Analysis of temporal changes in visual function using Ganzfeld ERG.

<p><b>A-C.</b> Graphs show representative curves of Ganzfeld ERG during the experimental time-course of a (A) sham, (B) late affected BCCAO and (C) early affected BCCAO animals. <b>D.</b> Scotopic a-wave. <b>E.</b> Scotopic b-wave. <b>F.</b> b/a-wave ratio. <b>G.</b> Oscillatory potentials.</p

Delocalization of synaptic markers in the retina after BCCAO.

<p><b>A.</b> Representative sagittal sections of the retina stained against VGLUT1 (green) showing loss and delocalization of pre-synaptic proteins in animals with BCCAO. <b>B.</b> Representative sagittal sections of the retina stained against CTBP2 (red) showing loss and delocalization of pre-synaptic proteins. <b>C.</b> Representative sagittal sections of the retina stained against PKCα (green) showing loss and delocalization of post-synaptic proteins after prolonged BCCAO. <b>D.</b> Representative sagittal sections of the retina stained against CALB (red) showing loss horizontal cells in coiled animals. All nuclei were counterstained with DAPI (blue). For all cases, scale bar = 50.</p

Primer sequences.

<p>Primer sequences.</p

Exclusion criteria to reduce bias.

<p>Exclusion criteria to reduce bias.</p

Inflammatory dynamics in the retina after BCCAO.

<p><b>A.</b> Time-course of fundus auto-fluorescence of MacGreen mouse after BCCAO. EGFP signal corresponds to myeloid cells. Marked regions (dashed lines in red) show clusters of mononuclear phagocytes. <b>B.</b> Bar charts represent differential RNA expression of inflammatory markers of retinal tissue.</p

Vascular dynamics in the retina after BCCAO.

<p><b>A.</b> Time-course of fundus angiographies after BCCAO (A) or sham intervention (B). Arrows point to (dilated) veins. <b>C.</b> Left: Representative fundus angiographies depicting arteries (A) and veins (V). Right: Bar chart represents the V-A ratio of the distinct groups (BCCAO vs. sham) during the time-course. <b>D-H.</b> Bar charts represent differential RNA expression of angiogenic markers in retinal tissue.</p

Secondary antibodies.

<p>Secondary antibodies.</p

SKAT TEST.

<p>SKAT TEST.</p

Most significant variants.

<p>Most significant variants.</p