3 research outputs found
Molecular Dynamics Simulation of Vascular Network Formation
Endothelial cells are responsible for the formation of the capillary blood
vessel network. We describe a system of endothelial cells by means of
two-dimensional molecular dynamics simulations of point-like particles. Cells'
motion is governed by the gradient of the concentration of a chemical substance
that they produce (chemotaxis). The typical time of degradation of the chemical
substance introduces a characteristic length in the system. We show that
point-like model cells form network resembling structures tuned by this
characteristic length, before collapsing altogether. Successively, we improve
the non-realistic point-like model cells by introducing an isotropic strong
repulsive force between them and a velocity dependent force mimicking the
observed peculiarity of endothelial cells to preserve the direction of their
motion (persistence). This more realistic model does not show a clear network
formation. We ascribe this partial fault in reproducing the experiments to the
static geometry of our model cells that, in reality, change their shapes by
elongating toward neighboring cells.Comment: 10 pages, 3 figures, 2 of which composite with 8 pictures each.
Accepted on J.Stat.Mech. (2009). Appeared at the poster session of
StatPhys23, Genoa, Italy, July 13 (2007
Waves for an hyperbolic Keller-Segel model and branching instabilities
Recent experiments for swarming of the bacteria {\em Bacillus subtilis} on nutrient rich media show that these cells are able to proliferate and spread out in colonies exhibiting complex patterns as dendritic ramifications. Is it possible to explain this process with a model that does not use local nutrient depletion? We present a new class of models which is compatible with the experimental observations and which predict branching instabilities and does not use nutrient limitation. These conclusions are based on numerical simulations. The most complex of these models is also the biologically most accurate but the essential effects can also be obtained in simplified versions which are amenable to analysis. An example of instability mechanism is the transition from a shock wave to a rarefaction wave in a reduced two by two hyperbolic system