MTT assay done for the curcumin (drug) encapsulated coreshell in HeLa cell line.

<p>MTT assay done for the curcumin (drug) encapsulated coreshell in HeLa cell line.</p

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery - Fig 3

<p>Raman spectra of the four phases of coreshell preparation: (a) naked SPIONs, (b) after functionalizing with SDS, (c) after curcumin loading, (d) after encapsulating with biopolymer coating.</p

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery - Fig 5

<p>(a) SPIONs, (b) EDX spectrum of SPIONS, (c) SPIONs functionalized with SDS, (d) EDX spectrum of SPIONs functionalized with SDS (f) EDX spectrum of SPIONs functionalized and loaded with curcumin (g) SPIONs functionalized, loaded with curcumin and encapsulated with biopolymer coating, (h) EDX spectrum of SPIONs functionalized, loaded with curcumin and encapsulated with biopolymer coating.</p

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery - Fig 2

<p>FTIR spectra of the four phases of coreshell preparation: (a) naked SPIONs, (b) after functionalizing with SDS, (c) after curcumin loading, and (d) after encapsulating with biopolymer coating.</p

AFM images of the four phases of coreshell preparation.

<p>(a) SPIONs, (b) after functionalizing with SDS, (c) after curcumin loading, (d) after encapsulating with polymer coating.</p

Caspase 3 expression assay of time dependent drug release in HeLa cell line.

<p>Caspase 3 expression assay of time dependent drug release in HeLa cell line.</p

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery - Fig 4

<p>XRD spectra of the four phases of coreshell preparation: (a) naked SPIONs, (b) after functionalizing with SDS, (c) after curcumin loading, (d) after encapsulating with biopolymer coating.</p

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery - Fig 8

<p>Flow cytometric analysis of the time dependent apoptotic assay in HeLa cell line: (a) control–not treated (b) HeLa cell treated with coreshell for 2 hours, (c) HeLa cell treated with coreshell for 6 hours, (d) HeLa cell treated with coreshell for 12 hours, (e) HeLa cell treated with coreshell for 24 hours.</p

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery - Fig 1

<p>UV vis spectra of the four phases of coreshell preparation: (a) SPIONs, (b) after functionalizing with SDS, (c) after curcumin loading, (d) after encapsulating with biopolymer coating.</p