Stable L\'{e}vy diffusion and related model fitting

A fractional advection-dispersion equation (fADE) has been advocated for heavy-tailed flows where the usual Brownian diffusion models fail. A stochastic differential equation (SDE) driven by a stable L\'{e}vy process gives a forward equation that matches the space-fractional advection-dispersion equation and thus gives the stochastic framework of particle tracking for heavy-tailed flows. For constant advection and dispersion coefficient functions, the solution to such SDE itself is a stable process and can be derived easily by least square parameter fitting from the observed flow concentration data. However, in a more generalized scenario, a closed form for the solution to a stable SDE may not exist. We propose a numerical method for solving/generating a stable SDE in a general set-up. The method incorporates a discretized finite volume scheme with the characteristic line to solve the fADE or the forward equation for the Markov process that solves the stable SDE. Then we use a numerical scheme to generate the solution to the governing SDE using the fADE solution. Also, often the functional form of the advection or dispersion coefficients are not known for a given plume concentration data to start with. We use a Levenberg--Marquardt (L-M) regularization method to estimate advection and dispersion coefficient function from the observed data (we present the case for a linear advection) and proceed with the SDE solution construction described above.Comment: Published at https://doi.org/10.15559/18-VMSTA106 in the Modern Stochastics: Theory and Applications (https://vmsta.org/) by VTeX (http://www.vtex.lt/

Nanomedicines for the management of diabetic nephropathy: present progress and prospects

Diabetic nephropathy (DN) is a serious microvascular consequence of diabetes mellitus (DM), posing an encumbrance to public health worldwide. Control over the onset and progress of DN depend heavily on early detection and effective treatment. DN is a major contributor to end-stage renal disease, and a complete cure is yet to be achieved with currently available options. Though some therapeutic molecules have exhibited promise in treating DN complications, their poor solubility profile, low bioavailability, poor permeation, high therapeutic dose and associated toxicity, and low patient compliance apprehend their clinical usefulness. Recent research has indicated nano-systems as potential theranostic platforms displaying futuristic promise in the diagnosis and treatment of DN. Early and accurate diagnosis, site-specific delivery and retention by virtue of ligand conjugation, and improved pharmacokinetic profile are amongst the major advantages of nano-platforms, defining their superiority. Thus, the emergence of nanoparticles has offered fresh approaches to the possible diagnostic and therapeutic strategies regarding DN. The present review corroborates an updated overview of different types of nanocarriers regarding potential approaches for the diagnosis and therapy of DN

Targeting Mitochondrial Cell Death Pathway to Overcome Drug Resistance with a Newly Developed Iron Chelate

Background: Multi drug resistance (MDR) or cross-resistance to multiple classes of chemotherapeutic agents is a major obstacle to successful application of chemotherapy and a basic problem in cancer biology. The multidrug resistance gene, MDR1, and its gene product P-glycoprotein (P-gp) are an important determinant of MDR. Therefore, there is an urgent need for development of novel compounds that are not substrates of P-glycoprotein and are effective against drug-resistant cancer. Methodology/Principal Findings: In this present study, we have synthesized a novel, redox active Fe (II) complex (chelate), iron N- (2-hydroxy acetophenone) glycinate (FeNG). The structure of the complex has been determined by spectroscopic means. To evaluate the cytotoxic effect of FeNG we used doxorubicin resistant and/or sensitive T lymphoblastic leukemia cells and show that FeNG kills both the cell types irrespective of their MDR phenotype. Moreover, FeNG induces apoptosis in doxorubicin resistance T lymphoblastic leukemia cell through mitochondrial pathway via generation reactive oxygen species (ROS). This is substantiated by the fact that the antioxidant N-acetyle-cysteine (NAC) could completely block ROS generation and, subsequently, abrogated FeNG induced apoptosis. Therefore, FeNG induces the doxorubicin resistant T lymphoblastic leukemia cells to undergo apoptosis and thus overcome MDR. Conclusion/Significance: Our study provides evidence that FeNG, a redox active metal chelate may be a promising ne

Appraisal of trawl fisheries of India with special reference on the changing trends in bycatch utilization

