The association of parental genetic, lifestyle, and social determinants of health with offspring overweight

In the UK, the number of comorbidities seen in children has increased along with the worsening obesity rate. These comorbidities worsen into adulthood. Genomewide association studies have highlighted single nucleotide polymorphisms associated with the weight status of adults and offspring individually. To date, in the UK, parental genetic, lifestyle, and social determinants of health have not been investigated alongside one another as influencers of offspring weight status. A comprehensive obesity prevention scheme would commence prior to conception and involve parental intervention including all known risk factors. This current study aims to identify the proportion of overweight that can be explained by known parental risk factors, including genetic, lifestyle, and social determinants of health with offspring weight status in the UK. Methods: A crosssectional study was carried out on 123 parents. Parental and offspring anthropometric data and parental lifestyle and social determinants of health data were self-reported. Parental genetic data were collected by use of GeneFiX saliva collection vials and genotype were assessed for brain-derived neurotrophic factor (BDNF) gene rs6265, melanocortin 4 receptor (MC4R) gene rs17782313, transmembrane protein 18 (TMEM18) gene rs2867125, and serine/threonine-protein kinase (TNN13K) gene rs1514175. Associations were assessed between parental data and the weight status of offspring. Results: Maternal body mass index modestly predicted child weight status (p < 0.015; R2 = 0.15). More mothers of overweight children carried the MC4R rs17782313 risk allele (77.8%; p = 0.007) compared to mothers of normal-weight children. Additionally, fathers who were not Caucasian and parents who slept for < 7 h/night had a larger percentage of overweight children when compared to their counterparts (p = 0.039; p = 0.014, respectively). Conclusion: Associations exist between the weight status of offspring based solely on parental genetic, lifestyle, and social determinants of health data. Further research is required to appropriately address future interventions based on genetic and lifestyle risk groups on a pre-parent cohort

Production and relevance of cosmogenic radionuclides in NaI(Tl) crystals

The cosmogenic production of long-lived radioactive isotopes in materials is an hazard for experiments demanding ultra-low background conditions. Although NaI(Tl) scintillators have been used in this context for a long time, very few activation data were available. We present results from two 12.5 kg NaI(Tl) detectors, developed within the ANAIS project and installed at the Canfranc Underground Laboratory. The prompt data taking starting made possible a reliable quantification of production of some I, Te and Na isotopes with half-lives larger than ten days. Initial activities underground were measured and then production rates at sea level were estimated following the history of detectors; a comparison of these rates with calculations using typical cosmic neutron flux at sea level and a selected description of excitation functions was also carried out. After including the contribution from the identified cosmogenic products in the detector background model, we found that the presence of 3H in the crystal bulk would help to fit much better our background model and experimental data. We have analyzed the cosmogenic production of 3H in NaI, and although precise quantification has not been attempted, we can conclude that it could imply a very relevant contribution to the total background below 15 keV in NaI detectors.Comment: Proceedings of the Low Radioactivity Techniques 2015 workshop, March 2015, Seattle (US

Status of the ANAIS Dark Matter Project at the Canfranc Underground Laboratory

The ANAIS experiment aims at the confirmation of the DAMA/LIBRA signal. A detailed analysis of two NaI(Tl) crystals of 12.5 kg each grown by Alpha Spectra will be shown: effective threshold at 1 keVee is at reach thanks to outstanding light collection and robust PMT noise filtering protocols and the measured background is well understood down to 3 keVee, having quantified K, U and Th content and cosmogenic activation in the crystals. A new detector was installed in Canfranc in March 2015 together with the two previous modules and preliminary characterization results will be presented. Finally, the status and expected sensitivity of the full experiment with 112 kg will be reviewed.Comment: Contributed to the 11th Patras Workshop on Axions, WIMPs and WISPs, Zaragoza, June 22 to 26, 201

Background model of NaI(Tl) detectors for the ANAIS Dark Matter Project

A thorough understanding of the background sources is mandatory in any experiment searching for rare events. The ANAIS (Annual Modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal at the Canfranc Underground Laboratory (LSC). Two NaI(Tl) crystals of 12.5 kg each produced by Alpha Spectra have been taking data since December 2012. The complete background model of these detectors and more precisely in the region of interest will be described. Preliminary background analysis of a new 12.5 kg crystal received at Canfranc in March 2015 will be presented too. Finally, the power of anticoincidence rejection in the region of interest has been analyzed in a 4x 5 12.5 kg detector matrix.Comment: Contributed to the 11th Patras Workshop on Axions, WIMPs and WISPs, Zaragoza, June 22 to 26, 201

Pulse Shape Analysis with scintillating bolometers

Among the detectors used for rare event searches, such as neutrinoless Double Beta Decay (0$\nu$DBD) and Dark Matter experiments, bolometers are very promising because of their favorable properties (excellent energy resolution, high detector efficiency, a wide choice of different materials used as absorber, ...). However, up to now, the actual interesting possibility to identify the interacting particle, and thus to greatly reduce the background, can be fulfilled only with a double read-out (i.e. the simultaneous and independent read out of heat and scintillation light or heat and ionization). This double read-out could greatly complicate the assembly of a huge, multi-detector array, such as CUORE and EURECA. The possibility to recognize the interacting particle through the shape of the thermal pulse is then clearly a very interesting opportunity. While detailed analyses of the signal time development in purely thermal detectors have not produced so far interesting results, similar analyses on macro-bolometers ($\sim$10-500 g) built with scintillating crystals showed that it is possible to distinguish between an electron or $\gamma$-ray and an $\alpha$ particle interaction (i.e. the main source of background for 0$\nu$DBD experiments based on the bolometric technique). Results on pulse shape analysis of a CaMoO$_4$ crystal operated as bolometer is reported as an example. An explanation of this behavior, based on the energy partition in the heat and scintillation channels, is also presented.Comment: Presented at the 14th International Workshop on Low Temperature Detectors, proceedings to be published in the Journal of Low Temperature Physic

Scintillating double beta decay bolometers

We present the results obtained in the development of scintillating Double Beta Decay bolometers. Several Mo and Cd based crystals were tested with the bolometric technique. The scintillation light was measured through a second independent bolometer. A 140 g CdWO_4 crystal was run in a 417 h live time measurement. Thanks to the scintillation light, the alpha background is easily discriminated resulting in zero counts above the 2615 keV gamma line of Thallium 208. These results, combined with an extremely easy light detector operation, represent the first tangible proof demonstrating the feasibility of this kind of technique.Comment: 15 pages, 8 figure

Study of scintillation in natural and synthetic quartz and methacrylate

Samples from different materials typically used as optical windows or light guides in scintillation detectors were studied in a very low background environment, at the Canfranc Underground Laboratory, searching for scintillation. A positive result can be confirmed for natural quartz: two distinct scintillation components have been identified, not being excited by an external gamma source. Although similar effect has not been observed neither for synthetic quartz nor for methacrylate, a fast light emission excited by intense gamma flux is evidenced for all the samples in our measurements. These results could affect the use of these materials in low energy applications of scintillation detectors requiring low radioactive background conditions, as they entail a source of background.Comment: Accepted for publication in Optical Material