The Student Movement Volume 108 Issue 2: World Changers Assemble!

HUMANS Meet Pastor Taurus Montgomery, Colin Cha Uniting AULA with Sofia Oudri, Grace No World Changers Take On Changing the World, Savannah Tyler ARTS & ENTERTAINMENT Bewitched: An Album for the Fall Season, Lexie Dunham Music Notes for Change Day, Aiko J. Ayala Rios Processing Through Poetry: Raw & Real, Madison Vath NEWS Being Unstoppable: AU Fall Week of Prayer, Jonathan Clough FIBA Games Spark Questions for Competing Nations Ahead of the \u2724 Summer Olympics, Andrew Francis Honors\u27 Agape Feast Starts New Year of Faith and Fellowship, Andrew Francis IDEAS A Life Worth Living, Reagan Westerman The Victoria\u27s Secret Fashion Show Returns: Is it a Marketing Tactic or Genuine Change?, Daena Holbrook PULSE AU Sports, Alyssa Caruthers More Change Day Experiences, Various Students The Strange Thing About Service, Wambui Karanja Uplifting Spaces on Campus: Reflections from Nicole Compton-Gray, Nicole Compton-Gray LAST WORD An Advertising-Free Zone, Scott Moncrieffhttps://digitalcommons.andrews.edu/sm-108/1001/thumbnail.jp

The Student Movement Volume 108 Issue 8: Conducting Us Into The Season

HUMANS Eating Healthier at Andrews, Brooklyn Anderson Honors Research with Shania Watts, Grace No Social Media: Is It Really Social?, Colin Cha ARTS & ENTERTAINMENT Journey to the Marvelous God - A double conducting recital, Aiko J. Ayala Rios Love, Murder, and Secrets: A Night At The MSU French Film Festival, Amelia Stefanescu What To Do About National Clean Out Your Refrigerator Day, Nate Miller Places to Go: The Lake Michigan College Mendel Center, Madison Vath NEWS Argentina Election Article, Regan McCain Qualitative Research Writing Group: Your Research Accountability Partner, Melissa Moore Self-Driving Taxis, Katie Davis Students\u27 reactions to Andrews\u27s National Ranking, Kiheon Chung Upcoming Winter Events, Melissa Moore IDEAS Morally Gray, Katie Davis Red and Green Flags, Ruben Colón Remembering Matthew Perry, Corinna Bevier SDAs and The Big Bang: A Survey, Erin Beers Shoot Your Shot - Or Maybe Not?, Regan Westerman PULSE Burnout vs. Laziness: What\u27s The Difference?, Lexie Dunham How Habits Happen, Anna Rybachek The Mauricio Fund, Elianna Fisher LAST WORD Reality for a Second-Generation Immigrant, Gio Leehttps://digitalcommons.andrews.edu/sm-108/1007/thumbnail.jp

Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

“Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod’s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices

Testing Propositions Derived from Twitter Studies: Generalization and Replication in Computational Social Science

Replication is an essential requirement for scientific discovery. The current study aims to generalize and replicate 10 propositions made in previous Twitter studies using a representative dataset. Our findings suggest 6 out of 10 propositions could not be replicated due to the variations of data collection, analytic strategies employed, and inconsistent measurements. The study’s contributions are twofold: First, it systematically summarized and assessed some important claims in the field, which can inform future studies. Second, it proposed a feasible approach to generating a random sample of Twitter users and its associated ego networks, which might serve as a solution for answering social-scientific questions at the individual level without accessing the complete data archive.published_or_final_versio

Diffusion of MMPs on the Surface of Collagen Fibrils: The Mobile Cell Surface – Collagen Substratum Interface

Remodeling of the extracellular matrix catalyzed by MMPs is central to morphogenetic phenomena during development and wound healing as well as in numerous pathologic conditions such as fibrosis and cancer. We have previously demonstrated that secreted MMP-2 is tethered to the cell surface and activated by MT1-MMP/TIMP-2-dependent mechanism. The resulting cell-surface collagenolytic complex (MT1-MMP)2/TIMP-2/MMP-2 can initiate (MT1-MMP) and complete (MMP-2) degradation of an underlying collagen fibril. The following question remained: What is the mechanism of substrate recognition involving the two structures of relatively restricted mobility, the cell surface enzymatic complex and a collagen fibril embedded in the ECM? Here we demonstrate that all the components of the complex are capable of processive movement on a surface of the collagen fibril. The mechanism of MT1-MMP movement is a biased diffusion with the bias component dependent on the proteolysis of its substrate, not adenosine triphosphate (ATP) hydrolysis. It is similar to that of the MMP-1 Brownian ratchet we described earlier. In addition, both MMP-2 and MMP-9 as well as their respective complexes with TIMP-1 and -2 are capable of Brownian diffusion on the surface of native collagen fibrils without noticeable dissociation while the dimerization of MMP-9 renders the enzyme immobile. Most instructive is the finding that the inactivation of the enzymatic activity of MT1-MMP has a detectable negative effect on the cell force developed in miniaturized 3D tissue constructs. We propose that the collagenolytic complex (MT1-MMP)2/TIMP-2/MMP-2 represents a Mobile Cell Surface – Collagen Substratum Interface. The biological implications of MT1-MMP acting as a molecular ratchet tethered to the cell surface in complex with MMP-2 suggest a new mechanism for the role of spatially regulated peri-cellular proteolysis in cell-matrix interactions

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field