Trawl fisheries sector account more than 50% of the marine fisheries production of India. Annual average fish landing from trawlers was 17, 21, 000 t (2008-2011), which formed around 51 % of the marine fish landing of the coast. In this about 51% of the catch was contributed by the west coast and remaining by the east coast of India. Recent studies of the trawl fishery in India have shown that incidental catches/low value bycatch (LVB) landing and utilization has increased over the period of time. The present study is based on the data collected from major trawl landing centres along the coast of India during the period 2008-2011.The estimated landing of low value bycatch (LVB) in trawl fisheries, increased from 14 % in 2008 to 25 % in 2011, which is reflected as reduction in discard volume by trawlers. On an average the highest quantity of LVB landed was in Veraval (50,000 t) and in Mangalore, LVB landing increased from 3% in (3000 t) in 2008 to 26 % (12,000 t) in 2011.In Mumbai, the percentage of trash fish landed remained around 5% during the study period. In Calicut, the LVB landed in 2011 contributed 26% to the total landings by the trawl. In Kochi, Kerala the total LVB landed in 2011 was 1,992 t forming 7.2 % of the total landing. In Chennai, Tamilnadu, the LVB landing which was 13 % in 2008 increased to 17% in 2011, while in Visakhapatanam, Andhra Pradesh, LVB landing showed a steady increase from 2% in 2008 to 21% in 2011. The landing centre price for LVB showed an increasing trend due to increased demand for trash fish for the production of fish meal and fertilizer. The dominance of finfishes in LVB found to increase the value of LVB and the value realized for 30,000 t of LVB in Available online at: www.mbai.org.in doi: 10.6024/jmbai.2013.55.2.01765-11 Mangalore in 2011 ( Rs.280 million) was more than that realized for 50,000 t of LVB in Veraval (Rs.200 million). A disturbing trend observed from the studies in Mangalore was that, the sardines in trash fetches higher price in some seasons (upto Rs.16/kg) compared to a lower price when landed in fresh form, and the percentage of sardines in LVB is found to be very high (24% in 2010). This trend may cause a severe threat to the protein availability to the rural poor. Looking at the trend of trawl landing during 2008-2012, it is seen that even though the trawl landing showed an increase over the period of time, the edible portion of the trawl landing did not show any significant increase rather showing general declining trend. Study on the bycatch from different centres along the coast of India showed that as many as 237 species / groups of marine fauna with juveniles of commercially important fishes were landed as LVB. Increase in utilization of LVB (which was discarded earlier) from trawl fishery, a trend which is market driven and its implication on the ecosystem and marine fisheries production of the country is discussed in this paper

A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells

At the early stages of carcinogenesis, the induction of tumor specific T cell mediated immunity seems to block the tumor growth and give protective anti-tumor immune response. However, tumor associated macrophages (TAMs) might play an immunosuppressive role and subvert this anti tumor immunity leading to tumor progression and metastasis.The Cu (II) complex, (chelate), copper N-(2-hydroxy acetophenone) glycinate (CuNG), synthesized by us, has previously been shown to have a potential usefulness in immunotherapy of multiple drug resistant cancers. The current study demonstrates that CuNG treatment of TAMs modulates their status from immunosuppressive to proimmunogenic nature. Interestingly, these activated TAMs produced high levels of IL-12 along with low levels of IL-10 that not only allowed strong Th1 response marked by generation of high levels of IFN-gamma but also reduced activation induced T cell death. Similarly, CuNG treatment of peripheral blood monocytes from chemotherapy and/or radiotherapy refractory cancer patients also modulated their cytokine status. Most intriguingly, CuNG treated TAMs could influence reprogramming of TGF-beta producing CD4(+)CD25(+) T cells toward IFN-gamma producing T cells.Our results show the potential usefulness of CuNG in immunotherapy of drug-resistant cancers through reprogramming of TAMs that in turn reprogram the T cells and reeducate the T helper function to elicit proper anti-tumorogenic Th1 response leading to effective reduction in tumor growth

Status of fisheries development in West Bengal

The state of West Bengal having a coastline of 158 km, (including the Hoogly Matlah estuary), is endowed with a wide range of fishery resources from the Bay of Bengal right upto the Himalayan Foothills. (Table I). With an esti mated fishery population of 14.87 lakhs (2001 - '02), comprising both marine and inland