also be present. In some patients, limb lymphedema is associated with PIL and is difficult to distinguish lymphedema from edema. Exsudative enteropathy is confirmed by the elevated 24-h stool α1-antitrypsin clearance. Etiology remains unknown. Very rare familial cases of PIL have been reported. Diagnosis is confirmed by endoscopic observation of intestinal lymphangiectasia with the corresponding histology of intestinal biopsy specimens. Videocapsule endoscopy may be useful when endoscopic findings are not contributive. Differential diagnosis includes constrictive pericarditis, intestinal lymphoma, Whipple's disease, Crohn's disease, intestinal tuberculosis, sarcoidosis or systemic sclerosis. Several B-cell lymphomas confined to the gastrointestinal tract (stomach, jejunum, midgut, ileum) or with extra-intestinal localizations were reported in PIL patients. A low-fat diet associated with medium-chain triglyceride supplementation is the cornerstone of PIL medical management. The absence of fat in the diet prevents chyle engorgement of the intestinal lymphatic vessels thereby preventing their rupture with its ensuing lymph loss. Medium-chain triglycerides are absorbed directly into the portal venous circulation and avoid lacteal overloading. Other inconsistently effective treatments have been proposed for PIL patients, such as antiplasmin, octreotide or corticosteroids. Surgical small-bowel resection is useful in the rare cases with segmental and localized intestinal lymphangiectasia. The need for dietary control appears to be permanent, because clinical and biochemical findings reappear after low-fat diet withdrawal. PIL outcome may be severe even life-threatening when malignant complications or serous effusion(s) occur

Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design

International audienc

Studies on Halo Formation in a Long Magnetic Quadrupole FODO Channel First Experimental Results

A study is progress to prepare an experiment on the transport of an intense proton beam, with high optical qualities, through a periodic magnetic quadrupole FODO channel (29 periods). It is intended to provide a better understanding of how halo develops and can be controlled as a crucial issue for the design of high-intensity linear accelerators. Simulations were done showing that this experiment can be performed with a high-brightness proton, beam produced by a duoplasmatron source, with an energy of 500 keV and a current of tens of mA. Beam pulse length will be less than 1 ms and normalized emittance better than 1.p mm.mrad (90% of total beam).Thus, transverse tune can be sufficiently depressed in the transport channel to allow instabilities to grow and halo to develop or stay under control

Hemorrage after polypectomy

Les hémorragies sont les plus fréquentes des complications des polypectomies endoscopiques: les hémorragies importantes surviennent en moyenne dans 1,5 à 2% des cas mais n'entraînent qu'exceptionnellement le décès. Qu'elles apparaissent immédiatement ou qu'elles soient retardées, elles se tarissent en général spontanément ou peuvent bénéficier de gestes d'hémostase très efficaces, qu'il s'agisse d'une recoupe diathermique du pédicule restant ou de l'injection intra- et sous-muqueuse de substances vasoconstrictrices ou sclérosantes lorsqu'il n'y a rien à enserrer avec l'anse. Le respect d'un certain nombre de mesures dont l'apprentissage d'une bonne technique de polypectomie devrait prévenir une grande partie de ces hémorragie

Circular dichroism simulation shows a site-II-to-site-I displacement of human serum albumin-bound diclofenac by ibuprofen

Purpose: The purpose of this study was to confirm the hypothesis that a site-II-to-site-I displacement takes place when some nonsteroidal anti-inflammatory drugs are displaced by another drug from their high-affinity binding site to a site of lower affinity on human serum albumin (HSA).Methods: Diclofenac, sodium salt, was used as a representative example because of its prominent reversal of the Cotton effect. Effects of site-specific drugs on the free fraction of diclofenac were determined by equilibrium dialysis, and effects on induced circular dichroism (CD) of diclifenac bound to HSA were studied by CD and CD simulation techniques.Results: Ibuprofen, a site-II-specific drug, altered the CD spectrum of the diclofenac-HSA complex at a molar ratio of 0.5∶1 to that obtained at a higher ratio (5∶1) without ibuprofen. The induced CD spectrum obtained in the presence of ibuprofen was very similar to one that assumed that all diclofenac displaced from its high-affinity binding site (site II) became rebound to a lower-affinity site (site I). The rebinding could be influenced by a free energy linkage between the two sites which would make site I (or parts thereof) more suitable for diclofenac binding.Conclusion: We have confirmed the existence of a site II-to-site displacement, which is very striking and pharmacologically important, because the concentration of unbound drug being displaced is much lower than expected for a competitive mechanism