2 research outputs found
Effect of Nasopharyngeal Irrigation on Early Eustachian Tube Functions in Patients Undergoing Adenoidectomy: A Clinical Prospective Study
Objective:The hypertrophic adenoid tissue can cause to eustachian tube dysfunction by mechanical or inflammatory effect both of which block the nasopharyngeal ostium of the eustachian tube. Adenoidectomy, with or without tonsillectomy, is the most common surgical procedure in children. In this study, we aimed to investigate whether nasopharyngeal irrigation for hemorrhage control in adenoidectomy patients has an effect on eustachian tube functions.Method:Patients who underwent adenoidectomy for adenoid hypertrophy evaluated on both the preoperatively and on the postoperative first day by otomicroscopic examination and with tympanometry for eustachian tube functions. Patients were divided into two groups according to nasopharyngeal irrigation type after surgery. Group 1 was the transnasal pressure irrigation group; group 2 was transoral passive irrigation group. Tympanometry was used to measure pressure, volumetric, and compliance values to compare pre- and postoperative values.Results:40 patients were included in the study. There was no significant difference between the age and sex distributions of the patients. Volume and compliance values between the groups were similar before and after the surgery. The mean pressure values of the tympanometry parameters were highly significantly different for the right ear and moderately different for the left ear in group 1; were significantly different for the right ear and highly significantly different for the left ear in group 2. Postoperative tympanometry types were seen as bilateral type C in 7 patients, as right side type C in 4 patients, as bilateral type B in 2 patients, as left side type C in 4 patients in group 1. However, in group 2, right side type B, left side type B and bilateral type C tympanogram were observed in 1 patient, 2 patients and 12 patients, respectively.Conclusion:In this study, we observed that the nasopharyngeal irrigation to control bleeding after adenoidectomy had adverse effect on the eustachian tube functions but larger series of studies are needed to confirm this
Effects of oral sotretinoin on normal and wounded nasal mucosa: An experimental study
WOS: 000450099400016PubMed: 30382397BackgroundWe aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model.MethodsCircular mucosal defect with a 7mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group. The harvested septum mucosas were divided into four groups (1wounded-drug given side, 2unwounded and drug-given side, 3wounded-control and 4unwounded-control side). The diameter of the defect, mucosal thickness, epithelial thickness, ciliated cell level, goblet cell level and inflammation were evaluated every week for 4weeks.ResultsAt both wounded and normal side, thinning of normal respiratory ciliated epithelium was observed in the postoperative period. In study group at the wounded side; mean mucosal thickness was measured 139.66 mu (26.24), and in the control group, mean mucosal thickness was 238.33 mu (+/- 39.7) at the wounded side. (p<0.001). The difference between the groups in thickness of normal septal mucosa was also statistically significant (p=0.016) [190 mu (+/- 14.6) and 256.66 mu (+/- 44.66)]. The average cilia level was observed 1.16 in the wounded study group, while the average level was 2.33 in the wounded control group (p=0.012). Average score measurements of the regenerated mucosa suggested that isotretinoin-given wounded animals have reduced goblet cell recovery, compared to the control both on the regenerated and unwounded mucosas (p=0.007, p=0.002, respectively). Inflammation was significantly higher in the wounded isotretinoin group (p=0.018).Conclusion Oral isotretinoin has negative effects on epithelial and ciliary regeneration, significantly reduces mucosal thickness and goblet cell counts of the normal and regenerated mucosa, causes severe inflammation and significant reactive changes