Two tone response of radiofrequency signals using the voltage output of a Superconducting Quantum Interference Filter

In the presence of weak time harmonic electromagnetic fields, Superconducting Quantum Interference Filters (SQIFs) show the typical behavior of non linear mixers. The SQIFs are manufactured from high-T_c grain boundary Josephson junctions and operated in active microcooler. The dependence of dc voltage output V_dc vs. static external magnetic field B is non-periodic and consists of a well pronounced unique dip at zero field, with marginal side modulations at higher fields. We have successfully exploited the parabolic shape of the voltage dip around B=0 to mix quadratically two external time harmonic rf-signals, at frequencies f_1 and f_2 below the Josephson frequency f_J, and detect the corresponding mixing signal at f_1-f_2. When the mixing takes place on the SQIF current-voltage characteristics the component at 2f_2 - f_1 is present. The experiments suggest potential applications of a SQIF as a non-linear mixing device, capable to operate at frequencies from dc to few GHz with a large dynamic range.Comment: 10 pages, 3 Figures, submitted to J. Supercond. (as proceeding of the HTSHFF Symposium, June 2006, Cardiff

Disorder Effects in Superconducting Multiple Loop Quantum Interferometers

A theoretical study is presented on a number N of resistively shunted Josephson junctions connected in parallel as a disordered 1D array by superconducting wiring in such a manner that there are N-1 individual SQUID loops with arbitrary shape formed.Comment: 4 pages, 2 figure

Fitness of Isogenic Colony Morphology Variants of Pseudomonas aeruginosa in Murine Airway Infection

Chronic lung infections with Pseudomonas aeruginosa are associated with the diversification of the persisting clone into niche specialists and morphotypes, a phenomenon called ‘dissociative behaviour’. To explore the potential of P. aeruginosa to change its morphotype by single step loss-of–function mutagenesis, a signature-tagged mini-Tn5 plasposon library of the cystic fibrosis airway isolate TBCF10839 was screened for colony morphology variants under nine different conditions in vitro. Transposon insertion into 1% of the genome changed colony morphology into eight discernable morphotypes. Half of the 55 targets encode features of primary or secondary metabolism whereby quinolone production was frequently affected. In the other half the transposon had inserted into genes of the functional categories transport, regulation or motility/chemotaxis. To mimic dissociative behaviour of isogenic strains in lungs, pools of 25 colony morphology variants were tested for competitive fitness in an acute murine airway infection model. Six of the 55 mutants either grew better or worse in vivo than in vitro, respectively. Metabolic proficiency of the colony morphology variant was a key determinant for survival in murine airways. The most common morphotype of self-destructive autolysis did unexpectedly not impair fitness. Transposon insertions into homologous genes of strain PAO1 did not reproduce the TBCF10839 mutant morphotypes for 16 of 19 examined loci pointing to an important role of the genetic background on colony morphology. Depending on the chosen P. aeruginosa strain, functional genome scans will explore other areas of the evolutionary landscape. Based on our discordant findings of mutant phenotypes in P. aeruginosa strains PAO1, PA14 and TBCF10839, we conclude that the current focus on few reference strains may miss modes of niche adaptation and dissociative behaviour that are relevant for the microevolution of complex traits in the wild

Latina and European American Girls’ Experiences with Academic Sexism and their Self-Concepts in Mathematics and Science During Adolescence

The study investigated Latina and European American adolescent girls’ (N = 345, M = 15.2 years, range = 13 to 18) experiences with academic sexism in mathematics and science (M/S) and their M/S perceived competence and M/S value (liking and importance). M/S academic sexism was based on girls’ reported experiences hearing sexist comments about girls’ abilities in math and science. Older European American adolescents, and both younger and older Latina adolescents, who experienced several instances of academic sexism felt less competent in M/S than girls who experienced less sexism (controlling for M/S grades). In addition, among older girls (regardless of ethnicity), those who experienced several instances of academic sexism valued M/S less than girls who experienced less sexism