4 research outputs found

    Two new bioactive iridoids from Rothmannia wittii

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    The first reported study of the isolation and identification of compounds from the bark and fruit of Rothmannia wittii yielded two new iridoids, 6β-hydroxy-10-O-acetylgenipin (1) and 10-O-acetylmacrophyllide (2) together with six known iridoids; 6β-hydroxygenipin (3), genipin (4), garjasmine (5), cerbinal (6), and mixture of β-gardiol (7) and α-gardiol (8); benzoic acid (9); vanillic acid (10); and stigmasterol (11). Their structures were elucidated by spectroscopic methods. Iridoid 1 showed antimycobacterial activity against Mycobacterium tuberculosis with a MIC value of 12.50 μg/mL. Iridoid 2 showed cytotoxicity against the NCI-H187 cancer cell line with an IC50 value of 6.82 μg/mL. In addition, 2 and 5 exhibited weak cytotoxic activity against KB and MCF-7 cell lines, while 4 was active against the NCI-H187 cancer cell line

    Two new flavanonols from the bark of <i>Akschindlium godefroyanum</i>

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    <div><p>The first phytochemical investigation of the bark of <i>Akschindlium godefroyanum</i> (Kuntze) H. Ohashi (Fabaceae), a Thai herbal medicine, resulted in the isolation of two new flavanonols, 7,3′,5′-trihydroxy-5-methoxyflavanonol (<b>1</b>) and 7,4′-dihydroxy-5,3′-dimethoxyflavanonol (<b>2</b>), and eight known compounds comprising one flavonol, geraldol (<b>3</b>); three flavanonols, (+)-taxifolin (<b>4</b>), (+)-fustin (<b>5</b>) and aromadendrin 5-methyl ether (<b>6</b>); one catechin, (–)-epigallocatechin (<b>7</b>); one triterpenoid, lupeol (<b>8</b>); one steroid, stigmasterol (<b>9</b>) and one steroid glycoside, stigmasterol-3-<i>O</i>-β-d-glucoside (<b>10</b>). Their structures were identified by spectroscopic methods.</p></div
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