113 research outputs found
High-fidelity transmission of entanglement over a high-loss freespace channel
Quantum entanglement enables tasks not possible in classical physics. Many
quantum communication protocols require the distribution of entangled states
between distant parties. Here we experimentally demonstrate the successful
transmission of an entangled photon pair over a 144 km free-space link. The
received entangled states have excellent, noise-limited fidelity, even though
they are exposed to extreme attenuation dominated by turbulent atmospheric
effects. The total channel loss of 64 dB corresponds to the estimated
attenuation regime for a two-photon satellite quantum communication scenario.
We confirm that the received two-photon states are still highly entangled by
violating the CHSH inequality by more than 5 standard deviations. From a
fundamental point of view, our results show that the photons are virtually not
subject to decoherence during their 0.5 ms long flight through air, which is
encouraging for future world-wide quantum communication scenarios.Comment: 5 pages, 3 figures, replaced paper with published version, added
journal referenc
Measuring measurement
Measurement connects the world of quantum phenomena to the world of classical
events. It plays both a passive role, observing quantum systems, and an active
one, preparing quantum states and controlling them. Surprisingly - in the light
of the central status of measurement in quantum mechanics - there is no general
recipe for designing a detector that measures a given observable. Compounding
this, the characterization of existing detectors is typically based on partial
calibrations or elaborate models. Thus, experimental specification (i.e.
tomography) of a detector is of fundamental and practical importance. Here, we
present the realization of quantum detector tomography: we identify the optimal
positive-operator-valued measure describing the detector, with no ancillary
assumptions. This result completes the triad, state, process, and detector
tomography, required to fully specify an experiment. We characterize an
avalanche photodiode and a photon number resolving detector capable of
detecting up to eight photons. This creates a new set of tools for accurately
detecting and preparing non-classical light.Comment: 6 pages, 4 figures,see video abstract at
http://www.quantiki.org/video_abstracts/0807244
Potential Energy Surface for H_2 Dissociation over Pd(100)
The potential energy surface (PES) of dissociative adsorption of H_2 on
Pd(100) is investigated using density functional theory and the full-potential
linear augmented plane wave (FP-LAPW) method. Several dissociation pathways are
identified which have a vanishing energy barrier. A pronounced dependence of
the potential energy on ``cartwheel'' rotations of the molecular axis is found.
The calculated PES shows no indication of the presence of a precursor state in
front of the surface. Both results indicate that steering effects determine the
observed decrease of the sticking coefficient at low energies of the H_2
molecules. We show that the topology of the PES is related to the dependence of
the covalent H(s)-Pd(d) interactions on the orientation of the H_2 molecule.Comment: RevTeX, 8 pages, 5 figures in uufiles forma
Ab initio Quantum and ab initio Molecular Dynamics of the Dissociative Adsorption of Hydrogen on Pd(100)
The dissociative adsorption of hydrogen on Pd(100) has been studied by ab
initio quantum dynamics and ab initio molecular dynamics calculations. Treating
all hydrogen degrees of freedom as dynamical coordinates implies a high
dimensionality and requires statistical averages over thousands of
trajectories. An efficient and accurate treatment of such extensive statistics
is achieved in two steps: In a first step we evaluate the ab initio potential
energy surface (PES) and determine an analytical representation. Then, in an
independent second step dynamical calculations are performed on the analytical
representation of the PES. Thus the dissociation dynamics is investigated
without any crucial assumption except for the Born-Oppenheimer approximation
which is anyhow employed when density-functional theory calculations are
performed. The ab initio molecular dynamics is compared to detailed quantum
dynamical calculations on exactly the same ab initio PES. The occurence of
quantum oscillations in the sticking probability as a function of kinetic
energy is addressed. They turn out to be very sensitive to the symmetry of the
initial conditions. At low kinetic energies sticking is dominated by the
steering effect which is illustrated using classical trajectories. The steering
effects depends on the kinetic energy, but not on the mass of the molecules.
Zero-point effects lead to strong differences between quantum and classical
calculations of the sticking probability. The dependence of the sticking
probability on the angle of incidence is analysed; it is found to be in good
agreement with experimental data. The results show that the determination of
the potential energy surface combined with high-dimensional dynamical
calculations, in which all relevant degrees of freedon are taken into account,
leads to a detailed understanding of the dissociation dynamics of hydrogen at a
transition metal surface.Comment: 15 pages, 9 figures, subm. to Phys. Rev.
