A study of a non-deepening tropical disturbance

Data from research vessel, instrumented research aircraft, and Tiros VI and Tiros VII SATELLITES to study nondeepening tropical disturbanc

Antidepressants in the Management of Chronic Pain Syndromes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90213/1/j.1875-9114.1990.tb02582.x.pd

Targeted Maximum Likelihood Estimation for Dynamic Treatment Regimes in Sequential Randomized Controlled Trials

Sequential Randomized Controlled Trials (SRCTs) are rapidly becoming essential tools in the search for optimized treatment regimes in ongoing treatment settings. Analyzing data for multiple time-point treatments with a view toward optimal treatment regimes is of interest in many types of afflictions: HIV infection, Attention Deficit Hyperactivity Disorder in children, leukemia, prostate cancer, renal failure, and many others. Methods for analyzing data from SRCTs exist but they are either inefficient or suffer from the drawbacks of estimating equation methodology. We describe an estimation procedure, targeted maximum likelihood estimation (TMLE), which has been fully developed and implemented in point treatment settings, including time to event outcomes, binary outcomes and continuous outcomes. Here we develop and implement TMLE in the SRCT setting. As in the former settings, the TMLE procedure is targeted toward a pre-specified parameter of the distribution of the observed data, and thereby achieves important bias reduction in estimation of that parameter. As with the so-called Augmented Inverse Probability of Censoring Weight (A-IPCW) estimator, TMLE is double-robust and locally efficient. We report simulation results corresponding to two data-generating distributions from a longitudinal data structure

The He abundance in the metal-deficient blue compact dwarf galaxies Tol 1214-277 and Tol 65

We present high-quality Keck telescope spectroscopic observations of the two metal-deficient blue compact dwarf (BCD) galaxies Tol 1214-277 and Tol 65. These data are used to derive the heavy-element and helium abundances. We find that the oxygen abundances in Tol 1214-277 and Tol 65 are the same, 12+logO/H=7.54+/-0.01, or Zsun/24, despite the different ionization conditions in these galaxies. The nitrogen-to-oxygen abundance ratio in both galaxies is logN/O=-1.64+/-0.02 and lies in the narrow range found for the other most metal-deficient BCDs. We use the five strongest HeI emission lines 3889, 4471, 5876, 6678 and 7065, to correct self-consistently their intensities for collisional and fluorescent enhancement mechanisms and to derive the He abundance. Underlying stellar absorption is found to be important for the HeI 4471 emission line in both galaxies, being larger in Tol 65. The weighted He mass fractions in Tol 1214-277 and Tol 65 are respectively Y=0.2458+/-0.0039 and 0.2410+/-0.0050 when the three HeI emission lines, 4471, 5876 and 6678, are used, and are, respectively, 0.2466+/-0.0043 and 0.2463+/-0.0057 when the HeI 4471 emission line is excluded. These values are in very good agreement with recent measurements of the He mass fraction in others of the most metal-deficient BCDs by Izotov and coworkers. We find that the combined effect of the systematic uncertainties due to the underlying HeI stellar absorption lines, ionization and temperature structure of the HII region and collisional excitation of the hydrogen emission lines is likely small, not exceeding ~2% (the error is 2sigma). Our results support the validity of the standard big bang model of nucleosynthesis.Comment: 22 pages, 3 Postscript figures, accepted for publication in the Astrophysical Journa

KECK HIRES Spectroscopy of APM 08279+5255

With an optical R-band magnitude of 15.2, the recently discovered z=3.911 BAL quasar APM 08279+5255 is an exceptionally bright high redshift source. Its brightness has allowed us to acquire a high signal-to-noise ratio (~100), high resolution (~6 km/s) spectrum using the HIRES echelle spectrograph on the 10-m Keck I telescope. Given the quality of the data, these observations provide an unprecedented view of associated and intervening absorption systems. Here we announce the availability of this spectrum to the general astronomical community and present a brief analysis of some of its main features.Comment: 21 pages including 5 figures. Accepted for publication by PAS

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth. This overview is a combined write-up of talks given at this conference and in NASA's Goddard Space Flight Center