Comparison of line-field confocal optical coherence tomography images with histological sections: validation of a new method for in vivo and non-invasive quantification of superficial dermis thickness

International audienc

In vivo characterisation of healthy human skin with a novel, non-invasive imaging technique : line-field confocal optical coherence tomography

International audienc

Skin lesion imaging with line-field confocal optical coherence tomography

International audienceAn original OCT technique called line-field confocal OCT (LC-OCT) is presented. Combining the principles of time-domain OCT and confocal microscopy with line illumination and detection, LC-OCT acquires multiple A-scans in parallel with dynamic focusing. With a quasi isotropic resolution of 1 µm, the LC-OCT images reveal a comprehensive structural mapping of skin, in vivo, at the cellular level down to a depth of 500 µm. LC-OCT images of various skin lesions, including carcinomas and melanomas, are found to strongly correlate with histopathological images. LC-OCT could significantly improve clinical diagnostic accuracy, while reducing the number of biopsies of benign lesions