52 research outputs found
Differential and double-differential dielectric spectroscopy to measure complex permittivity in transmission lines
Dielectric spectroscopy by differential measurements in trasmission lines on sodium dodecyl sulfate micelles in water
Adipocitoquinas y síndrome metabólico : rol de la vistafina en la patogenia de enfermedad cardiovascular
La enfermedad cardiovascular es la primera causa de morbi-mortalidad en los países industrializados. El síndrome metabólico, caracterizado por hipertensión, dislipidemia, obesidad e hiperglucemia, constituye el principal factor de riesgo para la enfermedad cardiovascular. El tejido adiposo visceral juega un papel fundamental en este proceso, dado que secreta una variedad de sustancias biológicamente activas denominadas adipoquinas o adipocitoquinas, tales como leptina, resistina, adiponectina, factor de necrosis tumoral alfa (TNFa), y visfatina entre otras. La visfatina es una citoquina descubierta recientemente y su rol en la enfermedad cardiovascular es controversial y aún no ha sido completamente dilucidado. Estudios realizados en humanos y en modelos experimentales en animales sugieren que la visfatina tendría un papel muy importante en las patologías asociadas a la enfermedad cardiovascular. Esta revisión intenta mostrar los últimos avances sobre el rol de la visfatina y las principales adipocitoquinas en las patologías cardiovasculares y el síndrome metabólico.Cardiovascular disease is the leading cause of mortality in western countries.
Metabolic syndrome (MS), characterized by hyperlipidemia, hypertension, obesity and hyperglycemia, is a significant risk factor for cardiovascular disease. Visceral adipose tissue play a key role in the development of metabolic syndrome since this tissue secrets a variety of bioactive substances named adipokines or adipocytokines such as leptin, resistin, adiponectin, tumor necrosis factor alfa (TNFa), and visfatin. Visfatin has been described recently and its role in cardiovascular disease is controversial and has not yet been fully elucidated. Studies in human and animal experimental models suggest that visfatin would have a key role in the pathologies associates with cardiovascular disease. This review is focused in the role of visfatin as well as the main dipocytokines with cardiovascular disease and metabolic syndrome.Fil: Rodríguez Lanzi, María Cecilia.
Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área de Fisiología PatológicaFil: Miatello, Roberto.
Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área de Fisiología PatológicaFil: Vazquez-Prieto, Marcela Alejandra.
Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área de Fisiología Patológic
Dietary (-)-epicatechin affects NF-kB activation and NADPH-oxidases in the kidney cortex of high fructose-fed rats
Inflammation involves the activation of redox-sensitive transcription factors, e.g. nuclear factor kB (NF-kB). Administration of (-)-epicatechin to high fructose-fed rats prevented NF-kB activation, and up-regulation of the NADPH oxidase 4 (NOX4) in kidney cortex. These results add mechanistic insight into the action of (-)-epicatechin diminishing inflammatory responses.Fil: Prince, Paula Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Rodríguez Lanzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Galleano, Mónica Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentin
DYSPHORIA DIMENSIONAL MODEL FOR FEEDING AND EATING DISORDERS: A PRELIMINARY STUDY
Background: Anorexia Nervosa (AN), Bulimia Nervosa (BN) and Binge Eating Disorder (BED) are severe psychiatric illnesses
which represent the main expression of Feeding and Eating Disorders (FED). Clinicians agree that emotional and behavioural
dysregulation play a crucial role in FED. Dysphoria could help us to better understand these components. Indeed, we define
dysphoria as a generic state of dissatisfaction and emotional instability, without any specific features. Among the multitude of
symptoms, we find that irritability, discontent, interpersonal resentment and surrender prevail. These dimensions correspond to the
four subscales of Neapean Dysphoria Scale - Italian version (NDS-I). Dysphoria role in FED has not yet been investigated. Using
this test, we can characterize dysphoria both in quantitative and qualitative terms. Accordingly, domain evaluation could
discriminate these disorders allowing us to assess possible differential phenomenological expressions.
Aims: The aim of this paper is to understand in which way the dimensional spectrum that composes dysphoria differs between
Anorexia Nervosa, Bulimia Nervosa and Binge Eating Disorders through an observational comparative study.
