vaccination in a patient with Behcet's disease

Case report: A 25-year-old man with Behcet's disease was admitted because of weakness of the lower limbs and difficulty in urination. He had received a rabies vaccination 2 months previous because he had been bitten by a dog.Findings: Clinical and laboratory findings supported acute transverse myelitis. A hyperintense lesion and expansion at the level of conus medullaris was detected on spinal magnetic resonance imaging.Conclusion: Although neurologic involvement is one of the main causes of mortality and morbidity in Behcet's disease, the factors that aggravate the involvement of the nervous system are still unclear. Vaccination may have been the factor that had activated autoimmune mechanisms in this case. To our knowledge, involvement of the conus medullaris in Behcet's disease after rabies vaccination has not been reported

Comparison of conduction velocities of nerve fibers to smaller and larger muscles in rats

The aim of this study was to compare conduction velocities of motor fibers to smaller and larger muscles and to investigate the advantages and disadvantages of recordings from the gastrocnemius muscle with surface electrodes over the recordings from small foot muscles (interosseous muscles) with needle electrodes in rats. Surface and needle recordings are suitable in measuring the motor conduction velocity of the sciatic (tibial) nerve. It should be noted that the motor velocity measured from the gastrocnemius muscle is higher than the motor velocity elicited from small foot muscles. Surface recordings provide information on the amplitude and duration of M responses. © 2010 Informa Healthcare USA, Inc

Effect of hyperglycemia on conduction parameters of tibial nerve′s fibers to different muscles: A rat model

Introduction: Routine conduction studies reflect the summation of all nerve fibers in a peripheral nerve. Nerve fiber groups to distal, small muscles have smaller diameters than the ones to large proximal muscles. There may be minimal differences between the diameters of nerve fiber groups innervating different muscles; even they are all same type of fibers. So, in neuropathic processes some nerve fiber groups may be more seriously affected. Materials and Methods: 14 rats ( 7 diabetic, 7 control) were studied. Tibial nerve was stimulated from two points and while recorded from a distal (foot intrinsic muscles) and a proximal (gastrocnemius) muscle. Results: There was a significant difference between the proximal and distal recorded conduction velocities. Both proximal and distal recorded conduction velocities decreased during the hyperglycemic process. Discussion: Our method successfully demonstrated different nerve fiber groups; but, the neuropathic process seemed to be homogeneous in both fiber groups

Effect of hyperglycemia on conduction parameters of tibial nerve's fibers to different muscles: A rat model.

INTRODUCTION: Routine conduction studies reflect the summation of all nerve fibers in a peripheral nerve. Nerve fiber groups to distal, small muscles have smaller diameters than the ones to large proximal muscles. There may be minimal differences between the diameters of nerve fiber groups innervating different muscles; even they are all same type of fibers. So, in neuropathic processes some nerve fiber groups may be more seriously affected. MATERIALS AND METHODS: 14 rats ( 7 diabetic, 7 control) were studied. Tibial nerve was stimulated from two points and while recorded from a distal (foot intrinsic muscles) and a proximal (gastrocnemius) muscle. RESULTS: There was a significant difference between the proximal and distal recorded conduction velocities. Both proximal and distal recorded conduction velocities decreased during the hyperglycemic process. DISCUSSION: Our method successfully demonstrated different nerve fiber groups; but, the neuropathic process seemed to be homogeneous in both fiber groups

Comparison of conduction velocities of nerve fibers to smaller and larger muscles in rats.