The role of an extended medial column arthrodesis for Charcot midfoot neuroarthropathy
The etiology of diabetic Charcot neuroarthropathy involving the midfoot often includes an inciting traumatic event or repetitive micro-trauma from an uncompensated biomechanical imbalance that potentiates an incompletely understood pathway leading to a rocker-bottom foot deformity and ulceration. In the setting of a severe Charcot foot fracture and/or dislocation with obvious osseous instability, diagnostic delay can potentiate the limb-threatening sequelae of infected midfoot ulcerations in this patient population. In this article, the authors discuss the thought process as well as the advantages of performing an extended medial column arthrodesis for selected Charcot midfoot deformities
Free-Space distribution of entanglement and single photons over 144 km
Quantum Entanglement is the essence of quantum physics and inspires
fundamental questions about the principles of nature. Moreover it is also the
basis for emerging technologies of quantum information processing such as
quantum cryptography, quantum teleportation and quantum computation. Bell's
discovery, that correlations measured on entangled quantum systems are at
variance with a local realistic picture led to a flurry of experiments
confirming the quantum predictions. However, it is still experimentally
undecided whether quantum entanglement can survive global distances, as
predicted by quantum theory. Here we report the violation of the
Clauser-Horne-Shimony-Holt (CHSH) inequality measured by two observers
separated by 144 km between the Canary Islands of La Palma and Tenerife via an
optical free-space link using the Optical Ground Station (OGS) of the European
Space Agency (ESA). Furthermore we used the entangled pairs to generate a
quantum cryptographic key under experimental conditions and constraints
characteristic for a Space-to-ground experiment. The distance in our experiment
exceeds all previous free-space experiments by more than one order of magnitude
and exploits the limit for ground-based free-space communication; significantly
longer distances can only be reached using air- or space-based platforms. The
range achieved thereby demonstrates the feasibility of quantum communication in
space, involving satellites or the International Space Station (ISS).Comment: 10 pages including 2 figures and 1 table, Corrected typo
A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation
Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that takes place both in the cytoplasm and on the membrane. To model and analyze such multicompartmental processes, we developed a lattice-based Monte Carlo method, Spatiocyte that supports RD in volume and surface compartments at single molecule resolution. Stochasticity in RD and the excluded volume effect brought by intracellular molecular crowding, both of which can significantly affect RD and thus, cellular processes, are also supported. We verified the method by comparing simulation results of diffusion, irreversible and reversible reactions with the predicted analytical and best available numerical solutions. Moreover, to directly compare the localization patterns of molecules in fluorescence microscopy images with simulation, we devised a visualization method that mimics the microphotography process by showing the trajectory of simulated molecules averaged according to the camera exposure time. In the rod-shaped bacterium _Escherichia coli_, the division site is suppressed at the cell poles by periodic pole-to-pole oscillations of the Min proteins (MinC, MinD and MinE) arising from carefully orchestrated RD in both cytoplasm and membrane compartments. Using Spatiocyte we could model and reproduce the _in vivo_ MinDE localization dynamics by accounting for the established properties of MinE. Our results suggest that the MinE ring, which is essential in preventing polar septation, is largely composed of MinE that is transiently attached to the membrane independently after recruited by MinD. Overall, Spatiocyte allows simulation and visualization of complex spatial and reaction-diffusion mediated cellular processes in volumes and surfaces. As we showed, it can potentially provide mechanistic insights otherwise difficult to obtain experimentally
Domain Organization of Long Signal Peptides of Single-Pass Integral Membrane Proteins Reveals Multiple Functional Capacity
Targeting signals direct proteins to their extra - or intracellular destination such as the plasma membrane or cellular organelles. Here we investigated the structure and function of exceptionally long signal peptides encompassing at least 40 amino acid residues. We discovered a two-domain organization (“NtraC model”) in many long signals from vertebrate precursor proteins. Accordingly, long signal peptides may contain an N-terminal domain (N-domain) and a C-terminal domain (C-domain) with different signal or targeting capabilities, separable by a presumably turn-rich transition area (tra). Individual domain functions were probed by cellular targeting experiments with fusion proteins containing parts of the long signal peptide of human membrane protein shrew-1 and secreted alkaline phosphatase as a reporter protein. As predicted, the N-domain of the fusion protein alone was shown to act as a mitochondrial targeting signal, whereas the C-domain alone functions as an export signal. Selective disruption of the transition area in the signal peptide impairs the export efficiency of the reporter protein. Altogether, the results of cellular targeting studies provide a proof-of-principle for our NtraC model and highlight the particular functional importance of the predicted transition area, which critically affects the rate of protein export. In conclusion, the NtraC approach enables the systematic detection and prediction of cryptic targeting signals present in one coherent sequence, and provides a structurally motivated basis for decoding the functional complexity of long protein targeting signals
Photonic quantum technologies
The first quantum technology, which harnesses uniquely quantum mechanical
effects for its core operation, has arrived in the form of commercially
available quantum key distribution systems that achieve enhanced security by
encoding information in photons such that information gained by an eavesdropper
can be detected. Anticipated future quantum technologies include large-scale
secure networks, enhanced measurement and lithography, and quantum information
processors, promising exponentially greater computation power for particular
tasks. Photonics is destined for a central role in such technologies owing to
the need for high-speed transmission and the outstanding low-noise properties
of photons. These technologies may use single photons or quantum states of
bright laser beams, or both, and will undoubtably apply and drive
state-of-the-art developments in photonics
Single-nucleotide polymorphism associations with preterm delivery: a case-control replication study and meta-analysis
BackgroundThe aim of this study was to replicate single-nucleotide polymorphism (SNP) associations with preterm birth (PTB; birth at MethodsSpontaneous PTB cases and controls were selected from an existing cohort. Candidate SNPs were taken from an existing genotype panel. A systematic review was conducted for each SNP in the panel to determine suitability as a PTB candidate. Those with significant associations previously reported in Caucasians were selected for replication. Candidate SNPs were already genotyped in cases and controls and clinical data were accessed from state perinatal and cerebral palsy databases. Association analysis was conducted between each SNP and PTB, and meta-analysis was conducted if there were ≥ 3 studies in the literature. Maternal and fetal SNPs were considered as separate candidates.ResultsA cohort of 170 cases and 583 controls was formed. Eight SNPs from the original panel of genotyped SNPs were selected as PTB candidates and for replication on the basis of systematic literature review results. In our cohort, fetal factor V Leiden (FVL) was significantly associated with PTB (odds ratio (OR): 2.6, 95% confidence interval (CI): 1.31-5.17), and meta-analysis confirmed this association (OR: 2.71, 95% CI: 1.15-6.4).ConclusionReplication and meta-analysis support an increased risk of PTB in Caucasians with the fetal FVL mutation.Michael E. O’Callaghan, Alastair H. MacLennan, Gai L. McMichael, Eric A. Haan and Gustaaf A. Dekke
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