Simultaneous transmission and reception on all elements of an array: binary code excitation

Pulse-echo arrays are used in radar, sonar, seismic, medical and non-destructive evaluation. There is a trend to produce arrays with an ever-increasing number of elements. This trend presents two major challenges: (i) often the size of the elements is reduced resulting in a lower signal-to-noise ratio (SNR) and (ii) the time required to record all of the signals that correspond to every transmit–receive path increases. Coded sequences with good autocorrelation properties can increase the SNR while orthogonal sets can be used to simultaneously acquire all of the signals that correspond to every transmit–receive path. However, a central problem of conventional coded sequences is that they cannot achieve good autocorrelation and orthogonality properties simultaneously due to their length being limited by the location of the closest reflectors. In this paper, a solution to this problem is presented by using coded sequences that have receive intervals. The proposed approach can be more than one order of magnitude faster than conventional methods. In addition, binary excitation and quantization can be employed, which reduces the data throughput by roughly an order of magnitude and allows for higher sampling rates. While this concept is generally applicable to any field, a 16-element system was built to experimentally demonstrate this principle for the first time using a conventional medical ultrasound probe

A geometrical origin for the covariant entropy bound

Causal diamond-shaped subsets of space-time are naturally associated with operator algebras in quantum field theory, and they are also related to the Bousso covariant entropy bound. In this work we argue that the net of these causal sets to which are assigned the local operator algebras of quantum theories should be taken to be non orthomodular if there is some lowest scale for the description of space-time as a manifold. This geometry can be related to a reduction in the degrees of freedom of the holographic type under certain natural conditions for the local algebras. A non orthomodular net of causal sets that implements the cutoff in a covariant manner is constructed. It gives an explanation, in a simple example, of the non positive expansion condition for light-sheet selection in the covariant entropy bound. It also suggests a different covariant formulation of entropy bound.Comment: 20 pages, 8 figures, final versio

The effect of adjusting LDL-cholesterol for Lp(a)-cholesterol on the diagnosis of familial hypercholesterolaemia

BACKGROUND: Familial hypercholesterolaemia (FH) diagnostic tools help prioritise patients for genetic testing and include LDL-C estimates commonly calculated using the Friedewald equation. However, cholesterol contributions from lipoprotein(a) (Lp(a)) can overestimate 'true' LDL-C, leading to potentially inappropriate clinical FH diagnosis. OBJECTIVE: To assess how adjusting LDL-C for Lp(a)-cholesterol affects FH diagnoses using Simon Broome (SB) and Dutch Lipid Clinic Network (DLCN) criteria. METHODS: Adults referred to a tertiary lipid clinic in London, UK were included if they had undergone FH genetic testing based on SB or DLCN criteria. LDL-C was adjusted for Lp(a)-cholesterol using estimated cholesterol contents of 17.3%, 30% and 45%, and the effects of these adjustments on reclassification to 'unlikely' FH and diagnostic accuracy were determined. RESULTS: Depending on the estimated cholesterol content applied, LDL-C adjustment reclassified 8-23% and 6-17% of patients to 'unlikely' FH using SB and DLCN criteria, respectively. The highest reclassification rates were observed following 45% adjustment in mutation-negative patients with higher Lp(a) levels. This led to an improvement in diagnostic accuracy (46% to 57% with SB, and 32% to 44% with DLCN following 45% adjustment) through increased specificity. However all adjustment factors led to erroneous reclassification of mutation-positive patients to 'unlikely' FH. CONCLUSION: LDL-C adjustment for Lp(a)-cholesterol improves the accuracy of clinical FH diagnostic tools. Adopting this approach would reduce unnecessary genetic testing but also incorrectly reclassify mutation-positive patients. Health economic analysis is needed to balance the risks of over- and under-diagnosis before LDL-C adjustments for Lp(a) can be recommended

Shear waves with orthogonal polarisations for thickness measurement and crack detection using EMATs

The use of polarised shear waves to detect the presence of crack-like defects seems to have received little or no attention in the past. The authors believe that the main reason for this appears to be the lack of a device with the capability to excite shear waves of different polarisations. In this paper, the authors, first, present the design of an EMAT that permits the excitation of two orthogonally polarised shear waves in metallic materials by means of two coils that are orthogonal with respect to each other. This is then followed by a 3D finite element analysis of the wavefield generated by the EMAT and its interactions with crack-like defects of different sizes, positions and orientations. Then a methodology of how this EMAT can be used to simultaneously measure material thickness and detect crack-like defects in pulse-echo mode is introduced. Good agreement between the finite element simulation and experimental results was observed which makes the presented technique a potential new method for simultaneous thickness measurements and crack detection

Orthogonally polarised shear waves for evaluating anisotropy and cracks in metals