The aim of this study was to compare conduction velocities of motor fibers to smaller and larger muscles and to investigate the advantages and disadvantages of recordings from the gastrocnemius muscle with surface electrodes over the recordings from small foot muscles (interosseous muscles) with needle electrodes in rats. Surface and needle recordings are suitable in measuring the motor conduction velocity of the sciatic (tibial) nerve. It should be noted that the motor velocity measured from the gastrocnemius muscle is higher than the motor velocity elicited from small foot muscles. Surface recordings provide information on the amplitude and duration of M responses

Larger Muscles in Rats

The aim of this study was to compare conduction velocities of motor fibers to smaller and larger muscles and to investigate the advantages and disadvantages of recordings from the gastrocnemius muscle with surface electrodes over the recordings from small foot muscles (interosseous muscles) with needle electrodes in rats. Surface and needle recordings are suitable in measuring the motor conduction velocity of the sciatic (tibial) nerve. It should be noted that the motor velocity measured from the gastrocnemius muscle is higher than the motor velocity elicited from small foot muscles. Surface recordings provide information on the amplitude and duration of M responses

Acute transverse myelitis at the conus medullaris level after rabies vaccination in a patient with Behçet's disease.

CASE REPORT: A 25-year-old man with Behçet's disease was admitted because of weakness of the lower limbs and difficulty in urination. He had received a rabies vaccination 2 months previous because he had been bitten by a dog. FINDINGS: Clinical and laboratory findings supported acute transverse myelitis. A hyperintense lesion and expansion at the level of conus medullaris was detected on spinal magnetic resonance imaging. CONCLUSION: Although neurologic involvement is one of the main causes of mortality and morbidity in Behçet's disease, the factors that aggravate the involvement of the nervous system are still unclear. Vaccination may have been the factor that had activated autoimmune mechanisms in this case. To our knowledge, involvement of the conus medullaris in Behçet's disease after rabies vaccination has not been reported

Association between cholesterols, homocysteine and silent brain infarcts

The aim of this study was to assess the relationship between total plasma homocysteine, cholesterol levels, vitamin B(12), folate, thyroid hormones, urea, ferritin, uric acid, C-reactive protein, cardiovascular risk factors and silent brain infarct (SBI) in patients without any neurological disorder. Whether the factors of interest were associated with SBI is investigated.One hundred and forty-two subjects with a mean age of 52.1 +/- 13.1 years (21-87 years) without any history of stroke, transient ischaemic attack and neurological abnormality were enrolled in this cross-sectional study. The subjects underwent brain magnetic resonance imaging and blood chemistry determinations. Student's t-test was used to compare differences in means of laboratory results between the groups with and without SBI. The chi(2)-test was used for categorized variables. Multiple logistic regression analysis was used to determine the independent predictors of SBI.The group comprised 56 men and 86 women. SBI were found in 40 patients (28%). The low-density lipoprotein levels were significantly higher in the infarct group (P = 0.019), homocysteine concentrations were significantly higher in the men-infarct group (P = 0,029) and total cholesterol levels were significantly higher in the women-infarct group than the women non-infarct group (P = 0.006).Serum low-density lipoprotein, total cholesterol and homocysteine levels were associated with SBI

Association between cholesterols, homocysteine and silent brain infarcts.

BACKGROUND: The aim of this study was to assess the relationship between total plasma homocysteine, cholesterol levels, vitamin B(12), folate, thyroid hormones, urea, ferritin, uric acid, C-reactive protein, cardiovascular risk factors and silent brain infarct (SBI) in patients without any neurological disorder. Whether the factors of interest were associated with SBI is investigated. METHODS: One hundred and forty-two subjects with a mean age of 52.1 +/- 13.1 years (21-87 years) without any history of stroke, transient ischaemic attack and neurological abnormality were enrolled in this cross-sectional study. The subjects underwent brain magnetic resonance imaging and blood chemistry determinations. Student's t-test was used to compare differences in means of laboratory results between the groups with and without SBI. The chi(2)-test was used for categorized variables. Multiple logistic regression analysis was used to determine the independent predictors of SBI. RESULTS: The group comprised 56 men and 86 women. SBI were found in 40 patients (28%). The low-density lipoprotein levels were significantly higher in the infarct group (P = 0.019), homocysteine concentrations were significantly higher in the men-infarct group (P = 0,029) and total cholesterol levels were significantly higher in the women-infarct group than the women non-infarct group (P = 0.006). CONCLUSION: Serum low-density lipoprotein, total cholesterol and homocysteine levels were associated with SBI