1 research outputs found
Green Electrospun Poly(vinyl alcohol)/Gelatin-Based Nanofibrous Membrane by Incorporating 45S5 Bioglass Nanoparticles and Urea for Wound Dressing Applications: Characterization and In Vitro and In Vivo Evaluations
This study reports
the fabrication and characterization of poly(vinyl
alcohol) (PVA) and gelatin (Gel)-based nanofiber membranes cross-linked
with citric acid (CA) by a green electrospinning method in which nano
45S5 bioglass (BG) and urea were incorporated. Various combinations
of PVA, gelatin, and BG were prepared, and nanofiber membranes with
average fiber diameters between 238 and 595 nm were fabricated. Morphological,
chemical, and mechanical properties, porosity, swelling, water retention,
and water vapor transmission rate of the fabricated membranes were
evaluated. PVA:Gel (90:10), 15% CA, and 3% BG were determined as the
optimum blend for nanofiber membrane fabrication via electrospinning.
The membrane obtained using this blend was further functionalized
with 10% w/w polymer urea coating by the electrospray method following
the cross-linking. In vitro biocompatibility tests revealed that the
fabricated membranes were all biocompatible except for the one that
functionalized with urea. In vivo macroscopic and histopathological
analysis results of PVA/Gel/BG and PVA/Gel/BG/Urea treated wounds
indicated increased collagenization and vascularization and had an
anti-inflammatory effect. Furthermore, careful examination of the
in vivo macroscopic results of the PVA/Gel/BG/Urea membrane indicated
its potential to decrease uneven scar formation. In conclusion, developed
PVA/Gel/BG and PVA/Gel/BG/Urea electrospun membranes with multifunctional
and biomimetic features may have the potential to be used as beneficial
wound dressings