Subjects and methods: The enrolled sample (30 patients) is represented by patients with a history of FED (AN, BN or BED).
Patients were males and females between the ages of 13 and 45 with a good knowledge of Italian language. Patients with severe
cognitive impairment (MMSE <19) and civil incapacitation were excluded. Patients were recruited from the Psychiatric Service of
the Santa Maria della Misericordia Hospital in Perugia (PG), and other residential and semi residential structures specialized in
FED treatment (FED specialized center at Palazzo Francisci in Todi (PG), Nido delle Rondini in Todi (PG), BED (Binge Eating
Disorders) center in Città della Pieve (PG) and ambulatory services for FED in Umbertide (PG)). We administered them the Neapen
Dysphoria Scale – Italian Version (NDS-I), a specific dimensional test for dysphoria. Starting from the dataset, with the aid of the
statistical program SPSS 20, we have carried out a comparison between disorders groups selected and NDS-I total score and
subscales (irritability, discontent, interpersonal resentment, surrender). For this we have used the Mann-Whitney U test, a
nonparametric test with 2 independent samples, by setting a significance level p<0.05.
Conclusions: This study allowed us to better understand and characterize the most common Eating Disorders. Beyond that,
despite the small sample size, we found in our analysis statistically significant difference in the expression of various dysphoria
dimension spectrum inside our 3 groups
Study by Small-Angle Neutron Scattering of sodium dodecyl sulfate micelles with the macrocyclic ligand [2.2.2.]-cryptand
DYSPHORIA DIMENSIONAL MODEL FOR FEEDING AND EATING DISORDERS: A PRELIMINARY STUDY
Background: Anorexia Nervosa (AN), Bulimia Nervosa (BN) and Binge Eating Disorder (BED) are severe psychiatric illnesses
which represent the main expression of Feeding and Eating Disorders (FED). Clinicians agree that emotional and behavioural
dysregulation play a crucial role in FED. Dysphoria could help us to better understand these components. Indeed, we define
dysphoria as a generic state of dissatisfaction and emotional instability, without any specific features. Among the multitude of
symptoms, we find that irritability, discontent, interpersonal resentment and surrender prevail. These dimensions correspond to the
four subscales of Neapean Dysphoria Scale - Italian version (NDS-I). Dysphoria role in FED has not yet been investigated. Using
this test, we can characterize dysphoria both in quantitative and qualitative terms. Accordingly, domain evaluation could
discriminate these disorders allowing us to assess possible differential phenomenological expressions.
Aims: The aim of this paper is to understand in which way the dimensional spectrum that composes dysphoria differs between
Anorexia Nervosa, Bulimia Nervosa and Binge Eating Disorders through an observational comparative study.
Subjects and methods: The enrolled sample (30 patients) is represented by patients with a history of FED (AN, BN or BED).
Patients were males and females between the ages of 13 and 45 with a good knowledge of Italian language. Patients with severe
cognitive impairment (MMSE <19) and civil incapacitation were excluded. Patients were recruited from the Psychiatric Service of
the Santa Maria della Misericordia Hospital in Perugia (PG), and other residential and semi residential structures specialized in
FED treatment (FED specialized center at Palazzo Francisci in Todi (PG), Nido delle Rondini in Todi (PG), BED (Binge Eating
Disorders) center in Città della Pieve (PG) and ambulatory services for FED in Umbertide (PG)). We administered them the Neapen
Dysphoria Scale – Italian Version (NDS-I), a specific dimensional test for dysphoria. Starting from the dataset, with the aid of the
statistical program SPSS 20, we have carried out a comparison between disorders groups selected and NDS-I total score and
subscales (irritability, discontent, interpersonal resentment, surrender). For this we have used the Mann-Whitney U test, a
nonparametric test with 2 independent samples, by setting a significance level p<0.05.
Conclusions: This study allowed us to better understand and characterize the most common Eating Disorders. Beyond that,
despite the small sample size, we found in our analysis statistically significant difference in the expression of various dysphoria
dimension spectrum inside our 3 groups
Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats
This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables
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