The convergent structural base of sustainable development in the 21st century

Sustainable development is a symbiosis of technological and social progress, as well as responsible environmental management, should not rely on old industries that actively consume non-renewable natural resources, but on new, convergent-technological ones. In this paradigm, the environmental safety of future generations is formed by structural shifts in the economies of advanced countries caused by the expansion of technological convergence. Technological convergence – the result of accelerating scientific and technological progress in the 21st century – has a transformative effect on the economies of developed countries, forming a new type of sectorial genesis. It is not related to the deepening of sectorial specialization or inter-industry cooperation within the framework of the evolution of basic technologies, but to the emergence of technologies of a fundamentally new type, formed as a result of the merger of know-how from different industries. The structural shifts arising from technological convergence do not have the historical analogues and forms of regulation developed by industrial policies of developed countries. The article outlines the key statements of the the impact of convergent technologies on the structural base of sustainable development

Analiza możliwości udostępnienia nowego obszaru wybierania w północnej części zagłębia węgla brunatnego Sibovc w Kosowie

This review describes the possibility of development a new lignite deposit in northern Kosovo lignite basin - Sibovc. Analysis of the initial state briefly evaluates Kosovo energy sector, geomorphological conditions and quality of lignite from Sibovc deposit. With using Dataminesoft it was created geological model and approximate calculation of lignite reserves in the deposit. The data obtained from Dataminesoft were used as starting points of the financial analysis of project. The result of the analysis is exactly describe the qualitative and quantitative characteristics of deposit Sibovc compared to other deposits in the area and creating of geological model with productive horizons deposit of lignite. Based on these data lignite deposit Sibovc was classified, according to the classification of deposits the UN, as economical.W pracy tej omówiono możliwości udostępnienia nowego obszaru wybierania złoża węgla brunatnego (lignitu) w północnej części zagłębia węgla brunatnego Sibovc w Kosowie. W analizie stanu początkowego krótko scharakteryzowano sektor energetyczny Kosowa, warunki geo-morfologiczne oraz parametry jakościowe węgla brunatnego z zagłębia Sibovc. Przy pomocy pakietu Dataminesoft stworzono model geologiczny i przeprowadzono przybliżone obliczenia zasobów węgla brunatnego w złożu. Dane uzyskane przy zastosowaniu pakietu Dataminesoft zostały następnie wykorzystane jako dane wejściowe do analizy finansowej przedsięwzięcia. Na podstawie wyników analizy uzyskuje się jakościową i ilościową charakterystykę złoża w odniesieniu do pozostałych złóż w regionie. Opracowano model geologiczny ze szczegółowym wskazaniem poziomów wybierania lignitu. W oparciu o te dane dokonano klasyfikacji złoża węgla brunatnego (lignitu) w Sibovc zgodnie z międzynarodowymi zasadami klasyfikacji wykazując, że złoże będzie ekonomiczne

The Model of Direct Dumping Technology Implementation for Open Pit Coal Mining by High Benches

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала

Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments

The Alzheimer's disease-associated protein tau is an intrinsically disordered protein with no preferred structure in solution. Under physiological conditions, tau binds to microtubules and regulates their dynamics, whereas during the development of neurodegeneration tau dissociates from microtubules, misfolds and creates highly insoluble deposits. To elucidate the determinants of tau-protein misfolding, tau peptides from microtubule-binding motifs were crystallized in complexes with Fab fragments of specific monoclonal antibodies. The crystals diffracted to 1.69 Å resolution and gave complete data sets using a synchrotron X-ray source. Molecular replacement was used to solve the phase problem

Current and emerging avenues for Alzheimer's disease drug targets

Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a global epidemic and so far, there is no cure nor treatment to alter its progression. The most important feature of the disease is neuronal death and loss of cognitive functions, caused probably from several pathological processes in the brain. The main neuropathological features of AD are widely described: amyloid beta (Aβ) plaques and neurofibrillary tangles of the aggregated protein tau, which contribute to the disease. Nevertheless, AD brains suffer from a variety of alterations in function, such as energy metabolism, inflammation, and synaptic activity. The latest decades have seen an explosion of genes and molecules that can be employed as targets aiming to improve brain physiology, which can result in preventive strategies for AD. Moreover, therapeutics using these targets can help AD brains to sustain function during the development of AD pathology. Here, we review broadly recent information for potential targets that can modify AD through diverse pharmacological and non‐pharmacological approaches including gene therapy. We propose that AD could be tackled using combination therapies including Aβ and tau, but also considering insulin and cholesterol metabolism, vascular function, synaptic plasticity, epigenetics, neurovascular junction and blood‐brain barrier targets that have been studied recently. We also make a case for the role of gut microbiota in AD. Our hope is to promote the continuing research of diverse targets affecting AD and promote diverse targeting as a near‐future strategy