250 research outputs found
Sparse Predictive Structure of Deconvolved Functional Brain Networks
The functional and structural representation of the brain as a complex
network is marked by the fact that the comparison of noisy and intrinsically
correlated high-dimensional structures between experimental conditions or
groups shuns typical mass univariate methods. Furthermore most network
estimation methods cannot distinguish between real and spurious correlation
arising from the convolution due to nodes' interaction, which thus introduces
additional noise in the data. We propose a machine learning pipeline aimed at
identifying multivariate differences between brain networks associated to
different experimental conditions. The pipeline (1) leverages the deconvolved
individual contribution of each edge and (2) maps the task into a sparse
classification problem in order to construct the associated "sparse deconvolved
predictive network", i.e., a graph with the same nodes of those compared but
whose edge weights are defined by their relevance for out of sample predictions
in classification. We present an application of the proposed method by decoding
the covert attention direction (left or right) based on the single-trial
functional connectivity matrix extracted from high-frequency
magnetoencephalography (MEG) data. Our results demonstrate how network
deconvolution matched with sparse classification methods outperforms typical
approaches for MEG decoding
A unifying view for performance measures in multi-class prediction
In the last few years, many different performance measures have been
introduced to overcome the weakness of the most natural metric, the Accuracy.
Among them, Matthews Correlation Coefficient has recently gained popularity
among researchers not only in machine learning but also in several application
fields such as bioinformatics. Nonetheless, further novel functions are being
proposed in literature. We show that Confusion Entropy, a recently introduced
classifier performance measure for multi-class problems, has a strong
(monotone) relation with the multi-class generalization of a classical metric,
the Matthews Correlation Coefficient. Computational evidence in support of the
claim is provided, together with an outline of the theoretical explanation
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