Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine

BACKGROUND: The small intestine is extremely sensitive to ischemia-reperfusion (I/R) injury and a range of microcirculatory disturbances which contribute to tissue damage. Previous studies have shown that leptin plays an important physiological role in the microvasculature. The aim of this study was to evaluate the protective effects of leptin in I/R – induced mucosal injury in the small intestine. METHODS: Forty rats were divided into 5 groups (n = 8). Group I was subjected to a sham operation. Following mesenteric ischemia in group II (control); physiologic saline 1 cm(3), in group III; leptin 100 μg/kg, and physiologic saline 1 cm(3), in group IV; N(G)-L-arginine methyl ester (L-NAME) 20 mg/kg, and physiologic saline 1 cm(3), in group V; leptin 100 μg/kg, L-NAME 20 mg/kg, and physiologic saline 1 cm(3 )were given intra-peritoneally. In these groups, an I/R procedure was performed by occlusion of the superior mesenteric artery for 45 min followed by 120 min reperfusion. After reperfusion, the small intestines were resected for malondialdehyde (MDA) and nitric oxide (NO) concentration and histopathologic properties. Mucosal lesions were scored between 0 and 5. Tissue MDA and NO concentration and histopathologic grades were compared statistically. RESULTS: Tissue MDA level significantly increased (P < 0.05), tissue NO level significantly decreased in group V animals, compared to group III animals respectively (P < 0.001). Histopathologically, intestinal injury significantly decreased in the leptin treated ischemic group. CONCLUSION: Leptin can be used safely in mesenteric occlusive diseases, since it induces NO formation and release in mesenteric vessels

Karaciğer kist hidatiğine laparoskopik cerrahi yaklaşım: Retrospektif çalışma

Karaciğer kist hidatiğinin tedavisinde laparoskopik yaklaşım, giderek önem kazanmakla birlikte, uzun dönem sonuçları alınmadığından halen tartışılmaktadır. Bu yazıda, kliniğimizde 1997-2002 yılları arasında laparoskopik cerrahi uyguladığımız 14 karaciğer kist hidatik olgusunu retrospektif olarak değerlendirdik. Sonuç olarak; karaciğer kist hidatiğinin cerrahi tedavisinde laparoskopik drenaj ve marsupiyalizasyonun oldukça güvenli ve etkin bir yöntem olduğu sonucuna ulaştık.However laparoscopic approach to treatment of hydatid cyst of liver gets more important increasingly, it's stili equivocal since long-term results have not been reported. in the present report, we evaluated 14 liver hidatid cyst cases that we treated with laparoscopic surgery between 1997 and 2002 years. As a result, we found that laparoscopic drainage and marsupalization is a fairly safe and effective method for surgical treatment of cyst hidatid of liver

Esophagectomy in esophageal lipoma: Report of a case

Lipoma is an uncommon benign tumor of the alimentary tract and its overall incidence is 4.1%, but that of the esophagus is extremely rare, with an incidence of only 0.4%. We present a case of esophageal lipoma. A 55-year-old man had a two-year history of dysphagia and odynophagia. Upper gastrointestinal system endoscopy showed a mass in the wall of the esophagus, occupying the lumen, and causing obstruction. Computed tomography and abdominal ultrasonography were performed because of endoscopic suspicion of submucosal tumor, and the mass was confirmed to be a lipoma in the wall of the esophagus. It was removed surgically by a thoracic approach. His symptoms resolved after the operation. Surgical excision by enucleation of the tumor is the preferred treatment of esophageal lipoma, but opening of the esophageal mucosa during this procedure is a rare cause for esophageal resection