Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor

Treatment of MCF-7 cells with 1.0 μM 3-methylcholanthrene (MC) caused a decrease in cell proliferation and [3H]thymidine uptake whereas no effects were observed at a lower (0.1 μM) concentration. Co-treatment of the cells with 1 nM 17β-estradiol plus 0.1 or 1.0 μ MC resulted in a significant inhibition of 17β-estradiol-induced growth and [3H]thymidine uptake. MC also inhibited the 17β-estradiol-induced secretion of the 52 kDa protein (procathepsin D) in MCF-7 cells and caused a concentration-dependent decrease in the nuclear estrogen receptor (ER) as determined by either velocity sedimentation analysis or immunoquantitation with human ER antibodies. The effects of several different polynuclear aromatic hydrocarbon (PAH) congeners on the nuclear ER in MCF-7 cells were also determined. Only those congeners which bound to the aryl hydrocarbon (Ah) receptor, namely benzo[a]pyrene, benz[a]anthracene, 7,12-dimethylbenz[a]anthracene and MC, caused a decrease in nuclear ER levels. In contrast, benzo[ghi]perylene, a congener which did not bind to the Ah receptor did not affect nuclear ER levels in MCF-7 cells. Moreover, with some congeners the decrease in nuclear ER levels could be observed without any significant induction of ethoxyresorufin O-deethylase activity, a P4501A1-dependent monooxygenase. These data suggest that the Ah receptor liganded with MC and related PAHs induced a broad spectrum of antiestrogenic responses in MCF-7 cells and complements the results of previous studies which report the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and other halogenated aromatics which are also Ah receptor agonists

Using Strategy Improvement to Stay Alive

We design a novel algorithm for solving Mean-Payoff Games (MPGs). Besides solving an MPG in the usual sense, our algorithm computes more information about the game, information that is important with respect to applications. The weights of the edges of an MPG can be thought of as a gained/consumed energy -- depending on the sign. For each vertex, our algorithm computes the minimum amount of initial energy that is sufficient for player Max to ensure that in a play starting from the vertex, the energy level never goes below zero. Our algorithm is not the first algorithm that computes the minimum sufficient initial energies, but according to our experimental study it is the fastest algorithm that computes them. The reason is that it utilizes the strategy improvement technique which is very efficient in practice

Selfconsistent gauge-invariant theory of in-plane infrared response of high-Tc cuprate superconductors involving spin fluctuations

We report on results of our theoretical study of the in-plane infrared conductivity of the high-Tc cuprate superconductors using the model where charged planar quasiparticles are coupled to spin fluctuations. The computations include both the renormalization of the quasiparticles and the corresponding modification of the current-current vertex function (vertex correction), which ensures gauge invariance of the theory and local charge conservation in the system. The incorporation of the vertex corrections leads to an increase of the total intraband optical spectral weight (SW) at finite frequencies, a SW transfer from far infrared to mid infrared, a significant reduction of the SW of the superconducting condensate, and an amplification of characteristic features in the superconducting state spectra of the inverse scattering rate 1/tau. We also discuss the role of selfconsistency and propose a new interpretation of a kink occurring in the experimental low temperature spectra of 1/tau around 1000cm^{-1}.Comment: 9 pages with 6 figures, submitted to Physical Review

Will jets reduce the elliptic flow at LHC, while decays of resonances restore the constituent quark scaling?

Formation and evolution of the elliptic flow pattern in Pb+Pb collisions at sqrt{s}=5.5 ATeV and in Au+Au collisions at sqrt{s}=200 AGeV are analyzed for different hadron species within the framework of HYDJET++ Monte-Carlo model. The model contains both hydrodynamic state and jets, thus allowing for a study of the interplay between the soft and hard processes. It is found that jets are terminating the rise of the elliptic flow with increasing transverse momentum. Since jets are more influential at LHC compared to RHIC, the elliptic flow at LHC should be weaker than that at RHIC. The influence of resonance decays on particle elliptic flow is investigated also. These final state interactions enhance the low-p_T part of the v_2 of pions and light baryons, and work towards the fulfilment of idealized constituent quark scaling.Comment: 8 pages, 9 figures, 3 table

Collective and fractal properties of pion jets in the four-velocity space at intermediate energies

Experimental results are presented for study of collective and fractal properties of soft pion jets in the space of relative four-dimensional velocities. Significant decreasing is obtained for mean square of second particle distances from jet axis for pion-proton interactions at initial energies $\sim 3$ GeV in comparison with hadron-nuclear collisions at close energies. The decreasing results in power dependence of distance variable on collision energy for range $\sim 2 - 4$ GeV. The observation allows us to estimate the low boundary of manifestation of color degree of freedom in pion jet production. Cluster dimension values were deduced for pion jets in various reactions. Fractional values of this dimension indicate on the manifestation of fractal-like properties by pion jets. Changing of mean kinetic energy of jet particles and fractal dimension with initial energy increasing is consistent with suggestion for presence of color degrees of freedom in pion jet production at intermediate energies.Comment: The conference "Physics of fundamental interactions". ITEP, Moscow, Russia. November 23 - 27, 200

Spectroscopic distinction between the normal state pseudogap and the superconducting gap of cuprate high T_{c} superconductors

We report on broad-band infrared ellipsometry measurements of the c-axis conductivity of underdoped RBa_{2}Cu_{3}O_{7-d} (R=Y, Nd, and La) single crystals. Our data provide a detailed account of the spectral weight (SW) redistributions due to the normal state pseudogap (PG) and the superconducting (SC) gap. They show that these phenomena involve different energy scales, exhibit distinct doping dependencies and thus are likely of different origin. In particular, the SW redistribution in the PG state closely resembles the one of a conventional charge- or spin density wave (CDW or SDW) system.Comment: 4 pages, 4 figure