Squamous cell carcinoma arising from teratoma of the ovary: magnetic resonance, computed tomography, and pathological findings

WOS: 000396648700029PubMed: 29767884In the present case report, the authors investigated the clinicopathological characteristics of squamous cell carcinoma (SCC) arising from teratoma of the ovary and intended to report their clinical experience. Malignant transformation of ovarian teratoma is a quite rare condition with SCC observed to be the most common form of transformation. the present case was a 43-year-old female patient and her clinical presentation was abdominal pain, abdominal distension, and abdominal mass sensation. the patient underwent ultrasonography. After detection of a mass, magnetic resonance imaging (MRI) was performed. Surgery was performed on the patient and the pathological report revealed SCC arising from teratoma. the patient was evaluated retrospectively in terms of demographic characteristics, MRI, surgical findings, and prognosis

The effect of gadolinium-based contrast agents on rat testis

Mercantepe, Tolga/0000-0002-8506-1755; INECIKLI, MEHMET FATIH/0000-0002-9796-8223; yilmaz, adnan/0000-0003-4842-1173; TUMKAYA, Levent/0000-0002-2814-5194WOS: 000438889600019PubMed: 29700836Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. the purpose of this prospective animal study was to investigate the effect of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCAs) on rat testis tissue and to compare these molecules in terms of tissue damage. Thirty-two male Sprague-Dawley rats were kept without drugs for 5weeks after administration of 0.1mmol mg(-1) kg(-1) (0.2ml/kg) gadodiamide and gadoteric acid for 4days over 5weeks. Biochemical, histopathological and immunohistochemical changes in testis tissue were evaluated at the end of 10weeks. When used in repeated clinical doses, gadolinium was observed to increase apoptosis in the Leydig cells of the rat testis, and to increase serum Ca+2 levels and reduce testosterone levels (p.05). Both linear and macrocyclic contrast agents have toxic effects on testis tissue, irrespective of the type of drug.Recep Tayyip Erdogan University Scientific Research Projects Coordination UnitRecep Tayyip Erdogan University [TSA-2016-559]We confirm that all of the materials needed for this experimental study was derived from Recep Tayyip Erdogan University Scientific Research Projects Coordination Unit (code: TSA-2016-559)

The effect of gadolinium-based contrast agents on rat testis

PMID = 2970083