The detection of crack-like defects using ultrasound is a problem widely studied by the non-destructive evaluation community. In this work, a technique of how to detect the presence of a crack-like defect and estimate its orientation in an anisotropic material by means of two orthogonal shear waves is presented. A detailed study of shear wave propagating and splitting at any incident angle, and its interaction with crack-like defects in anisotropic materials, is also presented. In this paper it is shown that by the use of two orthogonal shear waves with linear polarisation the authors could: 1) estimate the material level of anisotropy within approximately 0.5% of the measured value; 2) estimate the angular position of the principal shear directions of the material with respect to the orthogonal shear wave sources within ±5⁰ accuracy; 3) excite a shear wave purely polarised along one of the principal shear directions with two orthogonal shear waves placed at an arbitrary angular position; 4) detect the presence of a crack-like defect in an anisotropic material based on the back-wall echoes of two orthogonal shear waves, 5) estimate the orientation of a crack-like defect in an anisotropic material within ∼ ± 5⁰ of the theoretical value. The simulation and experimental results obtained show that the technique presented in this paper has potential to become an effective tool for crack-like defect detection and material characterisation

RAMP2 influences glucagon receptor pharmacology via trafficking and signaling

Endogenous satiety hormones provide an attractive target for obesity drugs. Glucagon causes weight loss by reducing food intake and increasing energy expenditure. To further understand the cellular mechanisms by which glucagon and related ligands activate the glucagon receptor (GCGR), we investigated the interaction of the GCGR with receptor activity modifying protein (RAMP)2, a member of the family of receptor activity modifying proteins. We used a combination of competition binding experiments, cell surface enzyme-linked immunosorbent assay, functional assays assessing the Gαs and Gαq pathways and β-arrestin recruitment, and small interfering RNA knockdown to examine the effect of RAMP2 on the GCGR. Ligands tested were glucagon; glucagonlike peptide-1 (GLP-1); oxyntomodulin; and analog G(X), a GLP-1/glucagon coagonist developed in-house. Confocal microscopy was used to assess whether RAMP2 affects the subcellular distribution of GCGR. Here we demonstrate that coexpression of RAMP2 and the GCGR results in reduced cell surface expression of the GCGR. This was confirmed by confocal microscopy, which demonstrated that RAMP2 colocalizes with the GCGR and causes significant GCGR cellular redistribution. Furthermore, the presence of RAMP2 influences signaling through the Gαs and Gαq pathways, as well as recruitment of β-arrestin. This work suggests that RAMP2 may modify the agonist activity and trafficking of the GCGR, with potential relevance to production of new peptide analogs with selective agonist activities

Orbital misalignment of the super-Earth π\pi Men c with the spin of its star

Planet-planet scattering events can leave an observable trace of a planet's migration history in the form of orbital misalignment with respect to the the stellar spin axis, which is measurable from spectroscopic timeseries taken during transit. We present high-resolution spectroscopic transits observed with ESPRESSO of the close-in super-Earth $\pi$ Men c. The system also contains an outer giant planet on a wide, eccentric orbit, recently found to be inclined with respect to the inner planetary orbit. These characteristics are reminiscent of past dynamical interactions. We successfully retrieve the planet-occulted light during transit and find evidence that the orbit of $\pi$ Men c is moderately misaligned with the stellar spin axis with $\lambda = -24.0^\circ \pm 4.1^\circ$ ($\psi = 26.9^{\circ +5.8^\circ}_{\,-4.7^\circ}$). This is consistent with the super-Earth $\pi$ Men c having followed a high-eccentricity migration followed by tidal circularisation, and hints that super-Earths can form at large distances from their star. We also detect clear signatures of solar-like oscillations within our ESPRESSO radial velocity timeseries, where we reach a radial velocity precision of ${\sim}20$ cm/s. We model the oscillations using Gaussian processes and retrieve a frequency of maximum oscillation, $\nu_\text{max} = 2771^{+65}_{-60}$ $\mu$Hz. These oscillations makes it challenging to detect the Rossiter-McLaughlin effect using traditional methods. We are, however, successful using the reloaded Rossiter-McLaughlin approach. Finally, in an appendix we also present updated physical parameters and ephemerides for $\pi$ Men c from a Gaussian process transit analysis of the full TESS Cycle 1 data.Comment: 20 pages, 11 figures. Published in MNRA

A transiting companion to the eclipsing binary KIC002856960

We present an early result from an automated search of Kepler eclipsing binary systems for circumbinary companions. An intriguing tertiary signal has been discovered in the short period eclipsing binary KIC002856960. This third body leads to transit-like features in the light curve occurring every 204.2 days, while the two other components of the system display eclipses on a 6.2 hour period. The variations due to the tertiary body last for a duration of \sim1.26 days, or 4.9 binary orbital periods. During each crossing of the binary orbit with the tertiary body, multiple individual transits are observed as the close binary stars repeatedly move in and out of alignment with the tertiary object. We are at this stage unable to distinguish between a planetary companion to a close eclipsing binary, or a hierarchical triply eclipsing system of three stars. Both possibilities are explored, and the light curves presented.Comment: Accepted into A&A Letters (5 pages & 3 figures

Geometric entropy, area, and strong subadditivity

The trace over the degrees of freedom located in a subset of the space transforms the vacuum state into a density matrix with non zero entropy. This geometric entropy is believed to be deeply related to the entropy of black holes. Indeed, previous calculations in the context of quantum field theory, where the result is actually ultraviolet divergent, have shown that the geometric entropy is proportional to the area for a very special type of subsets. In this work we show that the area law follows in general from simple considerations based on quantum mechanics and relativity. An essential ingredient of our approach is the strong subadditive property of the quantum mechanical entropy.Comment: Published versio